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Biomedical subjects

M Kuro

Publications and source records attributed to M Kuro.

At least 37 records · Page 2Linked to original sources
PubMed1999

[Anesthetic management of left ventricular reduction surgery (Batista procedure)].

We experienced anesthetic management of left ventricular reduction surgery (Batista procedure) which is a newly developed procedure for treating end-stage dilated cardiomyopathy. The patient was a 41-year-old man who had been suffering from cardiac failure and refractory ventricular tachycardia. The anesthesia was induced and maintained with meticulous administration of fentanyl. After resection of the left ventricular free-wall, the left ventricular diastolic diameter decreased to 46 mm, from 79 mm of preoperative measurement. Weaning from cardiopulmonary bypass was successful with the use of catecholamines and intra-aortic balloon pumping. Administration of both vasodilators and phosphodiesterase inhibitors such as milrinone also contributed to reducing afterload and maintaining cardiac output. In addition to standard hemodynamic monitoring, transesophageal echocardiography provided invaluable information on determining cardiac dimensions and evaluating left ventricular wall motion.

Adult↗
PubMed1999

[Anesthetic management for implantation of implantable cardioverter-defibrillators].

Implantable cardioverter-defibrillators (ICDs) were implanted in 44 patients at the authors' institution. The anesthetic management was reviewed retrospectively. Ten of the 44 patients received the third generation ICD devices, while the rest received the fourth generation devices. For thirteen patients receiving the fourth generation devices, implantation was performed under local anesthesia with monitored care of anesthesiologists. Propofol was infused to achieve deep sedation during induced ventricular fibrillation and later cardioversion for testing the devices. Implantation was performed under general anesthesia with combination of fentanyl and volatile anesthetics for the remaining 31 patients. Patients who received ICDs under local anesthesia had significantly greater values of ejection fraction in preoperative examination than values in patients who received ICDs under general anesthesia. Operation time of the implantation under local anesthesia was significantly shorter than that under general anesthesia. Though infusion of propofol produced a moderate decrease of blood pressure in patients who received ICDs under local anesthesia, no patient showed major complication. Local anesthesia with sedation with propofol can be an option in anesthetic management for implantation of an ICD if an anesthesiologist cares the patient whose cardiac function is not compromised.

Adult↗
PubMed1999

[Anesthetic management of patients undergoing implantation of left ventricular assist system].

We examined the anesthetic management of six patients with end-stage dilated and hypertrophic cardiomyopathy for implantation of left ventricular assist system. Although anesthesia was induced only with fentanyl or with combination of fentanyl and diazepam, hemodynamic changes after the anesthetic induction were variable and preoperative evaluation of left ventricular ejection fraction did not predict the hemodynamic changes. After the weaning from cardiopulmonary bypass, the right ventricular support by catecholamines, such as dopamine and dobutamine, and phosphodiesterase III inhibitors, such as amrinone, and pulmonary vasodilation by inhalation of nitric oxide were useful to maintain volume loading to the left ventricular assist system.

Adolescent↗
PubMed1999

[Anesthetic management for carotid and coronary artery surgery--concomitant versus two stage operation].

We reviewed the anesthetic management of 16 patients with concomitant severe coronary and carotid artery diseases. Eight patients underwent concomitant operations of coronary artery bypass graft and carotid endarterectomy, while the other 8 patients underwent two stage operation. Candidates for concomitant operations had unstable angina or serious coronary disease such as three vessel disease or severe stenosis of LMT. In comparison, most of patients undergoing two stage operation had symptomatic or occlusive carotid disease. In all cases, anesthesia was maintained with fentanyl and midazolam and the perfusion pressure during cardiopulmonary bypass was maintained above 70 mmHg. Some patients received thiopental or propofol for brain protection. The concomitant operations required much more transfusion and longer operation time than two stage operation. In addition, several cases of the concomitant operation needed intra-aortic balloon pumping or high dose of catecholamines. Indications for concomitant operation or two stage operation have to be determined through discussion among anesthesiologist, neurovascular as well as cardiovascular surgeons.

