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Biomedical subjects

M Lambert

Publications and source records attributed to M Lambert.

At least 397 records · Page 22Linked to original sources
PubMed1980

Dependent proximal loop colostomy: does it defunction the distal colon?

The operation of dependent proximal loop colostomy is described. This colostomy avoids the complications of prolapse and paracolostomy hernia and is easy to close. It appears clinically to totally defunction the distal colon; his ability was studied by means of a radioactive tracer. Ten patients were given chromium-51 by mouth and it was found that none of this spilled over into the distal loop. It is concluded that dependent proximal loop colostomies effectively defunction the distal colon.

Colon↗
PubMed1980

[Characteristic rheograms of pathological bloods. Application to dynamic pharmacology (author's transl)].

The viscosity of normal and pathological blood samples is determined using a Couette viscometer (5.10-2s-1 less than or equal to shear rate less than to equal to 125 s-1). In different pathological cases, the rheograms show an abnormal behaviour. The viscosity curves exhibits a break between 0.1 and 1 s-1. This work shows the results obtained in the case of a patient suffering from Raynaud's disease. During therapy with lysine acetylsalycilate one observed the gradual shift of the breack to low shaer values, then, the return to a normal rheogram. In the same time, acroyanosis has completely disappeared, recovering normal nail growth.

Aged↗
PubMed1980

[Maximum rate of sedimentation of a suspension placed in a viscosimeter with coaxial cylinders. Application to a number of pathological blood samples (author's transl)].

Erythrocyte sedimentation of normal and pathological human bloods at varying controlled shear rates has been measured. Erythrocyte sedimentation rate (ESR) was found to reach a maximum at a characteristic shear rate gamma c [gamma c less than .1 s-1 for normal bloods; gamma c greater than .1 s-1 for pathological bloods]. Records of viscosity versus shear rate exhibit a break near gamma c. Examples show that ESR is well correlated with viscometric data.

Blood Sedimentation↗
PubMed1979

Genetic control of lysine permeases in Saccharomycopsis lipolytica.

In order to obtain strains of Saccharomycopsis lipolytica impaired in the active transport of L-lysine, mutants resistant to a mixture of L-canavanine, L-4-5-transdehydrolysine and L-S-amino ethylcysteine, taken either all three or two by two, were isolated. These compounds were shown previously to be competitive inhibitors of L-lysine uptake. The resistance patterns and excretion capacity of the mutants were established. All mutants behaved as monogenic. Recombination tests indicated that four genes at least were involved. All mutants were impaired in both high and low affinity L-lysine transport systems. Several hypotheses on the functions of these genes are put forward and discussed.

Ascomycota↗
PubMed1978

Characterization of (Mg,Ca)-ATPase activity in rat pancreatic plasma membranes.

1. Pancreatic plasma membranes containing a high adenylate cyclase activity and a low contamination by cytochrome c oxidase were isolated from the rat by sucrose density centrifugation. The preparation contained an (Mg,Ca)-ATPase of high activity with the following characteristics. 2. The ATPase activity was shown to have two apparent Km values for Mg-ATP (0.24 +/- 0.09 mM and 1.15 +/- 0.21 mM) and two apparent Km values for Ca-ATP (0.14 +/- 0.09 mM and 0.68 +/- 0.10 mM). Mg-GTP and Ca-GTP were also hydrolysed by the preparation. The phase transition temperature was 19.3 +/- 1.0 degrees C for the Mg-ATPase and 22.6 +/- 1.1 degrees C for the Ca-ATPase activities. 3. Three lines of evidence suggest that Mg-ATP and Ca-ATP were substrates for the same enzyme: Mg-dependent and Ca-dependent activities were not additive; the two activities showed the same pH optimum at 8.0; and the nonionic detergents Triton X-100, Triton X-305, Triton N-101, Lubrol P 12 A, and digitonin, produced a parallel solubilization of the two activities. 4. Enzyme activities were insensitive to potassium, sodium, ouabain, pancreozymin, carbamoyl-choline, secretin, concanavalin A, wheat germ agglutinin, and soybean lectin.

Animals↗
PubMed1978

Dissociation of cyclic GMP synthesis from cholinergic-stimulated secretion of protein from rat exocrine pancreas.

The phosphodiesterase inhibitors RO-201724/1 and 1-methyl-3-isobutylxanthine (MIX) stimulate a rapid increase in cyclic GMP content in rat pancreas; the latter agent also potentiates the stimulatory effect of carbachol on cyclic GMP synthesis. However, neither RO-201724/1 nor MIX alter basal secretion of 3H-labeled protein, nor do they affect the secretory response to carbachol used in either suboptimal or optimal concentrations. MIX as well does not alter the rate at which carbachol stimulates pancreatic enzyme release. The ability of carbachol to increase cyclic GMP synthesis is lost if extracellular calcium concentration is lowered to 0.05 mM; at this calcium concentration, however, the muscarinic agent still elicits a marked secretory effect. The dissociation between cyclic GMP synthesis and the secretory response suggests that the cyclic nucleotide does not play a major role in the stimulus--enzyme secretion coupling phenomenon of the exocrine pancreas.

Animals↗
PubMed1975

Histological-venographic correlates in portal hypertension.

Magnification hepatic wedge venography and manometry were evaluated in 40 patients with portal hypertension and in 6 normal individuals. Venography (alone or in combination with manometry) generally facilitated prediction of histology in cirrhosis, hepato-venular occlusive disease, periportal fibrosis, congenital hepatic fibrosis, and portal vein obstruction. The magnification wedge venograms demonstrated a number of histological features of cirrhosis that have not previously been described in vivo, including porto-hepatic vein shunts, micro- and macronodular regeneration, and obstructive changes which were more severe in hepatic than in portal veins.

Alcoholism↗