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Biomedical subjects

M L Goldstein

Publications and source records attributed to M L Goldstein.

At least 19 recordsLinked to original sources
PubMed1994

A comparison of dentoalveolar and venous blood.

Dentoalveolar blood from extraction sites immediately after surgery and venous blood from 28 adult patients was compared for quantitative, qualitative, chemical, and cellular differences. The absence of stem cells, osteoblasts, and osteoclasts from dentoalveolar blood suggests a very low osteogenic potential, no more than that of venous blood. This finding contradicts information supplied by the manufacturer of a microporous, polymeric, composite graft material recommended for use with placement of implants in immediate extraction sites and as onlay grafts to treat ailing implants. The manufacturer's directions call for mixing the alloplast with bleeding marrow harvested from holes drilled in the mandibular symphysis or from a curetted dental socket immediately after a dental extraction in order to stimulate immature marrow cells to form osteoblasts.

Adult↗
PubMed1988

Coping with AIDS. An approach to training and education in a therapeutic community--the Samaritan Village Program.

The emerging demographics of AIDS related disease and disorders suggests a redistribution toward the population of intravenous drug users (IVDU) and the sexual partners of IVDU's. Risk reduction strategies employing education and disease prevention appear to have had significant success within the gay community as borne out by changing epidemiologic data. This paper focuses upon one such approach that has been used in a residential therapeutic environment. It offers a practical working model that might be applicable in a variety of settings. It should be emphasized that this is not a one-step presentation of AIDS information, but rather that it is an ongoing program of AIDS education.

Acquired Immunodeficiency Syndrome↗
PubMed1986

[Value of high-resolution computed tomography in evaluating cervical herniated disks].

Previous difficulties in the diagnosis of cervical disk hernia were related to lack of non-invasive imaging techniques, but the gap has now been filled by CT scan imaging. A total of 442 patients with pains in neck, shoulder or arm were referred for a CT scan to exclude a cervical disk hernia. Of the group studied, 2% were found to have a herniated disk, 16% a lateral hernia and 9% combined lateral hernia-narrow cervical canal due to concomitant arthrotic changes. Assessment of correlation between CT scan images and myelographic and surgical findings indicated that CT scan imaging is a very precise, non-invasive method for investigation of cervical disk hernia.

Adult↗
PubMed1981

Small-intestine involvement in Waldenstrom's macroglobulinemia. Case report and review of the literature.

A patient presented with a three-year history of diarrhea and was found to have a monoclonal gammopathy (IgM lambda) and a malabsorption syndrome with dilatation of the small bowel. Small-intestinal biopsy revealed a homogeneous eosinophilic granular material between the epithelial cells. On electron microscopy this material was shown to consist of an electron-opaque background mixed wit radiolucent lipid sheres. Immunofluorescent studies showed the accellular material to consist entirely of IgM-reactive material. The patient's course and a review of the literature is presented.

Biopsy↗
PubMed1981

Scanning electron microscopy of mucosal biopsies of the human upper gastrointestinal tract.

There have been comparatively few scanning electron microscopic studies of mucosal biopsies of the human upper gastrointestinal tract. This report deals with the results of scanning electron microscopy of 21 mucosal biopsies: 7 esophageal, 2 from the gastroesophageal junction, 3 gastric and 9 duodenal biopsies. Mucosal biopsies were obtained at the time of fiberoptic endoscopy and were placed immediately into 2.5% glutaraldehyde in phosphate buffer, pH 7.4. After post-fixation and removal of mucus, tissue was processed by means of the O-T-O method, Dehydrated, critical point dried with CO2 and examined at 20kV. Scanning electron microscopy (SEM) of mucosal biopsies of the esophagus shows a mosaic pattern. Cell borders are clearly demarcated and there are find microridges on the luminal surface. There are varying degrees of detachment and desquamation of the superficial cells. Acute esophagitis was observed in 2 of the biopsies. At the gastro-esophageal junction, the squamous epithelium of the esophagus abuts in a jagged manner upon the columnar epithelium of the stomach. The SEM appearance of the gastric mucosa is characterized by the presence of hillocks with central depressions formed by the gastric pits. Flattening of the hillocks and invagination into the gastric pits were seen in a biopsy of a fold at a Billroth I anastomosis. The villi of the duodenal mucosa form tongue-like of finger-like projections. The luminal surface of the absorptive cells has a dense covering of microvilli. The openings of goblet cells are studied on the mucosa as minute depressed foci. Varying degrees of an acute inflammatory reaction were present in 5 duodenal biopsies. It is concluded that SEM should prove to be of value as an aid in the diagnosis of mucosal biopsies of the human upper gastrointestinal tract.

Adult↗
PubMed1976

Acquired drive strength as a joint function of UCS intensity and number of CS-UCS pairings: the effect of masses and distributed CS-UCS pairings.

The empirical law relating acquired drive strength, as measured by the latency of a hurdle-jump response, to UCS intensity and number of CS-UCS pairings was investigated. The effect on acquired drive strength of varying the intervals between successive CS-UCS pairings was also investigated. Ss were 150 male albino rats, 125-160 days old. The apparatus was the classically conditioned fear apparatus. Acquired drive strength was found to be curvillinearly related to UCS intensity and number of CS-UCS pairings when a 10 minute intertrial interval was used. The relationships were monotonic and hegatively accelerated. The effect of UCS intensity on acquired drive strength varied with the length of the intertrial interval. The findings of diverging functions relating UCS intensity to test trials support Spence's notion of multiplicative relationship between habit strength (sHr) and drive (d) in the determination of performance in aversive conditioning.

Animals↗
PubMed1975

Stimulus compounding in classical fear conditioning.

The effect of stimulus compounding in classical conditioning was investigated by conditioning one group of rats to a compound CS consisting of a buzzer and light and then conditioning separate groups of rats to the individual elements of the compound CS. On hurdle-jump test trials, the group of Ss conditioned to the compound CS performed better than Ss conditioned to the elements of the compound. Strength of conditioning to each of the elements of the compound CS was about equal. There was some evidence of a summation effect resulting from conditioning to the compound CS. Strength of conditioning to the compound CS was somewhat greater than the sum of the response strengths conditioned to the elements of the compound CS.

Acoustic Stimulation↗