Patient history and drug reaction.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to M L DeBard.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
A six-year series encompassing 1,073 cases of cardiopulmonary resuscitation (CPR) at St. Elizabeth Medical Center (SEMC) was analyzed and compared with 13,266 hospital CPR cases in the literature. SEMC had a CPR success rate of 56% and a survival-to-discharge rate of 24%, compared with 39% and 17%, respectively, in the literature. Compared with the anticipated death rate had these patients not undergone CPR, a hospital mortality reduction of over 6% was achieved. Resuscitation was attempted in about 30% of all deaths and in 1% to 1.5% of all admissions. Four or more resuscitation attempts on a patient during a single admission were uniformly associated with fatal outcome. The average age of CPR patients and survivors was 60 years. Half the primary causes were cardiac; one-fourth were pulmonary. CPR success was unaffected by patient location, but most patients initially arrested in the emergency department, which had the best survival to discharge rate. Of CPR patients who were discharged alive, 75% survived for at least one year. Fifty percent were alive after three years, and 20%, after five.
The development of modern cardiopulmonary resuscitation (CPR) is an exciting and surprising history to modern health professionals who rarely are aware of how new CPR really is. Artificial respiration began in the 16th century with Vesalius's work on living animals; progressed with the rise and fall of mouth-to-mouth, manual, and positive pressure ventilation methods of the 18th and 19th centuries; and culminated in 1958 with demonstration of the superiority of the mouth-to-mouth technique. Cardiac massage began in 1874, with the open chest method gaining ascendancy until the 1960 demonstration of the equality and greater ease of closed chest cardiac massage. Electrical defibrillation may have begun in 1775, but was not proven successful in animals internally until 1899. The technique was applied to man internally in 1947 and externally in 1956. The simultaneous use of all these modern CPR methods dates back only 20 years.
Though drug fever from methyldopa is well known, to my knowledge fever and hypotension simulating septic shock have never been described in this country as a syndrome resulting from methyldopa therapy. Three such cases are presented here, all proved on rechallenge. They erroneously accounted for almost 6% of all cases of septic shock at St Elizabeth Medical Center in the last ten years.
Explore the source record for details and available documents.