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Biomedical subjects

M Legrain

Publications and source records attributed to M Legrain.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

The yeast regulatory gene PHO4 encodes a helix-loop-helix motif.

Evidence is presented, based on sequence comparisons and secondary structure prediction, of the presence of a DNA-binding and dimerization helix-loop-helix motif in the yeast transcription activator PHO4. Interest in the existence of this first known motif in yeast is discussed.

Amino Acid Sequence↗
PubMedDate not supplied

[Prevention of infections in patients subjected to immunosuppressive drugs. Experience of a nephrologist].

Infective complications favoured by non-specific immuno-depression are common after renal transplantation. Often severe, they represent the main cause of mortality. Their prophylaxis is necessary at all stages of treatment. Before transplantation, the eradication of curable infective foci is essential, and certain patients must be excluded from the programme. The operation is simplified to a maximum. The conditioning is such that one does no longer expose to the risk of aplasia. These facts render useless the isolation of the patient on a sterile unit. In cases of poor tolerance of the transplant, with repeated rejection, the reduction and eventually the stopping of immunosuppression is necessary. This attitude implies often early return to treatment by repeated hemodialysis, but it preserves to a maximum the chances of a new transplantation.

Humans↗