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Biomedical subjects

M L Brooks

Publications and source records attributed to M L Brooks.

51 records · Page 3Linked to original sources
PubMed1989

Parkinsonism secondary to bilateral striatal fungal abscesses.

A 24-year-old man with an 11-year history of i.v. drug use rapidly developed parkinsonism clinically indistinguishable from MPTP toxicity and Parkinson's disease. Although tests were negative for the human immunodeficiency virus, radiologic evaluation revealed bilateral striatal lesions. Stereotactic biopsy demonstrated septate hyphae consistent with either aspergillosis or mucormycosis. Gradual improvement followed systemic therapy with amphotericin B.

Adult↗
PubMed1988

Adenylate cyclase-stimulating, bone-resorbing and B TGF-like activities in canine apocrine cell adenocarcinoma of the anal sac.

Canine apocrine cell adenocarcinoma of the anal sac (APO-AS) is a spontaneously occurring tumor that causes humorally mediated hypercalcemia in 90% of cases. To further define the nature of the responsible mediator in APO-AS, we examined tumor extracts from five APO-AS and four control tumors for adenylate cyclase-stimulating activity (ACSA). All extracts from APO-AS contained potent ACSA, whereas the four control tumors did not. The ACSA extracted from one tumor demonstrated a dose response curve parallel to that of synthetic bovinePTH-(1-34) and was 80% inhibited by Nle8,18,Tyr34 bPTH-(3-34)amide at a concentration of 10(-5) M. Extracts from three APO-AS and three control tumors were also examined for in vitro bone-resorbing activity (BRA). All APO-AS contained significant BRA, stimulating resorption 1.47 to 2.13-fold over basal, whereas none of the control tumors stimulated resorption. Purification of one extract using C18 reverse-phase high pressure liquid chromatography (RP-HPLC) resulted in a single sharp peak of ACSA which was 400-fold purified compared with the initial extract. This pool also contained significant bone-resorbing activity, whereas none of the adjacent pools did. Purification of a second extract using sequential CN and C18 RP-HPLC followed by size exclusion HPLC resulted in material that was at least 10,000-fold purified, and showed co-purification of ACSA and B TGF-like activity.

Adenocarcinoma↗
PubMed1987

Biplane stereoscopic magnification cerebral angiography.

An angiographic system capable of simultaneous biplane stereoscopic magnification cerebral angiography was evaluated. Stereoscopic imaging improved the morphologic depiction of aneurysms and of arteriovenous malformations. In a series of 357 patients, procedure time was reduced because the initial biplane stereoscopic series was nearly always diagnostic, obviating the need for additional angiographic views.

Cerebral Angiography↗
PubMed1985

Coordination of services for outpatients under concurrent medical and psychiatric care.

The proportion of outpatients with concurrent medical and psychiatric problems is high and is expected to increase, but coordination of services has not been satisfactory. The medical and psychiatric records of 28 patients under regular psychiatric and medical care were abstracted, for a total of 323 visits, to ascertain issues related to assessment and coordination of care. Results indicate that psychiatric therapists and primary-care providers do not perform satisfactorily in assessing medical and psychiatric problems, respectively, and in initiating coordination of their patients' health care. The implications of these findings for the training, education, and supervision of staff are discussed.

Community Mental Health Services↗
PubMedDate not supplied

MRI of pulsatile CSF motion within arachnoid cysts.

Flow void due to pulsatile motion of cerebrospinal fluid (CSF) has recently been demonstrated by a variety of magnetic resonance techniques with sensitivity to slow flow. It has been suggested that within fluid collections not communicating with the physiologic CSF space, there is less signal loss than with the physiologic CSF spaces. Utilizing the SSFP MR technique, which is sensitive to flow as slow as 1 mm/sec, we evaluated three patients with isolated arachnoid cysts. Irregular signal loss consistent with fluid motion was noted within all of the cysts, as well as within the physiologic CSF spaces. Definitive anatomic evaluation of these lesions, though, required ventriculography, an invasive technique.

Arachnoid↗
PubMedDate not supplied

Subdural mass lesion secondary to sarcoid granuloma MR and CT findings and differential diagnosis.

A patient with surgical and neuropathologically confirmed subdural sarcoid granuloma was evaluated using angiography, contrast-enhanced CT and MR. MR images were obtained on a superconducting magnet with T1, intermediate and multi-echo T2 weighted sequences. Review of the 2 prior cases of subdural sarcoid granuloma from the literature evaluated with MR confirm the variable nature of signal intensities of the lesion. MR was most useful in anatomically evaluating the lesion and planning neurosurgical intervention but both CT and MR alone, in this case, did not definitely obviate the other differential diagnosis including meningioma en-plaque, lymphoma, or metastasis.

