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Biomedical subjects

M Landthaler

Publications and source records attributed to M Landthaler.

At least 253 records · Page 14Linked to original sources
PubMed1990

Congenital multiple plaquelike glomus tumors.

We encountered two patients with congenital multiple plaquelike glomus tumors. These lesions were present at birth and enlarged with body growth, attaining a diameter of up to 13 cm. The diagnosis was confirmed by histologic and electron-microscopic examination, which revealed the typical changes of glomus tumors. Immunocytochemistry findings demonstrated the tumor cells to be vimentin- and alpha-smooth muscle-actin-positive and desmin-negative. On ultrastructural examination, typical dense bodies and attachment plaques were easily found within the tumor cells. Glomus cells were coated by a thick basal lamina.

Child↗
PubMed1990

[Cutaneous amyloidoses].

Significant advances in basic research in biochemistry and immunology has tremendously increased our understanding of amyloidoses. The chemical structure of several amyloid proteins has been partly characterized. Specific antibodies may provide new methods for immunohistological diagnosis of amyloidoses. Cutaneous manifestations can affect the skin only or develop during the course of systemic amyloidoses. Although these conditions are so rare, dermatologists should be aware of the changing clinical manifestations of cutaneous amyloidoses if they wish to avoid diagnostic failures.

Amyloid↗
PubMed1990

[Unusual primary cutaneous localized amyloidosis].

The case of a 41-year-old female patient with an unusual type of primary localized cutaneous amyloidosis is reported. Clinical examination revealed lesions typical for macular cutaneous amyloidosis, while histology and histochemistry, in contrast, revealed the presence of nodular amyloidosis of the skin with deposition of lambda light chain amyloid.

Adult↗
PubMed1990

[Postoperative adjuvant therapy with interferon alfa-2B following laser surgery of condylomata acuminata].

Sexually transmitted diseases caused by human papilloma viruses, such as condylomata acuminata, are increasing in incidence and are often difficult to treat because of their tendency to recur. Many reports in the literature document the usefulness of interferons topically or systemically in these diseases. A randomized study was conducted to evaluate interferon Alfa-2b (Intron A) as adjuvant therapy following CO2 laser surgery of condylomata acuminata. A low-dose regimen was administered (two courses with 1 million I.U. s.c. daily for 6 days with a 2-week interval between the courses) and had hardly any side-effects. The recurrence rate in the therapy group was significantly reduced (42% vs 81%), so routine prophylaxis of recurrence with interferons in condylomata acuminata should be discussed.

Adolescent↗
PubMed1990

[Colloid milium].

The differential diagnosis and classification of colloid milium, a relatively rare disorder, may be difficult. In this paper, a case report of a 52-year-old male patient with characteristic clinical and histological signs of colloid milium is therefore presented. Recently gained insights into the aetiopathogenesis of colloid milium are discussed.

Colloids↗
PubMed1990

[Malignant melanoma of the penis].

In this paper the authors report on four of their own patients suffering from malignant melanoma of the penis, and the recent literature is reviewed. Growth of pigmented lesions and bleeding are the most important clinical symptoms. Malignant melanomas of the penis are often acrolentiginous melanomas; they occur predominantly in older patients and progress more rapidly than malignant melanomas of the common integument.

Follow-Up Studies↗
PubMed1990

[The dermatoscope. A simplification of epiluminescent microscopy of pigmented skin changes].

The poor prognosis of thick malignant melanomas emphasizes the importance of their early detection. Skin microscopy using a stereomicroscope has been shown to increase the accuracy of clinical diagnosis significantly in pigmented skin lesions. Owing to the development of the Heine Delta 10 dermatoscope, skin microscopy has become less difficult and more rapid. Therefore, this technique can now be applied routinely in daily office practice.

Basal Cell Carcinoma↗
PubMed1989

Excisional biopsy as the first therapeutic procedure versus primary wide excision of malignant melanoma.

The five-year disease-free rate (5-y-DFR) and five-year survival rate (5-y-SR) of 319 melanoma patients with a narrow excisional biopsy in local anesthesia as the first procedure followed by delayed wide excision, were compared with 5-y-DFR and 5-y-SR of 635 primary radically treated patients. Five-y-DFR and 5-y-SR did not differ in either group of patients. Furthermore, the time interval (less than or equal to 21 days versus greater than 21 days) between excisional biopsy and delayed wide excision had no influence on the outcome of the patients. Based on the results of the study and the literature, excisional biopsy of malignant melanoma followed by delayed wide excision is a safe procedure.

