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Biomedical subjects

M L Picazo

Publications and source records attributed to M L Picazo.

51 records · Page 3Linked to original sources
PubMed1980

[Wilms' tumor: a series of 79 cases (author's transl)].

79 cases of Wilms' tumor with age at diagnosis between 0 and eight years, are reported. 76 of them are evaluable for therapeutic results. 54 (71%) are alive and disease-free, with a mean survival of 53 months. Group A (35 patients) received pre-surgical treatment with radiotherapy and the survival rate is 77%. Group B (32 patients) were not treated before surgery and the survival rate is 84%. Both groups received post-surgical treatment with radiotherapy and chemotherapy (vincristine and actinomycin D). Patients in group C, chronologically the oldest, did not receive chemotherapy and its survival rate was 20%. Prognostical significance of age, sex, site, clinical stage and histology are examined. Classical concepts on histological classifications are revised and present criteria are shown, along with its' therapeutic and prognostic implications.

Child, Preschool↗
PubMed1979

[Bone lymphangiomatosis (author's transl)].

A case of lymphangiomatosis of bone in a 12-years old boy is presented. First bone lessions were seen at 6 1/2 years of age and the case had a progressive course. The only associated lymphatic malformation was a submandibular lymphangioma. The lymphography performed at the patient was normal. Literature about this subject is revised and evolutive possibilities and therapy are described.

Bone Marrow↗
PubMedDate not supplied

[Progressive systemic sclerosis associated with anti-myeloperoxidase ANCA vasculitis with renal and cutaneous involvement].

Sclerodema renal crisis is the usual form of presentation of renal disease in systemic sclerosis. We report a woman who at age 63 was given a diagnosis of scleroderma with Raynaud's phenomenon and cutaneous, oesophageal and lung involvement but no evidence of renal disease and no treatment with D-penicillamine. Two years later she developed progressive renal failure, nephrotic range proteinuria, haematuria and the presence of serum MPO-ANCA; she was normotensive. Renal biopsy revealed extracapillary and necrotizing glomerulonephritis and skin biopsy showed leucocytoclastic vasculitis. This clinical picture was compatible with necrotizing vasculitis of the microscopic polyarterits type. After treatment with pulse steroids followed by oral steroids and monthly intravenous cyclophosphamide her renal function stabilised and the serum MPO-ANCA disappeared.

Aged↗
PubMedDate not supplied

[Idiopathic membranous nephropathy in an elderly patient with type 2 diabetes mellitus].

We report an 85 years-old patient with type 2 diabetes mellitus and both clinical and biochemical nephrotic syndrome. The renal biopsy showed membranous nephropathy at stage I-II. There was no evidence of malignancy. The patient was treated with steroids, and two months later the proteinuria had not improved. The objects under discussion are the factors that should lead to suspect the existence of glomerulonephritis, other than diabetic glomerulosclerosis, suggesting the need for kidney biopsy. We also focus on the prognostic and therapeutic relevance, as well as on the common pathogenic aspects.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[Multilocular renal cyst: clinico-pathological considerations apropos of a case and review of the literature].

A case of multilocular renal cyst (MRC) is reported in a hypertensive patient in whom the IVP had disclosed a left renal mass. The ultrasound and CT workup revealed a well-defined, solid renal mass that was angiographically hypovascular. Cytologic examination of the specimen obtained by fine needle aspiration biopsy yielded no conclusive data. A left radical nephrectomy was performed. The histologic diagnosis was that of multilocular renal cyst. At 42 months the patient remains hypertensive with no evidence of tumor recurrence. We discuss the diagnostic criteria of MRC and the difficulty in making the differential diagnosis from renal carcinoma, and describe the histologic features of MRC that permit us to distinguish this disease entity from other renal tumors or dysplastic disease with different biologic significance.

Carcinoma, Renal Cell↗