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Biomedical subjects

M Lacombe

Publications and source records attributed to M Lacombe.

At least 109 records · Page 6Linked to original sources
PubMed1979

[Study of macrophages infiltrating rat cardiac allografts. 1.--Description of the technique of heterotopic cardiac transplantation in the rat and morphological analysis of the cells infiltrating the graft (author's transl)].

The technique of heterotopic cardiac transplantation in the rat is described in detail. A simple, nontraumatic method of obtaining cellular prints from the heart is proposed for the study of cells infiltrating the allograft. Analysis of the morphological aspect of the cellular infiltrate present at the time of rejection in a series of allografts revealed a very high proportion of cells belonging to the monocyte-macrophage series, thus suggesting an important role for these cells in the rejection process.

Animals↗
PubMed1979

[Study of macrophages infiltrating rat cardiac allografts. II.--Cytoenzymatic analysis of cells infiltrating the grafts and of peritoneal macrophages in isograft and allograft recipients (author's transl)].

Cytoenzymatic analysis of cells infiltrating heart transplants in the rat confirms the high participation of monocytes and macrophages. However, when comparing iso and allografts, only slight differences are observed in the lysosomal enzyme specific colorations, whereas a striking difference in these colorations is found between heart infiltrates and peritoneal exsudates from these recipients. This could favour the hypothesis of a local macrophage activating process within the graft but seems more probably due to differences in cell maturation stages.

Acid Phosphatase↗
PubMed1978

Kidney-graft rejection: has the need for steroids to be re-evaluated?

In a group of azathioprine-treated patients whose renal allografts functioned immediately, 53 received prophylactic steroid treatment while 54 were given steroids only at the onset of the first renal failure. Three types of renal failure were identified, and their distribution in the patient groups was different, but the incidence of both reversible and irreversible renal failure episodes was identical in the two groups, suggesting that steroid treatment of early rejection episodes may not be necessary.

Azathioprine↗
PubMed1978

[Renal artery acute thrombosis following abdominal angiography. 3 cases (author's transl)].

Three cases of acute thrombosis of the renal artery following an abdominal angiography were operated on. In each case a tight stenosis of the renal artery was present. Two different clinical features were observed: when the thrombosis occurs in a solitary kidney, anuria follows immediately the angiography and this is highly suggestive of the diagnosis; when the contralateral kidney functions well, the thrombosis, probably, will not be recognized. Treatment should always be surgical. In two cases emergency surgery resulted in kidney salvage, whereas in the last the diagnosis was overlooked and delayed surgery could not avoid nephrectomy. Viability of the kidney may be ensured by the collateral circulation and this fact justifies surgery in all cases.

Adult↗
PubMed1978

[Retrograde repair of complex renal artery stenosis (author's transl)].

Among 60 cases of renal artery repair with venous or arterial autografts, 20 complex lesions involving the bifurcation and the branches of the artery were corrected by retrograde repair. This means that, after excision of the diseased artery, the graft is sutured to the distal branch(es) first, after which the proximal anastomosis is performed. This technique makes easier the distal sutures which are the most difficult, allowing complex repairs and often avoiding extra-corporeal surgery. The total clamping times were 65 to 110 minutes without any protection of the kidney against ischemia. No adverse effect upon renal function ensued these prolonged clamping times.

Aorta, Abdominal↗
PubMed1975

Arterial stenosis complicating renal allotransplantation in man: a study of 38 cases.

Of 306 renal transplantations, stenosis of the artery supplying the grafted kidney was found in 38 patients three months to two years after they had undergone renal transplantation. The diagnosis was made by arteriography done because of refractory hypertension with or without impaired renal function in 36 patients and as a routine investigation in two normotensive patients. The stenosis was corrected surgically in 14 patients, with resultant lasting relief of hypertension in ten patients and improvement of renal function in five out of six patients with impaired renal function. Different types of stenosis were recognized: stenosis of the recipient artery, stenosis of the suture line, stenosis of the donor renal artery (segmental or diffuse) and multiple forms. The most frequent site of stenosis was the donor artery. There seems to be no single cause of stenosis: atheroma of the recipient vessels, faulty suture technique, hemodynamic disturbances, trauma to donor or recipient arteries account for some cases, whereas in other cases the evidence points to an immune mechanism. This complication of renal transplantation may be more frequent than is thought at present; therefore, routine renal arteriography should be performed at repeated intervals in all transplanted patients.

Blood Pressure↗