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Biomedical subjects

M Lelong

Publications and source records attributed to M Lelong.

At least 19 recordsLinked to original sources
PubMed1992

[An outbreak of allergy to horses in children. A review of 56 recent cases].

Over the past 11 years, signs of allergy were observed in 56 children and adolescents in contact with horses. The cases consisted of 35 boys and 21 girls, 35 of them were under 10 years of age. The main clinical signs were ocular symptoms (36), asthma (30) and rhinopharyngitis (24). All the children had very positive cutaneous prick tests and specific IgE (class 3 and 4: 62%) and were polysensitized. In several children, the first manifestation occurred at the time of the first known contact with a horse or pony. No further contact was usually the only therapeutic solution. In disabled children, allergy to horses must be considered when clinical signs of allergy occur during therapeutic riding sessions.

Allergens↗
PubMed1990

[Does the allergic child become sensitized to small domestic mammals (guinea pig, hamster, rabbit?)].

Our own works show among allergic children a frequency of sensitization of 30% to cats and of 17% to dogs. But, the proportion of sensitizations to other small domestic mammals such as guinea pigs, hamsters of rabbits seems to be unknown. Among atopic children with a known contact with those pets we noted: for guinea pig: 29% positive cutaneous or RAST tests 21% clinical signs in presence of animals; for hamster respectively 28% and 6.5%; for rabbit respectively 18% and 12.3%. Guinea pigs seem to be more sensitizing animals, followed by rabbits, then by hamsters. As for cats and dogs, eviction is imperative when a sensitization is demonstrated.

Allergens↗
PubMed1989

[Is it necessary to test children having summer respiratory problems with cereal pollens?].

We tested 100 children with clinical signs that occurred in spring or summer. Prick tests were made with extracts of wild grass pollens (Dactylis, Phleum, Lolium) and with separate cereal pollens (Wheat, oats, Sweet-corn Barley and Rye). In 20 children whose test was negative for wild grass pollen, we saw no sensitization to cereals. In 80 children with grass pollenosis, Barley and Rye are the cereals that gave the most positive prick tests, whilst sweet corn is the cereal with most negative tests.

Allergens↗
PubMed1989

[Chronic rhinopathies of childhood (apropos of 265 cases)].

We observed among 265 children with a chronic rhinopathy: 187 allergic rhinopathies, associating sneezing, rhinorrhea and nasal eosinophilia, particularly caused by a sensitization for mites. 10 non allergic eosinophilic rhinopathies with identical clinical signs, and major nasal eosinophilia without any allergic factor. 68 non allergic non eosinophilic rhinopathies, where are preponderant nasal obstruction, olfaction troubles, ORL infections (otitis and sinusitis). Their etiology is probably various: psychic factors, ciliary dyskinesias, vasomotor phenomena...

Child↗
PubMed1988

[Comparative study of 3 positive controls for routine prick tests in children: 48/80, 1 mg histamine and 5 mg histamine].

We compared, among 153 children 2 to 14 years old, responses to some positive control solutions for prick tests made with a Stallerpoint. We obtained the following values: -6% - 48/80:4.46 +/- 1.88 mm -1 mg/ml Histamine:3.49 +/- 1.67 mm -5 mg/ml Histamine:5.13 +/- 1.78 mm. 1 mg/ml histamine gives too many null responses (12/153) to represent a valuable positive control. 5 mg/ml histamine, on the other hand, gives some very strong reactions which may induce an underestimation of responses to allergen tests. Compound 48/80 seems to remain the best positive control for prick test exploration of immediate allergy in children. An alternative might be an intermediate solution of histamine 2.5 mg/ml.

Adolescent↗
PubMed1986

[Long-term tolerance of specific hyposensitization with the aid of calcium phosphate-adsorbed mite extracts].

90 children receive a specific hyposensitization with calcium phosphate adjuvant purified Dermatophagoides pteronyssinus allergens. We note 44% very good results, 37% good results and 19% failures. We propose to begin with 1/1,000,000 concentration every other day until 1/10,000 concentration is obtained under antihistamine protection. Tolerance is satisfactory: moderate respiratory reaction are pointed out for 22 patients. No anaphylactic shock is encountered. For 80 children with more than three years recall, we totalled 3,700 injections for 340 watching years. Only eight patients are sight lost. 1/10,000 concentration is obtained in 72/80 followed up children.

Adolescent↗
PubMed1986

[Severe local reactions to mosquito bites. Apropos of 20 cases].

We relate 21 observations of children who present major local reactions, immediate and delayed after mosquito bites. An associated reagin mechanism is obvious in 8 patients: five positive cutaneous or RAST tests and three a basophil degranulation tests. They are mostly young children (14/21 an less 5 years old). After some difficult years, the evolution is finally favourable with a specific hyposensitization or under antihistaminic protection (ketotifen) during summer.

Animals↗
PubMed1986

[What problems does childhood toxocariasis currently pose? Apropos of 6 clinical cases].

About six observations of toxocariasis (visceral larva migrans syndrome). We relate six observations of toxocariasis among children. In one case, an ocular localization is probable. For other five patients, they are inapparent forms. The allergologist pediatrician may be consulted because of a major hypereosinophilia (greater than 10,000/mm3) and an elevation of total IgE (greater than 2,000 UI/ml). Allergic and current parasitologic assays are negative and diagnostic key is given by toxocara serology. We insist on interest and reliability of passive hemagglutination test with a purified antigen (titer greater than or equal to 1/320). Treatment now is preferably flubendazole (50 mg/kg/day for six days) eventually renewed.

