Search PubMed⌕ Search

Biomedical subjects

M L Moore

Publications and source records attributed to M L Moore.

At least 73 records · Page 4Linked to original sources
PubMed1987

Regional program for prevention of premature birth in northwestern North Carolina.

We present our experience with introducing and implementing a prematurity prevention program in a 20-county region in northwest North Carolina. The program is based on the risk assessment and educational model. In the first 25 months of results available, 17,370 births occurred in women enrolled in the project. During 1985, 42.5% of all births in the region occurred in the project. During the time span examined, a downward trend was seen for rates of low birth weight births in public and private patients and for very low birth weight births in private patients. During 1985, private births in the project were significantly less likely to be low birth weight or very low birth weight than private births to women not in the project. These results suggest that regional implementation of prematurity prevention programs is feasible and that such programs are particularly appropriate for private patients.

Costs and Cost Analysis↗
PubMed1986

Potent vasopressin antagonists lacking the proline residue at position 7.

As part of a program to design potent antidiuretic vasopressin antagonists and to define the minimum effective pharmacophore requirements for vasopressin (VP) antagonist activity, we studied the importance of the C-terminal tripeptide of a previously reported peptide antagonist of arginine-vasopressin (AVP,1). The proline residue at position 7 in AVP is proposed to impart a conformational constraint to the peptide backbone that is essential for V2-receptor agonist activity. Since the structure-activity relationships for VP agonists and antagonists are different, we investigated the effect of proline on antagonist activity, by synthesizing analogue 3 lacking this residue. This analogue was found to retain a high degree of antidiuretic antagonist activity. Since deletion of the Gly residue at position 9 of the antagonist did not adversely affect VP antagonist potency, several vasopressin antagonist analogues (4-7 and 9) that lacked both the Pro and Gly residues were also studied. These, too, were found to block vasopressin V2-receptor activity. Our results indicate that neither the proline nor glycine residues are essential for antagonism of the V2 receptor.

Animals↗
PubMed1986

Vasopressin antagonist analogs modified at position 7.

Vasopressin antagonist analogs having alanine or glycine at position 7 were essentially equipotent with analogs with proline, N-methylalanine or sarcosine at position 7. This demonstrates that the conformational constraint imposed by an N-alkyl residue at position 7 is not necessary for binding of antagonist to the receptor, the exact opposite of what is seen in agonists. This suggests that antagonists bind to the receptor in a manner which is very different from that of agonists.

Animals↗
PubMed1984

Synthesis and characterization of iodinated vasopressin antagonists which retain high affinity for the vasopressin receptor.

The mono- and di-iodinated analogs of lysine and arginine vasopressin have been prepared previously but not well characterized chemically. Their biological activities are greatly reduced with respect to LVP or AVP. In this paper we report a convenient synthesis of iodinated AVP agonists and antagonists, their purification by high performance liquid chromatography, and their characterization by fast atom bombardment mass spectrometry. In contrast to the results obtained with agonists, the mono-iodinated vasopressin antagonist retains virtually the full receptor activity of its non-iodinated parent. This should allow the preparation of labeled vasopressin antagonists of high specific activity for receptor characterization and isolation.

Arginine Vasopressin↗
PubMed1982

Preschoolers' knowledge of their classroom environment: evidence from small-scale and life-size spatial tasks.

Preschoolers (N = 20) and student teachers (N = 10) were asked to reconstruct the complete layout of their familiar classroom using a small-scale model as well as using life-size furniture in their actual classroom. Children were given the model task once within a testing room (standard model) and once within their normally arranged classroom (cued model). Subjects were also given an isolated-location task in which they were asked to show the location of individual pieces of furniture, 1 at a time. Adults performed virtually perfectly on all tasks. Children demonstrated more knowledge about their classroom when no scale reduction was necessary (i.e., performance was significantly better in the classroom than on the model) and when information about spatial arrangement was available (i.e., performance on the cued model surpassed performance on the standard model). Nevertheless, some children still performed inaccurately, even with these additional aids. Results from the isolated-location task demonstrated that, when possible children rely on relational information in determining locations. Implications for conclusions about children's spatial competence are discussed.

Child, Preschool↗
PubMed1981

Pyochelin: novel structure of an iron-chelating growth promoter for Pseudomonas aeruginosa.

Pyochelin, an endogenous growth promoter that solubilizes ferric iron, has been isolated from Pseudomonas aeruginosa, including clinical strains. The structure of pyochelin has been assigned as 2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid and is of a different type from those previously assigned to siderophores (siderochromes) from bacteria. The assignment rests on 1H and 13C NMR data, high-resolution (including field desorption) mass spectrometry, and spectroscopic properties of synthetic model compounds. Pyochelin is presumed to be biosynthesized from salicylic acid and two moles of cysteine.

Growth Substances↗
PubMed1980

ECG-gated emission computed tomography of the cardiac blood pool.

ECG-gated cross-sectional images of the cardiac blood pool were produced using a specially constructed emission computed tomographic scanner. A pair of large-field-of-view cameras were mounted in opposition in a gantry that rotates 360 degrees about the patient. The coordinates of each detected event, the output of a physiological synchronizer, and the position of the camera heads were input to a dedicated minicomputer which was used to produce the images. Display as a movie permitted evaluation of regional and global wall motion in cross section without the disadvantages of superimposed blood pools as obtained in nontomographic views.

Electrocardiography↗
PubMed1979

Radionuclide computed tomography of the body using routine radiopharmaceuticals. I. System characterization.

A whole-body computed tomography system for single-photon emitters was evaluated from the standpoint of spatial resolution, sensitivity, and thresholds for count densities with reference to standard doses of currently used radiopharmaceuticals in patients. In air and tissue equivalents, spatial resolution was relatively constant throughout the field of view and attentuation correction algorithms returned uniformity of response to within 10%. In a phantom of the human abdomen 1.5-cm spherical "cold" lesions and 1-cm "hot" lesions could be resolved. Aspects of the partial-volume effect were observed and investigated. To detect 1.5 cm-cold lesions in an abdominal phantom, five million events were required.

Computers↗