Search PubMed⌕ Search

Biomedical subjects

M L Monaghan

Publications and source records attributed to M L Monaghan.

10 recordsLinked to original sources
PubMed1990

Identification and characterization of monoclonal antibodies reactive with bovine, caprine and ovine T-lymphocyte determinants by flow microfluorimetry.

Comparative flow microfluorimetric (FMF) analysis was used to identify and characterize 27 monoclonal antibodies (MoAbs) reactive with bovine T-lymphocytes. Determinants present on all circulating T-lymphocytes were recognized by 11 MoAbs, 8 of which blocked E rosette formation. Determinants present on only the BoCD4+ T-lymphocyte subset were detected by 9 MoAbs, while determinants restricted to the BoCD8+ T-lymphocyte subset were recognized by 7 MoAbs. Competitive labeling experiments demonstrated that determinants recognized by subset-specific MoAbs were present on BoCD4 or BoCD8 molecules. Comparative studies revealed that some determinants, both pan-T specific and subset-specific, were conserved on homologous (orthologous) molecules expressed on leukocytes from other species of ruminants. Polymorphism was evident with several determinants.

Animals↗
PubMed1986

Ageing changes in the bovine kidney.

A study of macroscopically normal bovine kidneys from three age groups (neonatal calves, 2.5- to 3-year-old bullocks and cull cows), with no abnormalities on urine analysis, was carried out by light microscopy, immunofluorescence and electron microscopy. There was a slight increase in the proportion of involuted nephrons with increasing age but the proportion of nephrons affected was not greater than 10 per cent in any age group. In contrast to the findings of earlier workers, no evidence of diffuse proliferative glomerulonephritis was found in the material examined. It was concluded that the above techniques should be applied to the investigation of renal disease in cattle, as has already been done in man and small domestic animals.

Aging↗
PubMed1986

A morphometric study of the bovine renal glomerulus.

A morphometric study of 30 glomeruli from perfusion fixed kidneys of each of four cattle revealed that the mesangial area occupied 23.1 per cent of glomerular area in two neonatal calves and 15.3 per cent in two 18-month-old bulls. This is a greater proportion than has been described in most species and bears out the subjective impression that the mesangium is more extensive in this species.

Animals↗
PubMed1983

Abattoir survey of bovine kidney disease.

A survey of the prevalence and type of renal disease was carried out at a Dublin abattoir in 1979-80. Of 4166 cattle surveyed, 173 (4.2 per cent) had kidneys rejected for gross abnormalities. The rejection rate was 7.7, 1.7, 2.2 and 28 per cent for cows, bullocks, heifers and bulls, respectively. The most common reason for rejection was focal interstitial nephritis (60.1 per cent of rejected kidneys). Other lesions included cysts (26.0 per cent), pigmentation (6.4 per cent), pyelonephritis (3.5 per cent), amyloidosis (2.9 per cent), glomerulonephritis (0.6 per cent), renal atrophy (0.6 per cent) and agonal haemorrhage.

Abattoirs↗