Aged↗
PubMed1999

Effects of thiopental, ketamine, etomidate, propofol and midazolam on the production of adrenomedullin and endothelin-1 in vascular smooth muscle cells.

Endothelin-1 (ET-1) and adrenomedullin (AM) are potent vasoconstrictive and vasodilative peptides. Vascular smooth muscle cells are one of the major producing tissues of these peptides. We investigated effect of thiopental, ketamine, etomidate, midazolam and propofol on the production of ET-1 and AM in cultured rat aorta vascular smooth muscle cells. Rat cultured vascular smooth muscle cells are used and the dose-dependent effect (10(-8)-10(-4) M) of thiopental, ketamine, etomidate, midazolam, and propofol on the production of ET-1 and AM was examined. The concentration of these peptides in the culture medium were measured by radioimmunoassay. Ketamine, etomidate, propofol and midazolam, but not thiopental, decreased the production of ET-1 at a concentration of 10(-4) M and the effect of midazolam is the most potent. Thiopental and etomidate produced small but significant increases in the production of AM at a concentration of 10(-4) M. Ketamine did not affect the production, but propofol and midazolam decreased the production at 10(-4) M and 10(-5) M, respectively. These results suggest that thiopental, ketamine, etomidate, propofol and midazolam differentially affect the production of ET-1 and AM in rat vascular smooth muscle cells.

Adrenomedullin↗
PubMed1998

[Early recovery after valvular heart surgery].

There have been published not a few reports concerning the early recovery from heart surgery. But most of them were restricted in CABG cases. We report our efforts and its results about the early recovery from valvular heart surgery. To make a contribution to the early recovery we have made some efforts since 1995, including normothermic perfusion, low-dose fentanyl and introduction of terminal warm blood cardioplegia. As the results, the tracheal intubation period was shortened from 12.6 +/- 5.3 (hour) to 6.7 +/- 4.1. The number of the cases who had tracheal extubation in the operative day increased from 27% to 84%. The postoperative cardiac function was satisfactory and there were no abdominal or neurologic disturbances among the patients those who were entered into the early recovery protocol. We obtained satisfied early recovery in safe after valvular heart surgery.

Aortic Valve↗
PubMed1998

Increased plasma adrenomedullin concentrations during cardiac surgery.

1. Adrenomedullin (AM), a potent hypotensive peptide, was originally isolated from human phaeochromocytoma. Plasma AM concentrations are elevated in hypertension, heart failure and renal failure in proportion to the severity of the disease. This study was performed to investigate the pathophysiological significance of AM during cardiac surgery. 2. Serial blood samples were obtained from patients undergoing cardiac surgery and plasma AM concentrations were determined by specific radioimmunoassay. 3. Plasma AM concentrations did not increase with anaesthesia or surgery (n = 9). Plasma AM concentrations gradually increased during cardiopulmonary bypass and after pulmonary reperfusion. After pulmonary reperfusion, plasma AM concentrations increased further. In addition, we measured plasma AM concentrations in the pulmonary vein (n = 8) and coronary sinus (n = 8) to examine the contribution of the lungs and heart to the increase in circulating AM concentrations after cardiopulmonary bypass. However, no significant differences were seen in plasma AM concentrations of the pulmonary vein or the coronary sinus and the aorta. Peak AM concentrations during cardiac surgery correlated with duration of surgery. Elevated plasma AM levels during and after surgery began to decline next day after surgery and returned to normal levels 7 days after surgery. 4. These results demonstrate that plasma AM concentrations increase during cardiac surgery and that the duration of surgery may be related to the changes in AM concentrations. Taken together with recent findings that vascular endothelial cells and vascular smooth muscle cells actively produce AM, these results suggest that plasma AM during cardiac surgery may act as a vasodilatory hormone.

