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Biomedical subjects

M Kyriakos

Publications and source records attributed to M Kyriakos.

At least 73 records · Page 4Linked to original sources
PubMed1980

Intracortical osteosarcoma.

A case of osteosarcoma is described that originated within the cortex of the tibial diaphysis. This form of osteosarcoma was first described by Jaffe as "intracortical osteogenic sarcoma." A review of the literature indicates that this is probably the rarest presenting form of osteosarcoma. It appears to have a predilection for origin in the diaphysis, and its radiologic appearance may mimic a benign lesion. Follow-up information is given on the two cases originally reported by Jaffe, and the tumor is distinguished from periosteal osteosarcoma with which it has recently been confused.

Adolescent↗
PubMed1980

Ossified skeletal muscle hemangioma: radiologic and pathologic features.

Skeletal muscle hemangiomas are relatively uncommon tumors in children and young adults. Although the operative management of these lesions may be affected by their vascularity, the correct preoperative diagnosis is often not made. Ossification of these lesions is rare. Two patients are described whose skeletal muscle hemangiomas contained abundant osseous tissue. This was radiologically reflected by the 'swiss cheese' appearance of the tumors. Such an appearance in an ossified soft tissue mass may allow the correct preoperative diagnosis of this condition.

Adult↗
PubMed1980

Fibrous histiocytoma (fibroxanthoma) of a cervical vertebra. A report with a review of the literature.

A patient with a benign appearing intraosseous fibrous lesion of the cervical vertebra is presented. The lesion had the histologic features of non-ossifying fibroma (metaphyseal fibrous defect). Because of its atypical location and unusual radiologic appearance, the lesion was diagnosed as a fibrous histiocytoma, a tumor whose histology is similar to non-ossifying fibroma. The literature was reviewed for similar cases located outside the metaphysis of the long bones. Support is given for designating such lesions as fibrous histiocytomas rather than non-ossifying fibromas.

Adult↗
PubMed1979

Soft tissue implantation of chondromyxoid fibroma.

While chondroblastoma, a usually benign cartilaginous bone tumor that has histologic features in common with chondromyxoid fibroma, can invade or be accidentally implanted in the soft tissues, it is less well known that this may also occur with chondromyxoid fibroma. A patient is described in whom a chondromyxoid fibroma recurred in the superficial soft tissues following prosthetic replacement of the upper femur. This is only the second such case reported without a simultaneous recurrence within the adjacent bone. The close association of the soft tissue tumor with suture fragments is taken as evidence for implantation at the time of operation. A unique histologic feature was the presence of vascular invasion within the implant. The literature on soft tissue involvement by chondromyxoid fibroma is reviewed and the meaning of this in terms of malignancy is discussed.

Adult↗
PubMed1979

Pulmonary oat cell carcinomas. Expression of plasma membrane antigen correlated with presence of cytoplasmic neurosecretory granules.

A plasma membrane antigen highly associated with pulmonary oat cell carcinoma has recently been identified. Expression of this surface antigen was now examined in routine surgical pathology material from 32 primary lung tumors by immunostaining. The staining patterns of 17 tumors diagnosed as oat cell carcinoma by light microscopy were compared to those of 10 epidermoid carcinomas, four carcinoid tumors, and one lymphocytic lymphoma. In addition, when available, the oat cell carcinoma group was also studied by electron microscopy for demonstration of cytoplasmic neurosecretory granules. Twelve of the 17 oat cell carcinomas and one of the epidermoid carcinomas expressed the antigen. In this group of small cell tumors of the lung, aggrement was found between the expression of this immunochemical marker and the presence of neurosecretory granules in the cytoplasm of the tumors. Demonstration of this surface antigen in routine surgical pathologic material may be a useful aid in the diagnosis of these tumors. The failure of a group of tumors, which satisfied the light microscopic criteria for oat cell carcinoma to stain for the antigen, demonstrates heterogeneity within the oat cell carcinoma group.

Antigens, Neoplasm↗
PubMed1978

Oat-cell carcinoma of the larynx.

The diagnoses of three cases of laryngeal oat-cell carcinoma were confirmed by electron microscopy. As in pulmonary oat-cell carcinoma, the prognosis in these cases is poor; of our three cases and the previously reported cases of this tumor type in the larynx, all but one of the patients, for whom there is adequate follow-up information, have died of widespread metastases. Aggressive radiation therapy and systemic chemotherapy appear indicated if improved survival is to be achieved.

Bone Neoplasms↗
PubMed1978

Enteritis cystica profunda.

In addition to hamartomatous polyps of the small intestine, a patient with Peutz-Jeghers disease had gross and microscopic lesions of the ileum that were analogous to colitis cystica profunda in the large intestine and rectum. To the authors' knowledge, this is the first such case in an adult to be reported. They suggest the designation, "enteritis cystica profunda." The histology of the lesions and their association with a disease known to produce hamartomatous lesions lend support to the proposition that some cases of colitis cystica are also hamartamatous. It is also believed that some reported cases of small-intestinal adenocarcinoma in patients with Peutz-Jeghers syndrome are in reality examples of the benign process of enteritis cystica profunda.

Adenocarcinoma↗
PubMed1977

Myospherulosis of the paranasal sinuses, nose and middle ear. A possible iatrogenic disease.

