Search PubMed⌕ Search

Biomedical subjects

M Kuwabara

Publications and source records attributed to M Kuwabara.

At least 307 records · Page 17Linked to original sources

Bile acid profiles in bile, urine, and feces of a patient with cerebrotendinous xanthomatosis.

Bile acid profiles of bile, urine, and feces obtained from a patient with cerebrotendinous xanthomatosis on the same day have been analyzed by gas-liquid chromatography-mass spectrometry after fractionation into groups by mode of conjugation by an ion-exchange chromatography. The predominant biliary bile acid was cholic acid conjugated with glycine and taurine. Lesser amounts of the amino acid conjugates of chenodeoxycholic acid, ursodeoxycholic acid, 7-ketodeoxycholic acid, allocholic acid, and deoxycholic acid, and of unconjugated norcholic acid and allonorcholic acid were also present in the bile. The major fecal bile acid was 7-epicholic acid. Relatively large amounts of bile acids were excreted in the urine. Unconjugated 7-epicholic acid, norcholic acid, allonorcholic acid, and cholic acid predominated. The bile acid profiles of the patient were different from those of normal subjects and should be useful for the diagnosis.

Bile↗

A new mutant rat with turning behavior (Tur).

A new rat mutant with abnormal behavior has been found in a closed colony of Slc: SD. The affected rats turned around after their own tails beginning 4-5 weeks after birth, in response to extroceptive stimuli, such as sound or vibration. The behavior was more pronounced in younger animals. On gross observation, no alteration was found in the cerebrum, cerebellum, or anterior, posterior, or lateral semicircular canals. Light microscopic examination revealed no abnormality in the cerebrum or cerebellum. The trait was controlled by an autosomal dominant gene with incomplete penetrance (78.0%) when transferred to the WKY genetic strain background. It was named "turning" with the gene symbol Tur. A congenic strain was established, which was designated WKY/Eis-Tur.

Animals↗