Child, Preschool↗
PubMed1986

[Are there milder forms of the syndrome called hyper-IgE? Diagnostic problems. Apropos of 2 cases].

We present the observations of two boys eight and four years old whose the only clinical sign is a chronic otorrhea. We found many of usual features of the hyper IgE syndrome: raised total IgE (4000 to 8000 Ul/ml) and hypereosinophilia (1100 to 3800/mm3). We found a lowered proportion of CD8+ cells (suppressive or cytotoxic): 16 and 18% (normal values: 26 +/- 5%). The chemotaxis of polymorphonuclears is also lowered: 9.2 to 6.0 cells by microscopic field with FMLP presence (normal values 40 to 50). These two observations are compared with other literature cases where clinical picture is moderate, but biological signs very suggestive.

Child↗
PubMed1986

[Are the left-handed more often allergic?].

Are left handed more frequently allergic patients? With the same evaluation clinical criteria, we find a Non Right Handedness (left handed + mixed handedness) in 48/403 children (11.9%) at school in a town near our consultation place and in 152/625 (24.32%) children of the same age with a mites allergy (p less than 0.001). This non right handedness is among allergic patients more frequently observed for boys: 126/442 (28.50%) than for girls: 26/183 (14.20%). The mechanism is unknown but it has been hypothesized (Geschwind) that a male related factor might slow left hemisphere development and trouble immune system equilibration.

Child↗
PubMed1986

[Does immediate-type respiratory allergy occur regarding Stemphylium? Evaluation of 39 challenge tests].

Does immediate respiratory allergy with stemphylium exist? About 39 provocation tests. We present 39 children with positive cutaneous and/or RAST tests for stemphylium mold. Provocation tests individualize 19 patients (14 boys and 4 girls, 10 to 16 years old in 17/19) with a respiratory sensitivity: 6/10 by passive anterior rhinomanometry and 13/15 by bronchial tests. Clinical symptoms are asthma and spasmodic rhinitis (14/19), predominantly from june to august. We noted a mite allergy in 11 cases and a grass pollenosis in 13 children. Positive cutaneous and/or RAST tests are found for alternaria mold in 13/19 cases. We undertook a specific hyposensitization in 14 children with a three years experience in 10 cases. Tolerance is excellent. This provocation respiratory exploration shows the important role played by stemphylium mold in the etiology of recurring respiratory incidents in children.

Adolescent↗
PubMed1986

[Does mugwort pollenosis occur in children in the northern region?].

Is Mugwort pollenosis frequent among children in North of France? In North of France where no ragweed grows, mugwort (artemisia) is after grasses and plantago, the third pollenosis in children. Among 184 children with summer clinical signs, positive cutaneous tests with a mugwort extract are noted in 40 patients (21%). RAST are positive only in 23 on 34 children with positive cutaneous test. Among the 40 children only two are less 5 years old and 26 are more 10 years old. Respiratory provocation tests confirm in 13/19 cases a sensitization of upper or lower respiratory tract. No food allergy exists among those children.

Allergens↗
PubMed1986

[Role of rhinomanometry in childhood mite allergy apropos of 76 cases].

Place for Passive Anterior Rhinomanometry (PAR) in mite allergic children. PAR is a simple method to investigate chronic or recurrent rhinopathies in children. Among 59 investigations with a Dermatophagoides pteronyssinus extract, we found 27 positive responses, 3 doubtful results and 32 negative explorations. Nasal sensitization is usually important: the liminal dose is less than 250 mcg in 17/28 cases. Most children have no bronchial sensitivity. None of 14 children with negative cutaneous and RAST tests have nasal sensitivity. When cutaneous and RAST tests are both positive, 12/16 positive PAR are found. We note a nasal sensitivity in 3/5 cases with only cutaneous test positive and 12/26 cases with only RAST tests positive. For other mites a nasal sensitivity is found in 8 out of 14 explorations (Tyrophagus and Glyciphagus especially). Among all patients when cutaneous tests, RAST tests and history are doubtful for the real part played by mites in the child rhinopathy, nasal exploration allows more explicit diagnostic and therapy.

Adolescent↗
PubMed1986

[Can Acarus siro be considered an allergenic mite in children? Evaluation of 248 cases].

Among 248 allergic children we noted 44 children (21%) with strongly or moderately positive cutaneous tests (In seven out of these tested children respiratory provocation tests are very positive). They are urban children and their houses are not different from other allergic children. They are mostly boys (72%), more than 5 years old (91%), with an asthma (84%), a radiological sinusitis (45%), an hypereosinophilia (88%) and elevated total IgE (90%). 43/44 children also have positive cutaneous tests to Dermatophagoides pteronyssinus mite. Since respiratory sensitivity is exquisite, we undertook a specific hyposensitization for some patients with encouraging results.

Allergens↗
PubMed1986

[Comparison of specific IgE levels versus various milk proteins in 76 eczematous children].

Among 76 eczematous children, we realized a RAST test for whole milk and milk specific proteins: lactalbumin, lactoglobulin and casein. One of these RAST tests, at least, was positive for 27 children. Whole milk RAST test is the most frequently positive (77%) but some non specific reactions seem to interfere: only three children are clinically milk sensitive. Among specific proteins, lactalbumin is more frequently positive (59%) than lactoglobulin (51%) and casein (18%). Eczematous children with positive milk RAST tests, if compared to other eczematous children, have currently more mite allergies and positive egg RAST tests. They have a tendency (non significative) to be more frequently breast fed. The positivity of milk RAST tests seems to belong to a polysensitization and infrequently concerns a clinical allergy.

Antibody Specificity↗