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Biomedical subjects

M L Miller

Publications and source records attributed to M L Miller.

At least 181 records · Page 10Linked to original sources
PubMed1981

Differential response to kidney mitochondrial calcium-regulating mixed function oxidases to thyrotoxicosis.

Induction of hyperthyroidism in chicks by 6 consecutive daily injections of either L-thyroxine, 40 microgram/100 g of body weight, or 3,3',5'-triiodo-L-thyronine, 4 microgram/100 g of body weight, suppresses kidney mitochondrial 25-hydroxyvitamin D3-1 alpha-hydroxylase activity by 50% but is stimulates severalfold the 24-hydroxylation of the substrate in the same organelle. Plasma calcium concentrations of vitamin D3-deficient or normal birds, 1.68 and 3.47 mM, respectively, do not change significantly in response to the two thyroid hormones. However, plasma phosphorus concentration in the vitamin D3-deficient birds increases markedly from 1.47 to 2.70 mM. A slight increase was noted in the plasma phosphorus level of normal birds receiving the hormones. The present study suggests that alterations in the enzymatic metabolism of vitamin D3 in the kidney are responsible for the disturbances of mineral balance in hyperthyroidism.

25-Hydroxyvitamin D3 1-alpha-Hydroxylase↗
PubMed1981

[Changes in the content of riboflavin and its coenzyme in tissues during the aging of rats].

Decreased riboflavin concentrations were again found in different tissues from old rats (23 months of age) as compared to younger animals (11 months of age). This decrease was observed in the liver, heart and brain (-7 to -10%) and mainly in the kidneys (-60%). In the first three organs it is due to a decrease in flavin adenine dinucleotide (FAD), whereas most of the time the flavin mononucleotide and free riboflavin (FMN R) contents remained unchanged. In the kidneys, both FAD and FMN R are decreased, the latter more so than the former. This phenomenon could be explained by a modification in the enzymatic activities involved in the riboflavin FMN-FAD metabolic pathways and would result from a decrease of thyroid activity during aging. In the spleen the total riboflavin concentration is increased in old rats without changes in the relative ratios of FAD and FMN R. No particular effect was observed in lung and muscle tissue during aging.

Aging↗
PubMed1981

Evaluation of a teat dip of chlorhexidine digluconate (.5%) with glycerin (6%).

Efficacy of a teat dip containing .5% chlorhexidine digluconate and 6% glycerin was tested on 46 clinically normal cows, each with functional quarters. Twice daily immediately after milking, all teats were exposed to a suspension containing 5 X 10(7) colony forming units of Staphylococcus aureus. After each exposure to the infective broth, the left teats were dipped in teat dip while the right teats remained as untreated controls. The study continued until sufficient number of infections occurred to establish efficacy. Mastitis screening followed standard procedures as established by the National Mastitis Council and identified 24 infected teats in the control group and 6 in the treated group for 75% efficacy. The tested teat dip was effective in reducing the incidence of intramammary infections caused by Staphylococcus aureus under experimental exposure. No chapping or irritation occurred with use of the teat dip.

Administration, Topical↗
PubMed1980

Depression in an adolescent delinquent population.

One hundred and twenty adolescents aged 13, 14, and 15 were given a structured psychiatric interview within 48 hours of their admission to a correctional facility. The interview assessed demography, social and delinquent history, family history, and drug and alcohol use and related problems. The interview issued diagnoses based on the Research Diagnostic Criteria. The adolescents were followed up with self-rated and observer-rated instruments. Twenty-three percent of the population met criteria for a major affective disorder. Observer blind ratings significantly identified the depressed group at 15 days. Self-ratings of depression did not separate the two groups. No pattern of antisocial or "acting-out" behavior differentiated the depressed group, although the depressed group did relate more of their problems to drug and alcohol abuse. A depressed or alcoholic family member significantly predicted for depression. Some possible unique cognitive aspects of depression in younger adolescents are explored, and implications for further research with delinquents are discussed.

Adolescent↗
PubMed1979

Innervation of the periarteriolar lymphatic sheath of the spleen.

During the course of a neurohistochemical and two independent electron microscopic studies of the mouse spleen, unmyelinated adrenergic nerves containing numerous dense core and lucent vesicles and devoid of neurolemma were observed adjacent to reticular cells and lymphocytes in the white pulp. Some of these nerves formed an intimate relationship with these cells. Since adrenergic substances have been reported to modulate the cell cycle of lymphocytes in vitro, these findings are suggestive of a neural influence on the cell cycle of lymphocytes in vivo.

Adrenergic Fibers↗