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Biomedical subjects

M Ledvina

Publications and source records attributed to M Ledvina.

At least 37 records · Page 2Linked to original sources
PubMed1984

Formation of collagen-like fibrils from alpha-elastin.

Collagen-like structures were formed in solutions of alpha-elastin after heating to 57 degrees C and after treatment with absolute ethanol. A complex between acetyl-alpha-elastin and cetyltrimethylammonium bromide showed a similar structure. Thick fibrils (diameter approximately 100 nm), resembling those described by Volpin, et al.12 revealed transversal banding with periodicity of 39 to 62 nm. A possible mechanism for the formation of these fibers is suggested based on hydrophobic interactions.

Animals↗
PubMed1984

Fibrillar structure of alpha-elastin methylester complexes with glycoproteins and proteoglycans.

alpha-Elastin methylester forms with proteoglycan subunits and structural glycoproteins water-insoluble complexes which after staining with phosphotungstic acid (pH 7.0), reveal at large magnification bundles of slender smooth fibrils with a diameter from 4 to 5 nm. Similar fibrils can be observed after interaction of alpha-elastin methylester with chondroitin sulfate, but only if fixation with glutaraldehyde is used prior to staining. Phosphotungstic acid alters the organization of the complexes, in particular those formed with ligands of low molecular weight. The possible biological significance of the interactions studied is discussed.

Animals↗
PubMed1982

Superoxide dismutase levels in various radioresistant and radiosensitive tissues of irradiated rats.

The activity of superoxide dismutase (E.C. 1.15.1.1; SOD) was determined in male Wistar rats in order to evaluate the possible relationship between both the enzyme content in tissue and the resistance of this tissue to ionizing radiation (8,0 Gy, 60Co). Our results showed that some non-irradiated radioresistant organs (liver) had a high SOD activity and on the contrary, in some radiosensitive tissue (bone marrow) the SOD content was low. In spite of this observation it is not possible to generalize the statement that the radiosensitivity is directly conditioned by the SOD level without any exception. The SOD content in the spleen was higher than in the brain, but the spleen is remarkably radiosensitive, whereas the brain is not. The radiosensitivity of individual tissues probably reflected the changes of SOD activity after the irradiation.

Animals↗