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M L Knapp

Publications and source records attributed to M L Knapp.

23 records · Page 2Linked to original sources
PubMed1980

Pancreatic oncofoetal antigen (POA): its frequency and localisation in humans.

Pancreatic oncofoetal antigen (POA) has been isolated by affinity chromatography and used to standardise an immunoassay. POA was detected in foetal serum and in 97% of sera from 75 patients with carcinoma of the pancreas. Raised levels were also found in 16% of sera from 43 patients with chronic pancreatitis and in 3 of 156 patients with related conditions. Using an immunoperoxidase method, POA was regularly found in the foetal pancreas and in adult carcinoma of the pancreas. Weak staining was found in the foetal pancreas and in adult carcinoma of the pancreas. Weak staining was found in one carcinoma of the colon. Antisera from two other groups (Gelder and Moossa; Arndt and Thiele) react with the same antigenic moiety as does our anti-POA.

Antibody Specificity↗
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Finishing big by starting small. Continuous improvement is the key to enhancing community health.

Although healthcare organizations increasingly seek involvement in community health improvement, they are often unprepared to do so because of their inexperience in disease and injury prevention. In recent years, however, continuous improvement (Cl) methodology has produced insights that are useful in such projects. An organization considering a community health improvement project should, from the start, test it through "Plan, Do, Study, Act" (PDSA) cycles. The project's leaders should begin by selecting an issue to work on. They must accurately define the community and involve its members in the project, because health improvement work is most effective when the people who care most strongly about a problem help solve it. Leaders should clearly define the project's aim, perhaps through analyzing hospital records and other databases. In forming a collaborative group to work on the project, leaders should begin with a "core team," perhaps adding other members later. This team should track data using three kinds of measurement--global, intermediate, and process--building data evaluation into its daily practices. The team would do well to get the guidance of someone familiar with Cl methodology. It should also use a process involving regular meetings, time lines, a means of communicating with experts outside the area, and a format that enables it to document progress and capture lessons learned.

Community Health Planning↗