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Biomedical subjects

M L Clark

Publications and source records attributed to M L Clark.

At least 145 records · Page 8Linked to original sources
PubMed1975

Synthetic thyroid releasing hormone (TRH) administered orally to chronic schizophrenic patients.

Synthetic TRH and PL were administered orally for 3 weeks (300 mg./day), to long-term institutionalized chronic schizophrenic patients, within the framework of a double blind placebo controlled crossover study. Significant changes in physiological and laboratory parameters suggested increased thyroid activity, but significant favorable psychiatric and behavioral changes were not observed. This study does not support the idea that oral TRH could be useful treatment for long-term institutionalized chronic schizophrenic patients, who generally respond readily to major neuroleptic drugs.

Administration, Oral↗
PubMed1974

Amino acid and peptide absorption in patients with coeliac disease and dermatitis herpetiformis.

A double-lumen perfusion technique has been used to study amino acid and peptide absorption in eight normal control subjects, 13 patients with untreated adult coeliac disease, and 16 patients with dermatitis herpetiformis who had varying morphological abnormalities of the small bowel. All subjects were perfused with isotonic solutions containing 10 mM glycyl-L-alanine and 10 mM glycine + 10 mM L-alanine. Patients with adult coeliac disease had impaired absorption of glycine (p < 0.01) and L-alanine (p < 0.05) from the amino acid solution compared with the control subjects. Amino acid uptake from the dipeptide solution was not significantly impaired, although four individual patients had impaired uptake of both amino acids. In contrast to these findings, very few patients with dermatitis herpetiformis had impaired amino acid absorption from either solution. Sodium absorption was impaired from both solutions when the groups of patients with adult coeliac disease and dermatitis herpetiformis with subtotal villous atrophy and partial villous atrophy were studied, and there were patients in each group who secreted sodium and water. The results suggest that malabsorption of dietary protein is unlikely to occur in dermatitis herpetiformis but may occur and contribute to protein deficiency seen in some severe cases of adult coeliac disease. The impairment of sodium and water absorption provides evidence that there may be functional impairment of the jejunal mucosa in dermatitis herpetiformis as well as in adult coeliac disease.

Adult↗
PubMed1974

Functional differentiation of human jejunum and ileum: a comparison of the handling of glucose, peptides, and amino acids.

The characteristics of glucose, glycine, L-alanine, and glycyl-L-alanine absorption from the jejunum and ileum have been compared in normal human subjects. A perfusion technique has been used, and correct positioning of the perfusion tube has been confirmed by measuring the differential jejunal and ileal handling of bicarbonate. Glucose and glycine were absorbed faster from the jejunum than from the ileum of all subjects studied, and L-alanine was absorbed faster from the jejunum than from the ileum in five out of six subjects studied. In contrast, the dipeptide glycyl-L-alanine was absorbed at comparable rates from the jejunum and ileum. Higher concentrations of free amino acids were detected in the luminal contents aspirated during the ileal dipeptide perfusions.These results emphasize the importance of oligopeptide transport in the absorption of protein digestion products, especially in the human ileum, and the practical implications of these findings are discussed.

Adult↗