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Biomedical subjects

M L Silverman

Publications and source records attributed to M L Silverman.

66 records · Page 4Linked to original sources
PubMed1984

Primary intrasellar germinoma in a woman presenting with secondary amenorrhea and hyperprolactinemia.

A 32-year-old woman with secondary amenorrhea was found to have an elevated level of serum prolactin, partial diabetes insipidus, and a subtle visual field defect. A primary intrasellar tumor was noted on the computed tomographic scan. Although the tumor had some characteristics of a prolactinoma, transsphenoidal exploration revealed a primary germinoma. The tissue diagnosis led to appropriate treatment with radiotherapy. The tumor regressed, and the patient had a spontaneous pregnancy. Had dopamine agonists been used initially, amelioration of the hyperprolactinemia and delay in the proper diagnosis and treatment would have occurred.

Adult↗
PubMed1983

Segmental pancreatic autotransplantation for chronic pancreatitis.

Three patients who underwent 95 percent removal of the pancreas for chronic pancreatitis with autotransplantation of the body and tail of the gland to the femoral area are described. The follow-up periods are 18, 6, and 2 months. Pain lessened in all patients and none required exogenous insulin. Patency of the graft was documented in all patients by angiography, technetium scan, and Doppler studies. Percutaneous selective venous assays of both external iliac veins showed a high insulin concentration in the transplanted side, both early and late in the postoperative period. In one patient the operative insulin levels obtained at the completion of autotransplantation proved to be highest in the external iliac vein on the transplanted side, lowest in the iliac vein on the nontransplanted side, and intermediate in the portal vein. Subsequent biopsies of the autografts showed fibrosis of the gland and atrophy of the acinar tissue with preservation of islet tissue. This technique appears to offer a means of preserving endocrine function in selected patients who require extensive resection for chronic pancreatitis.

Adult↗
PubMed1981

Mixed mucinous and papillary adenocarcinoma involving male urethra, probably originating in periurethral glands.

The case of a patient with primary adenocarcinoma involving the urethra is described. Morphologic evidence supporting an origin in the periurethral glands is presented. The urologist and pathologist must maintain a high index of suspicion in evaluating patients with urethral structure or urethrocutaneous fistulae because superficial transurethral biopsy may fail to obtain adequate depth to demonstrate malignancy.

Adenocarcinoma, Mucinous↗
PubMed1978

Splenic hamartoma.

This paper describes five cases of splenic hamartoma, a benign lesion, usually found incidentally in the spleen at autopsy. The current practice of laparotomy for staging of malignant lymphomas, especially Hodgkin's disease, has increased the numbers of surgically removed spleens. Because splenic hamartomas may be confused histologically with Hodgkin's disease involving the spleen, the authors have reviewed this entity, stressing the importance of recognizing and distinguishing it from a malignant process.

Adult↗
PubMedDate not supplied

Postirradiation hemangiosarcoma of the chest wall. Report of a case.

An unusual case of cutaneous hemangiosarcoma that developed on a chest wall irradiated after mastectomy for cancer is described. The patient, an elderly woman, had previously received high-dose radiation to the chest wall as well as systemic combination chemotherapy. Sarcoma developed 6 years after mastectomy and progressed rapidly. The time between radiation therapy and occurrence of cutaneous sarcoma was shorter than the median latent period reported for development of radiation-induced sarcoma. Thus, we cannot be certain that radiation was the true or sole etiologic factor. Whether the addition of systemic chemotherapy was a contributory agent is also speculative.

Aged↗