Adrenomedullin↗
PubMed1998

Evaluation of platelet function by Sonoclot analysis compared with other hemostatic variables in cardiac surgery.

UNLABELLED: Platelet function can be easily measured as time to peak (TP) by Sonoclot Coagulation & Platelet Function Analyzer (Sienco Inc., Morrison, CO) analysis. However a correlation between Sonoclot analysis and platelet aggregation, which is accepted as a test of platelet function, has not been established. In this study, we compared TP and collagen-induced whole blood platelet aggregation in 15 patients undergoing cardiac surgery. Two or three blood samples were randomly obtained from each patient before and after cardiopulmonary bypass (CPB). Sonoclot analysis, collagen-induced whole blood aggregation, and laboratory measurement (including platelet count and coagulation profile) were measured. Seventy-two samples were obtained (35 before CPB and 37 after CPB). TP was correlated with collagen-induced whole blood aggregation (r = -0.652), platelet count (r = -0.671), fibrinogen level (r = -0.598), prothrombin time (r = 0.394), activated partial thromboplastin time (r = 0.486), and use of CPB (r = 0.380). Significant predictors of TP for multiple linear regression modeling were collagen-induced whole blood aggregation, platelet count, and fibrinogen level (r = 0.742). In conclusion, Sonoclot analysis TP predicts approximate platelet function in patients undergoing cardiac surgery. IMPLICATIONS: Approximate platelet function can be easily measured as time to peak by Sonoclot analysis. In this study, time to peak was predicted by platelet count, whole blood platelet aggregation, and fibrinogen level for multiple linear regression modeling.

Cardiac Surgical Procedures↗
PubMed1998

Incidence of venous and paradoxical air embolism in neurosurgical patients in the sitting position: detection by transesophageal echocardiography.

BACKGROUND: Venous air embolism (VAE) and paradoxical air embolism (PAE) are serious complications associated with the sitting position for neurosurgery. Although PAE is the result of VAE, the incidence of PAE according to the severity of VAE has not been investigated systematically in humans. METHODS: Twenty-one patients scheduled for neurosurgery in the sitting position were investigated prospectively. VAE and PAE were continuously monitored by cardiac two-dimensional 4-chamber view using transesophageal echocardiography (TEE) and the severity of VAE and PAE was quantitatively graded from 0 to 3 by the microbubbles score. Haemodynamic parameters and end-tidal CO2 concentration (PETCO2) during VAE and PAE were also recorded. RESULTS: Microbubbles in the right atrium appeared in all patients and the number of patients involved in grades 0, 1, 2 and 3 of VAE was 0, 10, 3 and 8, respectively. PAE occurred in 3 patients and only followed grade 3 of VAE. PAE always appeared from 20 to 30 s after the most severe VAE. A reduction of PETCO2 and an increase of pulmonary artery pressure were noted during all episodes of grades 2 and 3 VAE. In contrast, a significant reduction of systemic blood pressure occurred in 1 case of grade 2 and 3 cases of grade 3. CONCLUSIONS: VAE detected by TEE appeared in all patients undergoing neurosurgery in the sitting position and PAE only occurred following the most severe grade of VAE. To prevent growth of VAE is an important prophylactic for PAE.

Adolescent↗
PubMed1998

[A successful perioperative anticoagulation therapy and monitoring of a patient with hereditary plasminogen abnormality undergoing aortic valve replacement].