Adolescent↗
PubMed1989

[Late metastasis in malignant melanoma of the skin].

Among a total of 680 patients with advanced malignant melanoma, the interval between removal of the primary tumour and first manifestation of tumour progression was more than five years in 47 (6.9%: 28 women and 19 men, mean age 45 [range 27-70] years), more than 10 years in ten of them. In only eight was the thickness of the primary tumour more than 3 mm. A total of 29 patients died after the tumour progression. Survival time ranged from 1 to 120 months, mean 18 +/- 23 months. There was no correlation between manifestation-free interval and survival time after the first progression had occurred. It is concluded from these findings that patients with malignant melanoma should be followed up for at least ten years.

Adult↗
PubMed1989

Association of early malignant melanoma with nevocytic nevi.

The percentage of histologically associated malignant nevocytic nevi is essential for establishing concepts of histogenesis. The literature abounds with studies of this association. However, the results are conflicting and vary between 4% and 72% of malignant melanomas with associated nevocytic nevi with a maximum frequency between 20% and 30%. These different values could be partially explained by the fact that tumors in more advanced stages might have "overgrown" preexisting nevocytic cells. For this reason, only cases of early stage malignant melanoma (tumor thickness less than or equal to 1.5 mm; level of invasion less than or equal to III) were included in this study (n = 150). Thirty-three (22%) of 150 cases of malignant melanoma were associated with nevocytic nevi. In an additional 6.1% of the cases there was a possible but doubtful association. In 45.4% of the cases the nevus cells could be detected below the tumor, in 18.2% they could be seen at the laterally adjacent sides, and in 36.4% they were found at both sites. Fifty percent showed junctional activity from the nevocytic nevi located to the side of the melanoma. We conclude that the finding of approximately 27% of nevocytic nevi with junctional activity among the nevocytic nevi associated with malignant melanoma could be an indicator that at least some malignant melanomas develop within or next to a preexisting and still proliferating nevocytic nevus.

Humans↗
PubMed1989

[Treatment of stage I malignant melanoma. Open questions and recommendations].

The excision of malignant melanomas is accepted worldwide as a therapy of choice but there are controversies concerning resection margins, prophylactic lymph node dissection, isolated hyperthermic perfusion of extremities and adjuvant therapy in high-risk patients. The relevant literature is analyzed with regard to these aspects, and based on this analysis and our own experiences in more than 3,600 melanoma patients, recommendations for therapy of primary malignant melanomas and follow-up are given.

Combined Modality Therapy↗
PubMed1989

Nd:YAG laser therapy of an oral verrucous leukoplakia.

A 75-year-old female patient afflicted with an extensive verrucous oral leukoplakia is reported. With treatment by the Nd:YAG laser under local anesthesia on an outpatient basis, the disease could be kept under control for 4 years.

Aged↗
PubMed1989

[The number and distribution of nevus cell nevi in patients with malignant melanoma].

Total-body cutaneous examination of 211 patients with malignant melanoma (MM) and 157 controls showed that patients with MM had significantly more nevi. Among MM patients, men had more nevi on the trunk than women, and women had more nevi on the lower extremities than men. Men had an MM distribution that was similar to their nevus distribution. Women, however, had proportionately more MM on the legs and fewer MM on the neck. The "nevus density," defined as the number of nevi per unit surface area of skin, was higher in male MM patients. The nevus density was highest on the head and neck, and lower on the lower extremities and anterior trunk. Patients with nodular melanoma had more nevi than those with superficial spreading melanoma. MM patients with a family history of many nevi had more nevi than those without such a history. Patients with a family history of MM did not show an increased number of nevi, but they had larger numbers of suggestive nevi removed than those without a family history of MM. We believe that many of these observations are consistent with the view that MM is caused by a genetic predisposition to an overactive melanocytic system in combination with an external stimulant, such as UV radiation.

Adolescent↗
PubMed1989

[Spindle cell lipoma].

A 74-year-old patient presenting with a subcutaneous tumor on his right upper arm is reported. Clinical examination led to the suspicion of a lipoma, cyst, and subcutaneous metastasis. Microscopical and immunohistological investigations allowed diagnosis of the tumor as a spindle cell lipoma. The most important aspect of differential diagnosis of this benign tumor is the exclusion of liposarcoma.

Adipose Tissue↗