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Biomedical subjects

M Lambert

Publications and source records attributed to M Lambert.

At least 433 records · Page 24Linked to original sources
PubMedDate not supplied

Cognitive dysfunction at baseline predicts symptomatic 1-year outcome in first-episode schizophrenics.

The present study addresses the consequences of cognitive disturbances on symptomatic outcome. Fifty-three first-episode schizophrenics were reassessed (n = 32) 1 year after admission. Simple regression analyses revealed that several self-perceived cognitive deficits at baseline as measured with the Frankfurt Complaint Questionnaire significantly predicted increased Brief Psychiatric Rating Scale global scores at follow-up (p = 0.05 to p = 0.005). A stepwise regression analysis proved memory dysfunction to be the strongest predictor of symptomatic worsening (p = 0.005). It is suggested that the exploration and treatment of neuropsychological deficits in schizophrenia is of great clinical importance with regard to its impact on both functional and symptomatic outcome in schizophrenia.

Acute Disease↗
PubMedDate not supplied

Homozygous familial hypercholesterolemia among French Canadians in Québec Province.

Nineteen patients with homozygous familial hypercholesterolemia (FH) living at the time of the 1981 Canada census are the subject of this report. Their mean age at that time was 15, with a range of 1 to 26 years. All patients had extensive xanthomatosis but showed variable clinical manifestations of coronary heart disease (CHD); five (mean age, 21; range, 11 to 27 years) died from sudden death due to CHD. Plasma cholesterol levels varied more than twofold (557 to 1532 mg/dl). Variation in the concentrations of both plasma and low density lipoprotein cholesterol, as well as apolipoprotein B, were related neither to age at death from CHD nor to the clinical course of CHD. The mean high density lipoprotein cholesterol concentration (37 mg/dl) was lower than the mean value (49 mg/dl) in the control population (p less than 0.001). Both the clinical and biochemical features of this cohort are typical of homozygous FH. The prevalence of homozygotes among French Canadians in Québec was approximately 1:275,000, and the minimum estimated frequency of heterozygotes was 1:270. In northeastern Québec, the frequency of homozygotes was approximately 1:100,000, and the minimum estimated frequency of heterozygotes was 1:154. Only Afrikaaners in South Africa have correspondingly higher frequencies.

Adolescent↗
PubMedDate not supplied

Bilateral optic neuropathy associated with the crest variant of scleroderma.

We report a case of bilateral optic neuropathy associated with the CREST syndrome, a variant of scleroderma. Immunosuppressive therapy achieved significant improvement of the visual symptoms for two years. The pathophysiological mechanisms underlying this unique association remain unclear.

Adult↗
PubMedDate not supplied

Recurrent immuno-allergic hepatitis related to amoxicillin-clavulanic acid.

We report on a patient who presented, on 2 occasions at one-year interval after a treatment with the amoxicillin-clavulanic acid association, a clinical and biological picture in keeping with the diagnosis of immuno-allergic hepatocellular hepatitis. On liver biopsies, the most characteristic finding was portal and lobular eosinophilic infiltration without cholestasis and biliary ducts damage.

Amoxicillin-Potassium Clavulanate Combination↗
PubMedDate not supplied

Severe hypophosphatemia in a patient with anorexia nervosa during enteral refeeding.

Hypophosphatemia is a seldom but potentially fatal complication of the nutritional recovery or refeeding syndrome in patients with protein-calorie malnutrition or starvation. We report here the case of a 35-year-old anorexic patient who presented a severe but uncomplicated hypophosphatemia during enteral refeeding, despite phosphorus supplementation. Serum phosphorus monitoring is recommended in severely malnourished anorexic patients, particularly during the first week of refeeding, be it parenteral or enteral.

Adult↗
PubMedDate not supplied

Ministry forges a special bond between a parish and a hospital.

