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Biomedical subjects

M Lania

Publications and source records attributed to M Lania.

25 records · Page 2Linked to original sources
PubMedDate not supplied

Clinical evaluation of defibrotide in the treatment of arterial and venous vascular disease. A preliminary report.

Defibrotide is a new compound with antithrombotic and profibrinolytic activity. It increases the endogenous fibrinolytic activity by promoting the cellular activator of plasminogen from endothelial cells and by decreasing the concentration of its inhibitors. In this study we evaluated a total of 223 patients for a mean period of 43 days for the following vascular conditions: (a) superficial venous thrombosis; (b) prophylaxis against deep venous thrombosis; (c) peripheral vascular disease (ischaemic foot and intermittent claudication; (d) prophylaxis against TIAs in patients with carotid plaques determining embolization; (e) treatment of venous ulcerations determined by chronic venous incompetence; (f) patients with Raynaud's phenomenon and disease. The tolerability observed was good. No side effects were observed even in more prolonged treatments. The overall efficacy was good for all groups especially in comparison with other treatment already in use for these vascular conditions. In conclusion defibrotide is a particularly useful drug in these vascular diseases and can be used both for acute and chronic treatments.

Adult↗
PubMedDate not supplied

[Treatment of traumatic lesions of the hepatic artery].

Injuries to the porta hepatis, which are difficult to diagnose and require variable treatment, are rare. The mortality for the vascular injuries is directly correlated to the uncontrolled intraabdominal hemorrhage and the treatment requires primarily bleeding control. This paper reports a case of a laceration of the left hepatic artery in a young multi traumatized patient (due to a car accident). The hepatic artery injury was successfully managed by primary closure. Even if the treatment of the extra hepatic injuries of the hepatic artery is still controversial, standardized therapy approaches have been proposed. The repair of the hepatic artery is an occasional option. The simple ligation is the most common option, in fact the oxygen extraction from the portal venous blood increases if the artery is ligated and this is sufficient for a adequate hepatocellular function in a healthy liver. In reality, in literature, damages to the liver due to artery ligatures are described even in the case of a good portal flow. Repairing hepatic artery injuries should always be taken into consideration after having made necessary evaluations on the general conditions of the patient because it is preferable to attempt to bring the patient back to the "status quo ante" and therefore avoid possible complications.

Accidents, Traffic↗