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Biomedical subjects

M Kurihara

Publications and source records attributed to M Kurihara.

At least 325 records · Page 18Linked to original sources
PubMed1981

Diagnosis of small early gastric cancer by X-ray, endoscopy, and biopsy.

Cases of early gastric cancer detected over a span of 12 years were reviewed for three periods: 1968-71, 1972-74, 1975-79. Early gastric cancers detected in each period were compared by size, type, and accuracy of diagnostic techniques consisting of barium meal double contrast radiography, gastroscopy, and biopsy. Eighty-five lesions were detected in the first period, 101 in the second, and 237 in the third, in a total of 369 patients. The number of detected early gastric cancers less than 10 mm in diameter also increased in each period. The study indicated that emphasis should be placed on careful radiographic and gastroscopic analysis of slight mucosal abnormalities in order to detect small early gastric cancer with greater accuracy.

Biopsy↗
PubMed1979

Gastric carcinoma in dogs produced by the combined use of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and gastrin--with special reference to development of scirrhous carcinoma.

Eight beagle dogs of four-month-old received both oral administration of N-Ethyl-N'-Nitro-N-Nitrosoguanidine (ENNG) and subcutaneous injection of gastrin, and one of them was found to have an annularly infiltrating advanced carcinoma with marked fibrous thickening of the antral wall resulting in stenosis of the antrum (carcinoma scirrhosum) which resembled "Linitis plastica" (Borrmann's type IV carcinoma) in human stomach.

Adenocarcinoma, Scirrhous↗
PubMed1979

National cancer mortality and incidence in Japan.

In Japan cancer mortality statistics have been prepared by site, sex, and age group since 1937. The trends in age-adjusted death rates for selected sites from 1937 to 1975 in intervals of two or three years, and the age-adjusted death rates for some sites by prefecture in 1968-1972 were summarized. Concerning the accuracy of cancer mortality statistics, special consideration should be given to senility in Japan. In 1975 deaths due to senility accounted for 4.3% of all deaths for all ages. Though the regional cancer registration was being operated in 16 prefectures in Japan as of 1976, the incidence rates were published for only six prefectures. The percentage of cases registered from death certificate only in six registries in Japan was compared with that in the registries in the United States, indicating that the completeness of registration was yet unsatisfactory in Japan. As an index of accuracy of diagnosis, the percentage of cases confirmed histologically was also compared.

Age Factors↗
PubMed1977

Adenocarcinomas of the stomach induced in beagle dogs by oral administration of N-ethyl-N'-nitro-N-nitrosoguanidine.

Two 8-month-old and two 4-month-old male beagle dogs received 250 ml of 150 microgram/ml solution of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and 2% Tween 60 mixed with a pellet diet twice a day for 8 months as the same methods used for mongrel dogs in our first report [Juntendo Medical Jouranl 19, 579-583 (1973)]. Gastric carcinomas with distant lymph nodes metastases occurred in three beagle dogs except for one died from anesthesia at the endoscopy. Metastases to the liver were observed in two beagles. In the most long-lived beagles, peritonitis carcinomatosa with ascites and metastases to the liver, lungs, bones, and skin were found. Main gastric tumors were located at the subcardia in two dogs (elevated tumor in dog No. 6, ulcerated tumor in dog No. 8), but in dog No 7 at the angulus (ulcerated tumor). Histologically, carcinomas were composed of poorly differentiated adenocarcinoma, signet-ring cell carcinoma, tubular adenocarcinoma, and undifferentiated adenocarcinoma. In all of three dogs which developed adenocarcinoma of the stomach, Stewart's criteria were completely satisifed. Using our methods the target organ is limited only to the stomach, without any sarcomatous lesion of the intestines.

Adenocarcinoma↗