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Biomedical subjects

M L Albert

Publications and source records attributed to M L Albert.

89 records · Page 5Linked to original sources

The 'subcortical dementia' of progressive supranuclear palsy.

Progressive supranuclear palsy (Steele et al.) has a characteristic pattern of dementia: (1) forgetfulness, (2) slowing of thought processes, (3) emotional or personality changes (apathy or depression with occasional outbursts of irritability), and (4) impaired ability to manipulate acquired knowledge. In many neurological disease states associated with subcortical pathology a similar pattern of dementia exists. The neurobehavioural changes of progressive supranuclear palsy thus typify a clinical pattern which may be referred to as subcortical dementia. The subcortical dementias have a striking clinical resemblance to the dementia which occurs after bifrontal lobe disease. However, the subcortical dementias can be clearly distinguished clinically from cortical dementias, other than frontal dementias. We propose as a tentative hypothesis that there may be common pathophysiological mechanisms underlying the subcortical dementias-in particular, disturbances of timing and activation. There are immediate practical implications of this hypothesis: drugs which have an effect on subcortical timing and activating mechanisms may be useful in the treatment of subcortical dementias.

Affective Symptoms↗

Enlargement of the Sylvian aqueduct: a sequel of head injuries.

A review of pneumoencephalography and clinical data in a large group of patients has shown that severe head injury may be followed by a consistent clinical-radiological syndrome. A prolonged period of unconsciousness is a characteristic initial feature of this syndrome. Clinically there is ataxia and dysarthria and, often, abnormal movements and oculomotor dysfunction. The characteristic radiological feature is an enlargement of the aqueduct of Sylvius. The clinical picture, together with the enlargement of the aqueduct, suggests that loss of neuronal and axonal substance in the midbrain is the probable pathology.

Adult↗

Case-based teaching and learning experiences.

Case-based teaching and learning strategies can be utilized to assist advanced practice psychiatric nursing students in both obtaining requisite knowledge and enhancing clinical reasoning skills. We discuss the benefits of case-based learning in terms of how it (1) contributes to students' appropriate organization of information to be recalled later for use in clinical reasoning situations; (2) generates experiences that students would not otherwise have; (3) increases the visibility of students' clinical reasoning processes; and (4) enhances students' confidence. This article also explores three examples of case-based teaching and learning: use of written cases in a seminar; use of standardized patients in an assessment course; and utilization of web-based cases for learning assessment and intervention skills. Finally, we compare and contrast each of these methods in terms of their relative effectiveness in achieving each of the benefits.

Computer-Assisted Instruction↗