What happens when a parish and a hospital join forces to help meet the physical, social, and spiritual needs of patients? The patients benefit, the hospital benefits, and the parish benefits. A Twining Ministry has expanded patient care at Mercy Hospital in Urbana, Il, where people from St. Matthew's parish in neighboring Champaign volunteer at the hospital. The parish and the hospital teamed up for this effort when Sr. Myra Lambert, SSCM, working in the Pastoral care Department at Mercy, set out to develop closer ties with Catholic parishes in the community. Meanwhile, St. Matthew's was looking for ways parishioners could get involved in a ministry that extended beyond parish boundaries. The hospital chose the 25-bed rehabilitation unit as the focal point of the ministry. St. Matthew's recruited volunteers; Mercy trained them. About 50 volunteers are currently involved in the ongoing program. They assist by helping plan and carry out a variety of activities inside and outside the hospital. They visit patients and provide temporary homes for patients' families; they offer transportation, make phone calls, and do mailings for support groups. They also help with meals, write and read letters, take patients for walks, and transport them to other service areas in the hospital.

Catholicism↗
PubMedDate not supplied

Is the black thyroid really an innocuous pathological finding?

We report the case of a 24-year-old euthyroid woman in whom the discovery of a cold nodule in the left thyroid lobe led to a thyroidectomy. The surgical specimen was characterized by a diffuse black discoloration. Optical examination revealed brown granules within the apical portion of the follicular cells whereas ultrastructural studies showed intralysosomal lipofuscin-like deposits, all findings consistent with pathological descriptions reported in black thyroids associated with the intake of minocycline. Retrospectively, we were told that the patient had received this antibiotic for at least three years for the treatment of acne vulgaris. As experimental models have demonstrated potential antithyroid effects of the drug, it appears relevant to monitor thyroid tests in patients receiving long-term minocycline therapy.

Acne Vulgaris↗
PubMedDate not supplied

MR imaging findings in a patient with hepatic veno-occlusive disease.

We report the MRI findings in a 31-year-old woman with veno-occlusive disease. MRI demonstrated patent hepatic veins and patchy signal enhancement of the liver after gadolinium chelate injection. This enhancement was compatible with sinusoidal congestion. The diagnosis of veno-occlusive disease was confirmed by histological examination of liver biopsy. The diagnosis of veno-occlusive disease should be evoked when patchy liver enhancement suggestive of sinusoidal congestion is observed in the absence of hepatic vein thrombosis and congestive heart failure.

Adult↗
PubMedDate not supplied

Regression of Sweet's syndrome associated with Crohn's disease after anti-Tumour Necrosis Factor therapy.

The association of inflammatory bowel disease and acute febrile neutrophilic dermatitis (Sweet's syndrome) has infrequently been reported in the literature. We describe the case of a 41-year-old Caucasian woman with ileo- anal Crohn's disease who presented simultaneously an erythema nodosum and a Sweet's syndrome. A dramatic regression of the cutaneous lesions was observed after infliximab treatment, indicating that this therapy might be useful for both Crohn's disease and Sweet's syndrome.

Adult↗
PubMedDate not supplied

Coombs-positive autoimmune hemolytic anemia complicating ulcerative colitis. A case report.

We report the case of a 41-year-old woman with a 5-year history of left-sided ulcerative colitis easily controlled by sulfasalazine. She was admitted because of severe anemia, in the absence of any exacerbation of the colitis. A Coombs-positive (IgG type) hemolytic anemia was diagnosed and high-dose corticosteroid therapy was started, which proved to be unsuccessful. A splenectomy was then performed but the hemolytic anemia failed to subside. The patient was subsequently treated with a corticosteroid-azathioprine association with a sustained favourable effect on the anemia. The prevalence and pathophysiology of hemolytic anemia in ulcerative colitis is reviewed and a specific therapeutic approach is proposed.

Adult↗
PubMedDate not supplied

Erosive oesophagitis revealing acute zinc deficiency during parenteral nutrition. A case report.

We report a case of acute zinc deficiency which occurred during parenteral nutrition in a patient with anorexia nervosa and which was characterized by a painful erosive oesophagitis preceding the typical oro-cutaneous symptoms. We also discuss the interpretation of plasma and urine zinc levels, the predisposing role of total parenteral alimentation and the specific therapeutic implications.

Acute Disease↗