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Biomedical subjects

M Laurent

Publications and source records attributed to M Laurent.

At least 253 records · Page 14Linked to original sources
PubMed1976

[Management following mammography revealing grouped microcalcifications without palpable tumor].

On the basis of a series of 60 cases, the authors report their experience of excision of grouped microcalcifications detected at mammography in the absence of any clinical sign. The breast zone in which the microcalcifications were located by the radiologist was removed surgically. Per-operatoire X-ray of the excised specimens using a mammography apparatus confirmed that the microcalcifications had been totally removed. In addition it was useful to locate aceuretaly the calcifications in view of a careful histological examination of the area. The technique led to the discovery of 27 carcinomas at a sub-clinical stage. A classification of the various types of microcalcification was established in relation to histology. It will be of assistance in suspecting malignancy on the basis of mammography findings in the majority of cases. Excision can then be reserved for cases of presumed malignancy or where a doubt exists. By detecting breast carcinomas at a sub-clinical stage, the method makes possible early and minimally mutilating treatment with the best chances of cure.

Biopsy↗
PubMed1975

Lens glycoproteins: biosynthesis in cultured epithelial cells of bovine lens.

1. Radioactivity from [3H]glucosamine is rapidly incorporated into cellular fractions of lens epithelial cells cultured in vitro. The incorporated isotope appears largely in glycoproteins of the cell surface that are exposed to trypsin and are released into a soluble form by proteolysis of intact cells. Glycoproteins are also secreted by cultured cells and can be recovered in the culture fluids. Sodium dodecysulphate-polyacrylamide gell electrophoresis shows that a range of glycoproteins with apparent molecular weights from approximately 14000 to 120000 are present. The relationships of these glycoproteins to collagen and the non-collagenous glycoproteins of lens basement membranes are discussed. 2. A plasma membrane fraction obtained from non-trypsinised lens epithelial cells contains one major glycoprotein of apparent molecular weight 120000. A major non-glycosylated polypeptide of molecular weight about 38000 detectable by Bloemendal et al. (1972) in plasma membranes of differentiated lens fibre cells was not prominent in lens epithelial cell membranes. 3. Examination of lens basement membranes extracted in various ways failed to reveal major glycoproteins of low molecular weight. Higher molecular weight glycoproteins, some of them related to collagen, were present.

Animals↗
PubMed1975

[Renal cystadenoma in children. Apropos of 5 cases].

The multilocular renal cystadenoma is a benign, rather uncommon tumor occurring in childhood (one case for 40 Wilms tumors). The clinical pathological study of five cases and the review of cases published in the literature show that this tumor, like all cystadenomata, is constituted by isolated cysts lined with cubic epithelium and inserted into each other. These cysts are included into mature mesenchymatous tissue. The renal cystadenoma appears as a large, regular, spheric mass, sharply demarcated from the pelvic cavities and renal parenchyma. Its volume is the main clinical sign. Occasionally, angiographic and echographic investigations may provide additional useful data. In some cases, the renal cystadenoma may be difficult to distinguish from a well differenciated cystic nephroblastoma. The differential features are emphasized and discussed. The renal cystadenoma must be regarded as a hamartoma developed from some metanephrogenic blastematous areas excluded from the normal embryogenetic process. The term of renal cystadenoma emphasizes the neoplastic nature and the macroscopic appearance of this tumor and must be preferred to designate this lesion.

Child, Preschool↗