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Biomedical subjects

M Lazzati

Publications and source records attributed to M Lazzati.

At least 37 records · Page 2Linked to original sources
PubMed1986

Disposition and metabolism of [14-14C] 4-demethoxydaunorubicin HCl (idarubicin) and [14-14C]daunorubicin HCl in the rat. A comparative study.

The disposition of [14-14C]4-demethoxydaunorubicin HCl ([14-14C]idarubicin HCl, [14C]IDR) and of [14-14C]daunorubicin HCl ([14C]DNR) was studied in male Sprague Dawley rats. [14C]IDR was administered either IV at 0.25 mg/kg body weight or PO at 1 mg/kg body weight, whereas [14C]DNR was dosed IV at 1 mg/kg body weight. The main elimination route for both compounds was the bile, fecal excretion representing 0.75-0.8 times the total dose at 72 h. Radioactivity due to [14C]IDR-derived species is released by the tissues at a slower rate than activity derived from [14C]DNR. After IV treatment comparable plasma levels are obtained, but tissue radioactivity is markedly lower with [14C]IDR, in keeping with the lower dosage. The ratio of plasma to tissue radioactivity is even higher in animals treated PO with [14C]IDR, because of the more extensive metabolism after this route of administration. The 13-dihydro derivatives of both [14C]IDR and [14C]DNR are the main metabolites in tissues, but in the case of the former, products of phase II reactions become more important at later times in liver and kidney and in excreta.

Administration, Oral↗
PubMed1984

Radioactive species in rat urines and tissues after [14C] AD 32 administration.

[14-14C]N-Trifluoroacetyldoxorubicin-14-valerate [( 14C]AD 32) was synthesized and administered IV to male rats at 9.09 mg/kg. Urinary radioactivity excreted in the 0-24 h interval was only 2.3% of the dose, N-trifluoroacetyldoxorubicin (AD 41), 13-dihydro-N-trifluoroacetyldoxorubicin (AD 92), and doxorubicin being the major urinary metabolites identified. Doxorubicin and AD 32 were the main radioactive species extracted from tissues at 24 h after treatment. The amount of doxorubicin present in the analysed tissue samples is in agreement with the relatively low toxicity of AD 32 compared with doxorubicin.

Animals↗
PubMed1984

Disposition of 14C-labelled 4'-epidoxorubicin and doxorubicin in the rat. A comparative study.

The disposition of 4'-epi-[14-14C]doxorubicinHCl (4'-epi-[14C]DXR) and [14-14C]doxorubicinHCl [( 14C]DXR) was studied in male Sprague-Dawley rats given 1 mg/kg body weight IV. Most of the radioactivity administered was recovered in the faeces (two-thirds of the dose within 6 days after administration), urine accounting for 15% of the 14C given during the same period. A significant amount of radioactivity was also found in expired air. Significantly higher levels of radioactivity were recorded in the plasma (40 min and 4 h) and liver (40 min) in [14C]DXR-treated animals, whereas in animals treated with 4'-epi-[14C]DXR a higher specific radioactivity was found in the kidneys (40 min and 4 h) and bone marrow (40 min). The total tissue residual radioactivity was greater (P less than 0.05) at 24 h for [14C]DXR (45.8%) than for 4'-epi-[14C]DXR (38.6%). The main radioactive species in urines were the unchanged drugs. Minor metabolites were represented by a polar fraction, 13-dihydroderivatives, and aglycones. Whereas aglycones represent an important fraction of extractable tissue radioactivity in liver samples of many of the treated animals, the unchanged drug was invariably the major radioactive component in spleen, lung, and kidney. Liver extraction studies showed the presence of significant amounts of bound radioactivity that could be recovered in soluble form only after incubation with deoxyribonuclease. The main radioactive species present in the bile were the unchanged drug and a polar fraction. The amount of the former was higher in [14C]DXR-treated than in 4'-epi-[14C]DXR-treated animals. On the other hand, partial glucuronidation of 4'-epi-[14C]DXR was deduced on the basis of results of enzymic hydrolysis of bile samples.

Animals↗
PubMedDate not supplied

[Prevalence of caries in first permanent molars].

The Authors study the prevalence of the caries in the first permanent molar teeth by using DMF6 and consider the possibility of using such parameter instead of DMFT in order to reduce the time of observation in future researches.

Child↗
PubMedDate not supplied

[Set-up: method review and implementation of a new protocol].

At present the set-up occupies an important role in orthodontic therapy and is a valid help both at diagnostic and therapeutic level. The intent of this work is to illustrate the set-up execution technique in its principal passages, giving some useful indications to realize the correct dental displacements. For this reason it's necessary to insert some contrivances, which allow to control dental displacements into the three space dimenions. In this way it's possible to obtain an exact and valid set-up which can be destinated to many employments in orthodontic therapy.

Humans↗
PubMedDate not supplied

[Post-orthodontic retention: experimentation with a new technic].

Retention is a problem which has acquired a growing importance in orthodontic therapy. Some studies infact have proved that relapse cases may happen frequently at the end of an orthodontic treatment. To prevent these relapses it's necessary a suitable period of retention. In this work we took into consideration the problem of lower incisors crowding and we proposed a method of retention with the application of a fixed maintainer from cuspid to cuspid. This maintainer is applicated with some contrivances to reduce the risk of maintainer removal.

Humans↗
PubMedDate not supplied

[Deciduous dentition and orthognathodontic prevention. 2].

One of the main factors in the prevention of malocclusion is the preservation of healthy primary dentition until the time of normal shedding. By this contribution the Authors describe the restorative procedures and the pulp and canal treatments to be applied in deciduous dentition as well as the clinical and therapeutic problems connected with the early loss and the abnormal persistence of deciduous teeth. These therapeutic measures, in addition to caries prevention, have a very important role in the promotion of the normal development of occlusion.

Child↗
PubMedDate not supplied

[Lingual appliances].

We have considered all the tongue brackets in trade, and we have analyzed their quality and their defects on the grounds of our clinic experience. Tongue brackets must have small gingival occlusion dimension and fine thickness, while its breath must be compatible with rotation control. Finally we can say that there are no really effective tongue brackets in trade.

Humans↗
PubMedDate not supplied

[Role of the lip-bumper in nonextraction orthodontic therapy: clinical-statistical study].

The purpose of this study is to investigate the morphologic and dimensional changes of lower arch that might occur in patients undergoing treatment with the lip-bumper. After a brief examination of the clinical applications of lip-bumper, we report the results of a research concerning 20 children in the mixed dentition period. The effect of this simple orthodontic appliance has been an expansion of the mandibular dental arch, with a real increase of arch length and transverse dimension. Therefore the lip-bumper can be used in non-extraction treatment of malocclusion, in order to obtain a space recovery in lower arch.

Child↗