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Biomedical subjects

M Leibowitch

Publications and source records attributed to M Leibowitch.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Principal muco-cutaneous aspects encountered in AIDS].

Due to the high frequency and variety of the mucous cutaneous signs, the dermatologists are facing many cases of AIDS. These signs are no specific but only the consequence of a cellular immunodeficiency; they can be encountered in other situations, more specifically after an immunosuppressive treatment. Therefore, the diagnosis can be evocated only from AIDS association of the mucous cutaneous manifestations with other clinical, epidemiological and biological signs. The Kaposi's sarcoma which is present in 35 of the observed AIDS is in fact the cutaneous aspect of a cellular immunodeficiency. In one hand, the clinical lesions have a quiet involvement without any associated disorder. At the opposite, cutaneous lesions have a fulminant dissemination associated to lymph nodes and/or visceral involvement and opportunistic infections: these cases have a very severe prognosis. Kaposi's sarcoma is not observed in the cases of post-transfusional AIDS. Chronical herpes occurs frequently during this syndrome, the lesions lasting above six weeks associated to anal or genital localizations. Chronical candidosis, clinically associated, has a mucous cutaneous localization with involvement of the oral cavity, progressively extending digestive system and respiratory tracts.

Acquired Immunodeficiency Syndrome↗
PubMed1982

[Kaposi's disease. 2 recent cases].

Known since 1872, the multifocal angiosarcoma called Kaposi's sarcoma takes different forms in different communities. It develops slowly among the mediterranean populations and Jewish Central Europe and most rapidly among Bantus, in Africa, and white homosexuals. Another aspect of the disease has been described in patients with transplanted kidney, where it seems to be associated with immunosuppressive treatments. The recent outbreak of Kaposi's sarcoma among homosexuals in New York and San Francisco raises new and difficult problems concerning its aetiology, as the outbreak cannot be entirely explained by pressure from sexually transmissible diseases. Having observed two new cases in France, the authors have attempted to re-evaluate the pathophysiological factors of the disease, the most constant of which seems to be a considerable degree of immunodepression, perhaps partly due to chronic infection.

Adult↗
PubMed1981

Clq deposits at the dermoepidermal junction: a marker discriminating for discoid and systemic lupus erythematosus.

Discoid lupus (DL) and systemic lupus erythematosus (SLE) patients have been comparatively evaluated for complement and immunoglobulin deposits at the dermoepidermal junction (DEJ) by immunofluorescence (IF). When IF was positive, Clq deposits were quasi-constantly found in SLE patients with or without skin lesions (90%), while Clq was found in only 29% of the DL patients. Of the 42 DL patients followed-up to at least 2 years, 4 have eventually evolved a systemic disease. In these 4, neither cryoglobulinemia nor significant titers of ANA had been found at the time of presentation. Only 1 of these 4 patients had initially circulating immune complexes (P.E.G) and a positive IF in a normal sunprotected area. Clq deposits at the DEJ were present in all these 4. Of the remaining 38 DL patients, none has progressed to SLE: 8 had had significant titers of ANA, 5 had had circulating immune complexes, and 3 others had had cryoglobulinemia. Thus Clq deposits in DL cases are associated with a relatively high incidence of eventual systemic disease. Taken together, these data suggest that Clq deposits in skin may be a marker for systemic lupus.

Adolescent↗