Biomedical subjects
M L Christ
Publications and source records attributed to M L Christ.
Intranuclear cytoplasmic inclusions (invaginations) in thyroid aspirations. Frequency and specificity.
In order to determine the frequency and specificity of intranuclear cytoplasmic inclusions (invaginations), described by some as an important criterion for the cytologic diagnosis of thyroid carcinoma, 258 consecutive thyroid aspirates were reviewed. Intranuclear cytoplasmic inclusions were present in 91% of the papillary adenocarcinomas but were not seen in any of the benign thyroid lesions or in any of the few nonpapillary adenocarcinomas in the study. It is concluded that the presence of intranuclear cytoplasmic inclusions in thyroid aspirates is probably specific to thyroid carcinoma but is not necessarily restricted to the papillary variant.
Cytologic changes associated with vaginal pessary use. With special reference to the presence of Actinomyces.
The cytopathology of Papanicolaou smears from 23 postmenopausal women with vaginal pessaries is described. The following alterations, when seen in the smear of an elderly postmenopausal woman, were found to be strongly suggestive of pessary use: cytologic atypia in the form of severe inflammatory changes in squamous cells, atypical metaplasia, and reparative changes with a background pattern of acute inflammation and prominent superficial maturation of the squamous cells. A notable additional finding in 13 of the 23 patients was the presence of filamentous organisms resembling Actinomyces and morphologically similar to organisms recently described and specifically identified as Actinomyces in patients with intrauterine devices.
Fine needle aspiration cytology of toxoplasmic lymphadenitis.
A retrospective study of four cases of toxoplasmic lymphadenitis diagnosed by fine needle aspiration and confirmed by serology or biopsy is reported. The cytopathologic features of this disease, not previously described in the American literature, were found to be highly characteristic and are described in this report. Toxoplasmic lymphadenitis is a fairly common cause of lymphadenopathy, and surgical biopsy is frequently performed because of a suspicion of lymphoma. Since the disease is generally self-limited, no treatment is necessary, and fine needle aspiration can spare the patient unnecessary hospitalization and surgery.