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Biomedical subjects

M L Margolis

Publications and source records attributed to M L Margolis.

26 records · Page 2Linked to original sources
PubMed1985

Pulmonary tumor microembolism.

Pulmonary tumor microembolism is usually recognized as a slowly progressive syndrome of dyspnea and pulmonary hypertension in a patient with an established diagnosis of malignant disease. We have reported an extremely unusual case in which the pulmonary tumor microembolism syndrome occurred in a patient without prior history of malignancy. Further, no primary tumor could be found on postmortem examination. Clinicians should be aware that this potentially treatable entity may affect a wider spectrum of patients than has been previously recognized.

Dyspnea↗
PubMed1985

Anergy in tuberculosis.

Anergy in tuberculosis is of considerable clinical and immunological interest. Although negative skin reactions may be secondary to improper tuberculin testing or to certain diseases, drugs, vaccinations and constitutional factors known to affect cell-mediated immunity, often no underlying explanation is apparent. Unexplained negative reactions occur with a highly variable frequency in a wide variety of tuberculous infections. Anergy in tuberculosis is usually generalized, is often accompanied by other immunologic abnormalities, and frequently disappears as the disease is treated. Most anergic patients do not differ substantially from reactive patients in clinical features or prognosis. The mechanism of anergy in tuberculosis is unknown, but leading hypotheses suggest that immunologic compartmentalization, suppressor cells, or serum inhibitors (perhaps of mycobacterial origin) may be involved.

Humans↗
PubMed1984

Hepatic granulomatosis and sarcoidosis. Further observations.

The etiology of hepatic granulomatosis discovered in patients with normal chest roentgenograms is controversial. Among 18 such patients studied in recent years, sarcoidosis was identified as the cause in 15 by demonstration of granulomatous inflammation in extrahepatic tissues, employing a variety of biopsy methods. Serum angiotensin levels were raised in all 10 patients tested and gallium scans were helpful in four of six cases. Prolonged fever was the most common symptom, but three patients had severe right upper quadrant pain, a manifestation of hepatic sarcoidosis not previously described. Improvement on corticosteroids was observed in the 14 treated patients, but incomplete response led to use of cytotoxic drugs in three cases. Sarcoidosis presents with normal chest roentgenograms more often than is appreciated and appears to be a common cause of unexplained persistent hepatic granulomatosis. A firm diagnosis should be established since treatment is long and frustrating. The prognosis is good but treatment for years is required in most cases.

Adolescent↗