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Biomedical subjects

M Leutenegger

Publications and source records attributed to M Leutenegger.

At least 73 records · Page 4Linked to original sources
PubMed1980

[The effects of probucol in man (author's transl)].

probucol is a new hypolipaemic agent which differs from similar drugs in current use by its chemical structurae and, probably, by its mode of action. Its predominantly cholesterol-lowering activity and its lack of serious side-effects make it a valuable product for the treatment of type IIa hypercholesterolaemia and of type II b mixed dyslipaemia. Whether or not it can be advantageously combined with other cholesterol-lowering agents in resistant hypercholesterolaemia remains to be determined. As with most drugs of this kind available at present, randomized prospective trials are required to demonstrate the efficacy of probucol in preventing atheroma and its safety in long-term usage.

Anticholesteremic Agents↗
PubMed1978

A micromethod for the evaluation of hemoglobin A1c: technique and preliminary results.

A microtechnique of column chromatography on a Biorex 70 resin monitored by permanent recording of the effluent o.d., permits to obtain the percent of Hb A1C in an hemolyzate within 1.5 hr (in the place of 6 hrs in the usual techniques). This evaluation was carried out in 18 normal subjects and 32 patients suffering from diabetes mellitus and was repeated several times in 10 patients. The average level in the normal subjects was 5.01% (3.2 to 6.1%), in the equilibrated patients with a glycemia under 2 g/l: 6.44% (5.74 to 7.14%) and in the poorly equilibrated patients: 8.9% (5.5 to 15.3%). Hemoglobin A1C appears as a valuable index of sugar metabolic equilibrium.

Blood Glucose↗
PubMed1978

[Hemoglobin A1c: a new factor in the supervision of diabetes (author's transl)].

Hemoglobin A1c is one of the minor components of normal human hemoglobin. It differs from Hb A by the presence of one molecule of glucose fixed to the N-terminal extremity of every beta chain. It is synthesized from Hb A by a very slow and only slightly reversible mechanism which continuously occurs during the 120 days of the red cell life. Hb A1c represents nearly 5% of total hemoglobin of the normal subject. In patients suffering of diabetes mellitus, its level seems to reflect closely the degree of equilibrium of the disease for 4 to 5 weeks which preceeded the evaluation.

Chemical Phenomena↗