During perioperative period, plasminogen abnormality can result in unusual or unexplained clotting that occurs spontaneously or after minor trauma. However, there has been no report on perioperative anticoagulation therapy and monitoring in patients with hereditary plasminogen abnormality undergoing cardiac surgery. We performed a successful perioperative anticoagulation therapy and monitoring of a patient with hereditary plasminogen abnormality undergoing cardiac surgery. A 48-year-old male patient with severe aortic valve stenosis, who had had no episode of thrombosis, was scheduled for aortic valve replacement Preoperative laboratory screenings detected his abnormal plasminogen activity (7.6% normal), and he was diagnosed as hereditary plasminogen abnormality. Anesthetic course was uneventful until the initiation of cardiopulmonary bypass (CPB). During CPB, heparin level was monitored every 30 minutes by Hepcon/HMS (Medtronic Hemotec, Parker, CO). No thrombus was observed in the CPB circuit. Plasminogen activity, fibrin degradation products (FDP) and D-dimer were not elevated during perioperative period. Protamine dosage was determined by protamine titration method, and protamine was administrated after the termination of CPB. No major bleeding was observed after protamine administration. When the patient was admitted to ICU, anticoagulation therapy was started immediately. During perioperative period, no episode suggesting thrombosis was observed. In conclusion, we consider that this successful anticoagulation therapy and monitoring during CPB has been achieved by use of Hepcon/HMS.

Anesthesia, General↗
PubMed1998

[Anesthetic management for Fontan procedure without the use of cardiopulmonary bypass].

We examined the anesthetic management for Fontan procedure performed without the use of cardiopulmonary bypass (Group N, n = 7) and that for equivalent procedure under cardiopulmonary bypass (Group E, n = 10) retrospectively. In Group N, surgical repairs of major vascular system were performed while bypassing the superior or inferior vena cava to the right atrium. The use of anesthetics and vasoactive agents was similar in both groups. Patients in Group N had significantly less blood loss and were extubated significantly earlier than those in Group E. However, significant metabolic acidosis was noted in Group N when reconstruction of the vascular system was completed and so-called Fontan circulation was initiated. Fontan procedure without the use of cardiopulmonary bypass may have advantage of less impairment for the cardiac performance and the pulmonary vasculature. However, its anesthetic management is another challenge to the anesthesiologist and requires meticulous control of both optimum preload and vascular resistance of the pulmonary artery.

Anesthesia, General↗
PubMed1998

[Effects of changes in head and neck position on a tracheal tube cuff].

Thirteen patients were intubated with cuffed reinforced spiral tracheal tubes. Intracuff pressure and volume were measured as the position of the head and neck was altered. No significant changes in intracuff pressure and volume were observed with lateral rotation of the head. A significant increase in intracuff pressure was observed and excessive pressure (> 25 cm H2O) developed in 8 patients with head and neck flexion. A significant decrease of intracuff pressure and air-leak were observed in 9 patients with extension. Reinflated intracuff volume decreased and reinflated intracuff pressure increased significantly, and residual excessive pressure was observed in 4 patients with flexion. Both reinflated intracuff volume and pressure increased significantly, and excessive pressure was observed in 8 patients and residual air-leak developed in a patient in spite of excessive pressure with extension. The authors speculate that endotracheal tube movement by changes in head and neck position has effects on intracuff pressure and volume.

Aged↗
PubMed1997

A guide to preventing deep insertion of the cannulation needle during catheterization of the internal jugular vein.

OBJECTIVE: Accidental puncture of the vertebral artery during the internal jugular vein cannulation produces lethal sequelae. To prevent this, the cannulation needle must not be inserted too deeply. However, there is no useful guide for the optimal length of insertion of the needle for accessing the internal jugular vein. The authors examined the length of the needle needed to reach the internal jugular vein with three different sizes of needle (16, 20, and 23 gauge). DESIGN: Prospective study. SETTING: An academic medical center. PARTICIPANTS: Patients undergoing cardiovascular surgeries. INTERVENTIONS: The cannulation of the internal jugular vein was performed through the right internal jugular vein by the high approach. The needle was slowly advanced, keeping constant negative pressure on the syringe at 45 degrees to the skin surface until blood was aspirated; if blood was not aspirated during insertion, the needle was slowly withdrawn until blood was aspirated. The distance to the internal jugular vein was assessed by calculating the entire length of needle minus the length of needle from the skin surface to the hub. MEASUREMENTS AND MAIN RESULTS: The mean distance to the internal jugular vein ranged from 15.0 to 21.5 mm, and the larger needle required the longer distance to the internal jugular vein. CONCLUSIONS: The results may be a useful guide to prevent too deep insertion of the needle during internal jugular vein catheterization, especially when teaching residents who have limited experience with internal jugular vein catheterization.