Sixteen cases of myospherulosis, a disease of unknown etiology previously reported only from East Africa, were found in the St. Louis metropolitan area. Although the disease in Africa occurred in the peripheral deep and superficial soft tissues, in St. Louis it involved the paranasal sinuses, nose, and middle ear. All patients had previously had surgical procedures involving the regions subsequently shown to contain the structures of myospherulosis. A common denominator in these cases was the operative use of hemostatic packing containing petrolatum-based ointments and gauze. These ointments, usually containing an antibiotic, were nonsterile. This raised the possibility that the as yet unidentified structures of myospherulosis may be introduced via these petrolatum-based substances.

Adolescent↗
PubMed1977

Myospherulosis. An electron-microscopic study of a human case.

An electronmicroscopic study of a human case of myospherulosis, which involved the nose and maxillary sinus, is reported. Large parent bodies limited by a thick electron-dense wall, enclosing variable numbers of spherules, were seen in cystic tissue spaces or adjacent connective tissue. Free spherules and shrunken degenerative forms were present as well. Similarity of these bodies to sporangium-like structures is suggested. The etiology of the disease remains unsettled.

Adult↗
PubMed1977

The induction of human myospherulosis in experimental animals.

Tissue lesions similar to those in human myospherulosis were reproduced in experimental animals and studied by light and electron microscopy. The lesions were produced by the use of petrolatum-based antibiotic ointments. These ointments, which are marketed as nonsterile products, are similar to those used for hemostatic packing in otolaryngologic surgery. To date, use of these ointments has been reported to precede the finding of human paranasal sinus myospherulosis. The exact nature of the structures of myospherulosis remains unknown. The experimental evidence strongly suggests that they can be iatrogenically produced by the use of these nonsterile ointments.

Animals↗
PubMed1976

Inflammatory fibrous histiocytoma. An aggressive and lethal lesion.

During an investigation of soft tissue fibrohistiocytic tumors, seven cases were found which we believe represent a new and specific diagnostic subgroup of fibrous histiocytomas. All patients were adults (mean 52.6 years), only one of whom was younger than age 40. There were four females and three males; all were Caucasian. The tumors which occurred in the retroperitoneum, anterior chest wall, anterior abdominal wall, femoral area, and oral cavity, were large, averaging 8.5 cm., and although appearing encapsulated, were microscopically infiltrative. The common histologic feature of all cases was a diffuse and at times intense neutrophilic infiltrate unassociated with tissue necrosis, in combination with bland and anaplastic appearing histiocytes. The presence of this acute exudative reaction is a unique feature of these lesions, and was present not only in the original tumors, but in recurrences and metastatic foci as well. Other cell types including foam cells, lymphocytes, plasma cells, eosinophils, Reed-Sternberg-like and ganglion-like cells were commonly present. A storiform fibrous pattern, a hallmark of the fibrous histiocytomas was seen at some time in all but one case. The treacherous aspect of these lesions was their bland initial histologic appearance. The foci of foam cells associated with the inflammatory elements often led to a diagnosis of a benign inflammatory reaction or xanthogranuloma. However, follow-up has confirmed the aggressive and neoplastic nature of these lesions. The clinical course was usually protracted with multiple recurrences and eventual metastases. All patients died of their tumor, the average survival being 53 months; four patients survived over 5 years. At this time, we propose the term inflammatory fibrous histiocytoma to designate these lesions.

Adult↗
PubMed1975

Prevention of experimental allergic uveitis. Treatment and methotrexate.

These experiments were undertaken to determine if methotrexate therapy, initiated after immunization, could prevent the development of experimental allergic uveitis. Strain 13 guinea pigs were immunized with Strain 13 guinea pig retina-uvea extract that had been emulsified in Freund complete adjuvant. Some were treated with methotrexate twice a week until the 21st day. Each week, all of their eyes were examined with a slit-lamp. At the end of the study, some were skin tested, and the sera of selected animals were tested by immunodiffusion for antibody. The eyes of certain groups were examined histologically. Results show methotrexate prevented the development of this type of uveitis, even when therapy was initiated seven days after immunization. The disease did not appear after therapy was stopped. Methotrexate also inhibited the development of skin sensitivity and antibody to retina-uvea antigen.

Animals↗
PubMed1975

Differential susceptibility of strain 2 and strain 13 guinea pigs to induction of experimental autoimmune thyroiditis.

Twenty-seven of 30 Strain 2 guinea pigs immunized with 100 mug guinea pig thyroglobulin (GPTG) prepared either from Hartley (H) or Strain 13 (13) thyroids developed experimental autoimmune thyroiditis (EAT) whereas only 1 of 39 similarly immunized Strain 13 guinea pigs developed EAT. F1 hybrids behaved like the Strain 2 parent in that 16 of 20 developed EAT. The susceptible Strain 2 and F1 guinea pigs had higher hemagglutinating antibody titers to GPTG than the Strain 13 guinea pigs whereas all three strains had similar delayed skin reactivity to GPTG. The results suggest that susceptibility of guinea pigs to thyroiditis is genetically controlled and that production of antithyroglobulin antibody may be important in determining disease susceptibility.

Animals↗