A semiquantitative procedure for estimating serum antitrypsin levels.
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Blood↗
Biomedical subjects
M L Collins
Publications and source records attributed to M L Collins.
The metabolic activity of intact cell dispersates from normal and oxygen intoxicated rats. AMRL-TR-65- 173.
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Animals↗
Low-resolution gamma-ray measurements of uranium enrichment.
We have developed smaller, lighter hardware (MCA and shielded detectors) that has been successfully transferred to the commercial sector. We have developed software that has received limited testing, the next release should be sufficiently robust for wide release to the general public. We have had initial success with more sophisticated analysis methods. We are pursuing medium-resolution tors and response function fitting in the expectation that both will cause significant improvements in this measurement technique.
Gamma Rays↗
Low-resolution gamma-ray measurements of process hold-up.
This tool, consisting of software with a compact detector, an M3CA, and an Intermec datalogger: 1. acquires and manages several hundred spectra in an hour; 2. produces prompt and reliable quantitative analyses; 3. is self-powered, easily carried and operated by a single user; 4. accomodates varying degrees of user expertise; 5. corrects for the effects of equipment geometry; 6. corrects for the effects of equipment attenuation; 7. tolerates facility variables such as temperature fluctuations and equipment accessibility; 8. has been subjected to quality testing under field conditions; and 9. does not require extensive specialized training for the operators.
Calibration↗
Studies on the blood of a Co (a-b-) proposita and her family.
The serum of a pregnant woman whose red cells typed as Co(a-b-) contained an alloantibody that, at the time of the infants delivery, was hemolytic in vitro and had a titer of 32,000 by the antiglobulin test. This antibody, which reacted with cells of all Colton-phenotypes except the proposita's own cells, showed very weak reactions with other Co(a-b-) cells and therefore cannot be called anti-Co3. The red cells of the proposita may carry a very weak Co3 antigen. No other persons of the Co(a-b-) phenotype were found in her members, among three of the four generations tested, suggested that an inhibitor gene may be responsible for the unusual Colton phenotypes in this family. The proposita's infant required one exchange transfusion with red cells obtained from the proposita. Red cells from 40,000 donors reacted with the serum of the proposita.
Adult↗
Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs delivered in pH-sensitive liposomes.
An antisense oligodeoxynucleotide against the human immunodeficiency virus type 1 (HIV-1) Rev response element, a ribozyme complementary to the HIV-1 5'-LTR, and the reverse transcriptase inhibitors 9-(2-phosphonylmethoxyethyl) adenine (PMEA) and (R)-9-(2-phosphonylmethoxypropyl)-adenine (PMPA) inhibited virus replication in monocyte-derived macrophages more effectively when delivered in pH-sensitive liposomes compared to the free drugs.
Adenine↗