Catheterization, Central Venous↗
PubMed1997

Resection of a large, high-flow arteriovenous malformation during hypotension and hypothermia induced by a percutaneous cardiopulmonary support system. Case report.

The key to successful surgical resection of cerebral arteriovenous malformations (AVMs) is control of bleeding and cerebral swelling. Induced hypotension is one of the most valuable means of achieving this control. The authors introduced induced hypotension with mild hypothermia by using a percutaneous cardiopulmonary support system (PCPS) to resect a large, high-flow AVM. The efficacy and technical points of this method are discussed. The PCPS, whose entire intraluminal surface was coated with heparin, was established through a transfemoral route. During resection of the AVM, a mean arterial blood pressure of 60 mm Hg and a mean body temperature of 30 degrees C were easily maintained by regulating the flow rate of the PCPS and by blood cooling. The activated coagulation time was maintained at approximately 250 seconds with a minimum systemic administration of heparin. The authors report the case of a 30-year-old woman who presented with intraventricular hemorrhage and was diagnosed as having a large, high-flow AVM located in the left sylvian fissure. The AVM was fed by the left middle, posterior, and anterior cerebral arteries and drained by the many cortical ascending veins and the basal vein. The patient underwent surgery after hypotension and hypothermia had been induced via the PCPS method. Induced hypotension decreased the tension of the nidus and made its dissection easier. The AVM was totally resected and no hemostatic difficulties were encountered. On the basis of the authors' experience, they suggest that hypotension and hypothermia induced by using the PCPS is a powerful tool for the successful resection of large, high-flow AVMs.

Adult↗
PubMed1997

[Anesthesia for pediatric open heart surgery without transfusion].

We reviewed 50 recent anesthetic managements of pediatric patients for open heart surgery weighing between 6.5 to 12 kg to evaluate factors contributing to successful management without transfusion. Twenty six cases were managed without transfusion, whereas nine cases required less than 30 ml.kg-1 of transfusion and the other 15 cases needed massive transfusion amounting to more than 50 ml.kg-1. The followings are important factors to complete the open surgery without transfusion; 1) the patient's weight is 9 kg or more, 2) the duration of cardiopulmonary bypass is less than 120 minutes, and 3) intraoperative bleeding is less than 10 ml.kg-1. We could find several advantages in patients without transfusion, compared with those receiving transfusion, such as greater urine output, less bleeding during the surgery, more concentrated platelet and better respiratory condition after the surgery. In addition, the lager the amount of transfusion we observed the more disadvantageous to the patients. Even if transfusion can not be avoided, minimal transfusion of the washed red cell is favorable.

Anesthesia, Inhalation↗
PubMed1997

[A case of twice catastrophic pulmonary vasoconstriction-type shock induced with protamine sulfate].

A 71-year-old female was scheduled for the re-replacement of a mechanical mitral valve. After the cardiopulmonary bypass (CPB) she was administered protamine sulfate. Subsequently mean systemic blood pressure went down below 20 mmHg and central venous pressure and mean pulmonary blood pressure were above 50 mmHg, and immediately CPB was restarted as an assist device for circulation. After the second CPB, she was administered protamine sulfate again, and the same shock occurred. At last the third CPB was restarted and the third protamine administration was not undertaken after the third CPB. Although her postoperative drainage may have been relatively much more compared with cases of neutralization of heparin, postoperative course was uneventful in this patient. Administered protamine to neutralize the anticoagulat effects of heparin may often cause temporary treatable hypotension. Although protamine may rarely cause severe pulmonary vasocontriction and anaphylactoid reactions, clinical pictures become critical once these reactions occur. It is important in these cases to identify protamine as the cause of shock and avoid repeating the shocks.

Aged↗