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Biomedical subjects

M Laxenaire

Publications and source records attributed to M Laxenaire.

At least 19 recordsLinked to original sources
PubMed1995

[Violent paradoxal reactions secondary to the use of benzodiazepines].

A literature review allows to suggest that the central element of the paradoxical rage reactions due to benzodiazepine dose, would be a partial deterioration from consciousness, generating automatic behaviors, fixation amnesia and aggressiveness from desinhibition. The criteria to input an aggressive reaction to benzodiazepine dose must be strictly estimated. Two clinical examples illustrate this problem. The authors advance that the hypothesis of paradoxical rage reactions due to benzodiazepine dose, would result from a desinhibition phenomenon with serotoninergic mechanism.

Benzodiazepines↗
PubMed1994

[Corticotropin-releasing factor and anorexia nervosa: reactions of the hypothalamus-pituitary-adrenal axis to neurotropic stress].

The aim of this study is to obtain CRF (Corticotropin Releasing Factor) stimulation at a suprahypothalamic level with a psychological stressor and to evaluate its response in anorexia nervosa. CRF plays a major role in the mechanisms underlying the hypothalamo-pituitary-adrenal (HPA) system's response to stress. Animal studies clearly showed that CRF is involved both in the adaptation to a novel environment and the regulation of eating behaviour. CRF's staietogenic effect is mediated via the paraventricular nucleus. Three groups of age matched young women were studied: 8 patients meeting the DSM III-R criteria for anorexia nervosa, 8 underweight healthy volunteers and 10 normal weight volunteers. All subjects were submitted to an auditory stimulation test ("psychosocial stress test") consisting of an intellectual task in which maximal performance is impossible to achieve, the subjects being permanently disturbed by various meaningful noises. Subjects were asked to answer self-rating scales for anxiety and tension prior to and after the test. CRF reactivity was measured by salivary cortisol (RIA). After the test, anorexia nervosa patients exhibit a significantly higher salivary cortisol response compared to the normal weight volunteers. In most of cases, salivary cortisol response was not correlated with the psychological variables. The range of the response is very explosive in two anorectic patients. Our data are consistent with the hyperactivity of the corticotropic axis stress response in anorexia nervosa, but request further investigations to prove that.

Acoustic Stimulation↗
PubMed1990

Tolerability and pharmacokinetics of remoxipride after intramuscular administration.

A study was undertaken in seven schizophrenic patients to evaluate the tolerability and examine the pharmacokinetics of intramuscularly administered remoxipride after a single 200 mg dose and at steady state following repeated doses of 200 mg twice daily for one week. Comparisons of AUC, t1/2 and tmax using the Wilcoxon's signed rank test showed no significant difference between single dose and steady state indicating that the pharmacokinetics of intramuscular remoxipride were linear. The steady-state Cmax was found to be significantly larger than that after single dose and the increase was accounted for by the predicted accumulation factor, assuming linear kinetics. Although the inter-individual variability in plasma concentrations was large, the intra-individual variability was low as shown by the reproducibility of the single-dose and steady-state plasma curves. Remoxipride, administered intramuscularly, was well tolerated.

Adolescent↗
PubMed1989

[Is it possible to have a medical definition of family crisis?].

In our contemporary society, the traditional multi-generational family has to adapt and to organize itself around a smaller nucleus: "The nuclear family". Nowadays, the management of the crises which accompany significant Life Events (such as birth, marriage, retirement, death...) within this new family-system, is refrained by the lack of "relays" which were previously provided by the "enlarged family". In the absence of available relatives (that is, grandparents, cousins, etc...), it is now the Medical System which is addressed with the demand for help. Using worthy contributions of the systemic theories, the authors analyze the ambiguity of such a request and the paradox underlying it, namely, to take care of a "normal" family crisis. They emphasize two major dangers consisting of the "designation" of an identified patient and the risk of "phagocytosis" of the therapeutic system by the family system.

Adaptation, Psychological↗