Adult↗
PubMedDate not supplied

Osteogenesis imperfecta associated with basilar impression and cerebral atrophy: a case report.

Osteogenesis imperfecta is a disease of bone formation subdivided into two types, congenita and tarda. It is associated with bony fragility, blue sclerae and abnormality of tooth dentin. Rarely the tarda form is associated with basilar invagination or infolding of the foramen magnum and upper cervical segments into the posterior fossa. This results in hydrocephalus and a spectrum of neurologic dysfunction known as the foramen magnum compression syndrome. Many radiologic methods have been used to evaluate basilar invagination including plain film and CT. We describe a patient with osteogenesis imperfecta tarda examined with CT, with a unique finding of diffuse cerebral atrophy associated with basilar invagination.

Adult↗
PubMedDate not supplied

Parosteal lipoma of the finger: preoperative evaluation with computed tomography.

Lipomas are very common benign soft tissue neoplasms arising from fatty tissue and may occur anywhere in the body. They are usually slow growing, painless masses often noted in the extremities of adult women. Occurrence in the hands and feet is unusual and those found in the digits are extremely rare. We describe a case of a lipoma presenting as a soft tissue mass of the index finger and show how computed tomography was extremely helpful in preoperative assessment by accurately defining the size of the lesion, the degree of bone involvement, and even giving indication of its underlying pathology.

Fingers↗
PubMedDate not supplied

Computed tomography of odontogenic keratocysts.

Epithelium-lined cysts of the jaw can be either odontogenic or non-odontogenic. Cysts that exhibit keratinization of their epithelial lining are called odontogenic keratocysts. They compose approximately 8% of all odontogenic cysts. There is a frequent association with unerrupted teeth, and a high incidence of occurrence of keratocysts in the multiple basal cell nevus syndrome. The significance of odontogenic keratocysts is their high potential for recurrence after their removal. There is no specific radiographic feature, however, that distinguishes them from non-keratinized odontogenic cysts. High resolution computed tomography (CT) studies can exquisitely determine the extent of these lesions and pinpoint areas of cortical breakthrough as well as involvement of the teeth. This information is invaluable in surgical planning for excision of these lesions.

Adult↗
PubMedDate not supplied

Intracanalicular arachnoid cyst mimicking acoustic neuroma: CT and MRI.

A patient with a surgically proven intracanalicular arachnoid cyst was studied using computed tomography, magnetic resonance imaging, and air CT cisternography. The lesion had a similar radiographic appearance to acoustic neuroma and therefore, although rare, must be considered in the differential diagnosis of intracanalicular mass lesions. We report a case in which examination was performed, in evaluating the lesion, utilizing high-resolution air CT cisternography and magnetic resonance imaging (MRI).

Adult↗
PubMedDate not supplied

CT guided lateral C1-C2 puncture.

A technique for CT guided intrathecal contrast material administration via lateral C1-C2 puncture is described as an efficient strategy for evaluation of patients with recent cervical spine injury and quadriplegia.

Humans↗
PubMedDate not supplied

Magnetic resonance imaging in localization of EEG depth electrodes for seizure monitoring.

Preoperative evaluation of patients with medically refractory complex partial seizures requires intensive EEG monitoring. Part of this process may include insertion of depth electrodes into temporal lobe structures. Although many imaging methods have been used for stereotactic placement of the electrodes, only computed tomography (CT) has been used to verify position after implantation. We studied 30 patients in whom magnetic resonance imaging (MRI) was used to visualize the position of stainless-steel electrodes stereotactically implanted in the temporal lobes. The procedure is noninvasive, does not utilize radiation, and has the additional advantages of multiplanar capability, increased soft tissue contrast, and lack of bony artifacts commonly associated with CT.

Electrodes, Implanted↗
PubMedDate not supplied

Magnetic resonance imaging of calcaneal aneurysmal bone cyst.

A 7-year-old black male presented with a lytic, expansile lesion of the calcaneus. This lesion was studied with conventional x-rays as well as MRI. The MR examination demonstrated a multiloculated lesion with material of a high- and low-signal intensity appreciated within each loculation. Pathologic review of the lesion demonstrated an aneurysmal bone cyst.

Bone Cysts↗