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Biomedical subjects

M L Bernstein

Publications and source records attributed to M L Bernstein.

At least 73 records · Page 4Linked to original sources
PubMed1983

The differentiation of malignant lymphoma from anaplastic seminoma in a patient presenting with testicular and jaw swelling.

The histologic differentiation of anaplastic seminoma from lymphoma is often difficult. In the case presented, a malignant lymphoma showing prominent testicular and jaw involvement was initially interpreted as seminoma. The histologic and ultrastructural criteria for differentiation, as well as a comparison of the clinical and epidemiologic characteristics of these tumors, are discussed. A reassessment of previously reported cases of seminoma metastatic to the jaws/antrum, made relative to these data, suggests that in most cases the tumors may actually be lymphomas.

Diagnosis, Differential↗
PubMed1983

The application of photography in forensic dentistry.

Certainly, not all of these photographs and procedures are necessary for documentation. In the past, the dental charting and word of the forensic dentist on identification have been readily accepted and rarely challenged in court. However, in an era when technology has made quality photography accessible to all dentists, these techniques permit improvement of a procedure. Adding a photographic record to a written postmortem dental chart promotes accuracy and reproducibility of detail and is desirable and logical for a technique whose value is predicated upon its scientific nature.

Bites, Human↗
PubMed1983

External fixation as a secondary procedure.

Twenty-two patients were treated by external skeletal fixation as a secondary procedure after failure of primary management with other modes of treatment. Fourteen of these cases were infected at presentation. The average duration from the time of injury to the application of external fixation was 17 months. Ninety-five per cent of fractures united with this treatment, and there have been no recurrent infections, with a minimum follow-up evaluation of one year. Pin tract problems were frequent and consisted of drainage, with or without pin loosening. All patients allowed unrestricted weight-bearing experienced some form of pin problem, whereas only 12% of patients restricted to touch-down weight-bearing with crutches developed pin tract problems; none has had residual pin tract infections. External fixation is an effective secondary measure for injuries that have failed to unite by primary treatment. Use of external fixation requires close supervision of postoperative treatment and, especially, close attention to pin insertion and management.

Adult↗
PubMed1982

Noncardiogenic pulmonary edema following injection of methotrexate into the cerebrospinal fluid.

The most common pulmonary disorder induced by methotrexate is a gradually developing interstitial pneumonitis. The associated clinical manifestations include slowly progressive dyspnea and nonproductive cough, with extensive radiographic changes. One case has been reported following intrathecal methotrexate administration; the remainder occurred after either intravenous or oral therapy. We report two cases of rapidly developing respiratory distress following the administration of methotrexate into the cerebrospinal fluid. The clinical courses, radiologic findings, and, in one patient, the pathologic nature, are consistent with noncardiogenic pulmonary edema.

Abdominal Neoplasms↗
PubMed1982

Reduced T lymphoid colony growth in patients with progressive systemic sclerosis and rheumatoid arthritis.

T cell colony growth in semisolid medium, a sensitive indicator of disease-associated lymphoycte defects, was found to be depressed in patients with PSS and RA. In both disorders, more pronounced abnormalities were observed after incubation with suboptimal concentrations of the polyclonal mitogen PHA. Depletion of monocytes by adherence to plastic surfaces of addition of the prostaglandin synthetase inhibitor indomethacin did not correct the growth abnormality observed in PSS. Reduced colony-forming activity could not be attributed to serum inhibitory factors. The cellular abnormalities detected in patients with these connective tissue diseases were less pronounced than those found in SLE patients.

Adult↗
PubMed1980

Depressed T cell colony growth in systemic lupus erythematosus.

Phytohemagglutinin-stimulated peripheral blood T lymphocytes, plated in agar, are capable of forming discrete lymphoid colonies. In 35 normal subjects, the average number of colonies was 6,020 +/- 351 (SEM). By contrast, in 39 patients with systemic lupus erythematosus (SLE), the mean colony number was 2,774 +/- 384, a value significantly less than controls (P less than 0.001). Normal responses were measured in 5 patients with progressive systemic sclerosis and in 7 of 8 patients with rheumatoid arthritis. Colony growth in SLE showed a strong correlation with disease activity but did not correlate with responses of blood lymphocytes to phytohemagglutinin in suspension cultures, the number of circulating T cells, or serologic abnormalities.

Adult↗
PubMed1980

Histiocytosis X: a clinical presentation.

A 56-year-old male complained of chronic oral ulcers. Initial workup revealed diffuse alveolar bone destruction and other systemic disturbances including diabetes insipidus. Biopsy suggested histiocytosis X and further tests verified the diagnosis. A clinical differential diagnosis is developed, follow-up is presented and the entities comprising histiocytosis X are discussed.

Carcinoma, Squamous Cell↗
PubMed1979

The induction of hyperkeratotic white lesions in hamster cheek pouches with mouthwash.

Listerine mouthwash applied to the left cheek pouch mucosa of thirty-seven hamsters 45 minutes daily for 41 days caused diffuse, corrugated white lesions showing hyperkeratosis in 100 percent of the animals. The right (control) side showed essentially no changes in response to saline solution applied similarly. The significance of these findings is discussed.

Animals↗
PubMed1978

Oral lesions in Crohn's disease: report of two cases and update of the literature.

A review of twenty-two previously reported cases and two new cases of oral lesions of Crohn's disease shows that there is a predilection for occurrence in certain anatomic sites and that the appearance of lesions is dependent on location. The most frequently affected areas and their respective appearances are the buccal mucosa, showing a cobblestone pattern; the vestibule, demonstrating linear, hyperplastic folds and ulcers; and the lips, appearing diffusely swollen and indurated. Less frequent are lesions of the gingiva and alveolar mucosa, which reveal a granular, erythematous swelling, and the palate, represented by multiple ulcers of the aphthous type. The significance of the clinical lesions and their microscopic features id discussed, as is a differential diagnosis in similar-appearing lesions.

Adolescent↗
PubMed1978

Oral mucosal white lesions associated with excessive use of Listerine mouthwash. Report of two cases.

Two patients were observed to have asymptomatic, diffuse, filmy white lesions involving large portions of the oral mucosa. Both patients admitted to the topical use of Listerine mouthwash in excess of recommended doses. Other considerations in the differential diagnosis were eliminated by history. The lesions showed complete regression in 2 weeks following discontinuance of the lavage.

Adult↗
PubMed1978

Biopsy technique: the pathological considerations.

As the dental profession moves toward additional emphasis in detection of disease and sophistication in diagnosis, biopsy is being used with increasing frequency as a diagnostic tool. This article states and elucidates simple ground rules that govern the rationale of surgical sampling of pathologic tissue. The three most common deficiencies that hamper interpretation (tissue artifact, inadequate clinical information, and inappropriate tissue sampling) are discussed, and the biopsy approach to various types of clinical lesions is reviewed.

Biopsy↗
PubMed1978

Oral exfoliative cytology.

Oral exfoliative cytology can be a powerful tool for early detection of malignant and premalignant lesions as well as for some viral and fungal infections, if the limitations of the method are thoroughly understood and appreciated by the dental clinician. The rationale for oral cytology is developed and documented, and interpretations of the results are explained. Advantages and disadvantages of this technique are given and indications and contraindications for this diagnostic adjunct are discussed. A simple method involving the use of inexpensive equipment in the office is suggested.

Cell Nucleus↗