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Biomedical subjects

M Kuniyoshi

Publications and source records attributed to M Kuniyoshi.

43 records · Page 3Linked to original sources
PubMed1979

Frontal kindling in rabbits and its influence on visual and auditory evoked response.

Frontal kindling in rabbits, prolongation of the duration of afterdischarge concomitant and clinical manifestations and the epileptic foci (primary and independent secondary foci) were revealed. Auditory and visual evoked responses were recorded after completion of the kindling phenomenon. 1. Electrical stimulations, 300 microA, 60 Hz. 1 msec in duration, 2 sec train, were applied once a day. Clinical manifestations were divided into five stages: 1) the arrest of behavior or no response, 2) the adversive movement with a tonic and/or clonic convulsion of left paw, 3) the adversive movement following mastication, facial spasms and postictal stupor, 4) falling down abruptly and generalized convulsive seizure, and 5) generalized seizure followed by rotatory movement, vocalization and myoclonus. The appearance of five generalized convulsions was defined as a completion of the kindling phenomenon. 2. The duration of afterdischarge increased stepwisely from 2--3 sec to more than 400 sec. However, there was no constant duration of AD even though the animal showed generalized convulsion after completion of the kindling phenomenon. 3. Visual and auditory evoked responses were recorded after completion of kindling. There was a change in the auditory evoked response but not in the visual. A shortening of the latency of P2 component (73.3 msec in peak latency), N2 component (146.7 msec in peak latency) and amplification of the amplitude of N2 component were noticed. Thus, the intermittent weak electrical stimulation on the frontal cortex in rabbits induced generalized convulsion and produced primary and independent secondary epileptic focus on EEG, and the change of auditory evoked response was recognized in kindled animals.

Animals↗
PubMed1979

A study on dermatoses due to tonsillar focal infection using a nation-wide questionnaire in Japan.

The relation of the infected to nephritis, rheumatic and heart diseases has been recognized but that to dermatoses has not been fully established nor applied clinically by dermatogists or otolaryngologists in the treatment of such patients. In order to assess to attitude of dermatologists as regards the dermatoses due to focal tonsillar infection, a questionnaire was sent to the departments of dermatology of 72 universities in Japan: 44 (61.1%) have replied. There were 40 dermatoses listed as possibly associated with a focal infection. About 60% of the universities endeavoured to detect the focus although the focus was not always removed when identified.

Focal Infection↗
PubMedDate not supplied

Clinical significance of urinary N1,N12-diacetylspermine levels in patients with hepatocellular carcinoma.

BACKGROUND/AIM: N1,N12-diacetylspermine (DiAcSpm), a diacetylpolyamine which was recently identified in urine, appeared to be a useful tumor marker for urogenital cancers. Here we examined the clinical significance of urinary DiAcSpm as a tumor marker for hepatocellular carcinoma (HCC). METHODS: Urine samples were collected from patients with HCC and benign liver diseases. Urinary levels of DiAcSpm were measured by ELISA, which was newly developed in order to analyze large numbers of samples. RESULTS: The appropriate threshold value was set at 325 nM/g x creatinine. The sensitivity of the DiAcSpm assay for HCC was 65.5% and the specificity calculated between HCC and liver cirrhosis was 76.0%. The percentage of DiAcSpm-positive HCC patients was similar to that for AFP or PIVKA-II. At more advanced clinical stages, the positive percentage of these three markers increased but the DiAcSpm levels appeared to move independently of AFP and PIVKA-II. In HCC patients, the DiAcSpm levels reflected the progression of disease or the effect of treatment. CONCLUSIONS: DiAcSpm levels were found to reflect the severity, activity or viability of HCC. Urinary DiAcSpm can therefore be considered one of the useful indexes for patients with HCC.

Biomarkers↗