Search PubMed⌕ Search

Biomedical subjects

M Kudo

Publications and source records attributed to M Kudo.

At least 523 records · Page 29Linked to original sources
PubMed1977

Insulin and growth hormone secretion stimulated by intravenous administration of arginine in the low insulin responders (prediabetes?).

Twelve apparently healthy subjects who showed a low insulin response to glucose were selected from two different age groups, 6 from youngers aged 19 to 22 and 6 from olders above 65 years old, and responses of insulin and growth hormone secretion to an intravenous administration of arginine were investigated. Incidence of low insulin responders, who showed the peak value of plasma insulin during GTT below 45 muU/ml, was 9% among the young subjects and 24% among the old ones. Insulin secretion stimulated by arginine in 6 young low responders was not different from that in the control group matched with regard to age and body weight, and the values of growth hormone during arginine infusion were higher than those of the control group. In the old low insulin responders, insulin secretion stimulated by arginine was significantly lower than that in the control group, but the growth hormone secretion was not different from that in control. The present study showed that insulin and growth hormone secretion stimulated by arginine in young low-insulin-responders were different from those in the old ones. The low insulin responders are discussed in regard to prediabetes.

Adult↗
PubMed1976

Effects of trypsin on glucose-induced insulin secretion from the perfused rat pancreas.

The present study revealed that glucose-induced insulin secretion was significantly inhibited by perfusion with trypsin (10 mug/ml) in the isolated rat pancreas perfusion. However, when trypsin was interposed during perfusion of 16.6 mM glucose, glucose-induced insulin secretion was not suppressed during trypsin infusion. The insulin level was significantly lower in the trypsin treated animals than in the control after completion of trypsin infusion. The results suggest that trypsin does not attack the glucorecoptor bound with glucose but attacks the free glucoreceptor. Interestingly a biphasic pattern of glucose-induced insulin secretion disappeared by the pretreatment with trypsin. The possibility was suggested that tyrpsin prevented the initial binding of glucose to the B-cell.

Animals↗
PubMed1975

Effect of althesin (CT-1341) on thyroid-adrenal function in man.

The effects of althesin on adrenocortical and thyroid function were investigated by measuring plasma concentrations of cortisol, thyroxine (T4) and free thyroxine index (FTI) in 29 surgical patients. Althesin did not change the plasma cortisol concentrations from the preanaesthetic control value; however, the concentrations increased significantly after the start of surgery and thereafter. Althesin anaesthesia per se decreased slightly, but significantly, plasma T4 concentration, but did not influence the FTI value. The surgical operation increased the FTI value slightly but significantly. Our data would suggest that Althesin anaesthesia can be used in patients who have abnormal adrenocortical or thyroid activity.

Adolescent↗
PubMed1975

Secretory regulation of endocrine pancreas: Cyclic AMP and glucagon secretion.

Activation of adrenergic beta receptors has been found to stimulate insulin release in vitro that may be mediated through the augmentation of cyclic AMP in the beta cell. The activation of adrenergic alpha receptors in the beta cell inhibits the insulin release. The present studies have shown that isoproterenol (0.62 mug/ml) and sodium dibutyryl cyclic AMP (50 mug/ml) stimulate the insulin secretion and inhibit the glucagon secretion in the presence of 50 mg/100 ml glucose by the isolated pancreatic perfusion of the rat, while norepinephrine (0.5 mug/ml) inhibits the insulin secretion induced by 150 mg/100 ml glucose and stimulates the glucaton secretion. Theophylline (50 mug/ml) does not stimulate the insulin and the glucagon secretion. When norepinephrine is added to theophylline, the output of glucagon does not occur. From these results it can be deduced that the pancreatic alpha cell function may be inhibited by elevation of intracellular cyclic AMP, in contrast to the beta cell function which is stimulated by an increment of cyclic AMP.

Animals↗
PubMed1975

Inhibitory effects of synthetic rat C-peptide 1 on insulin secretion in the isolated perfused rat pancreas.

The effects of synthetic rat C-peptide 1 on insulin secretion from the isolated perfused rat pancreas was studied. The perfusion technique was according to the procedure described by Grodsky et al (1963) with a few modifications. After about 20 min of stabilization, the pancreas was perfused for 40 min with synthetic rat C-peptide 1 (100 ng/ml), during which (at 20 min) glucose concentration was switched from 2.7 to 16.6 mM. Insulin response to glucose (16.6 mM) was significantly decreased by the addition of the rat C-peptide 1 in advance when compared with those not pretreated with the C-peptide. In other experiments, the pancreas was exposed to glucose infusion (16.6 mM) for 60 min. 20 min after the start of glucose infusion, the C-peptide (100 ng/ml) was interposed for 20 min. The insulin secretion was reduced by the addition of the C-peptide. It is postulated that the C-peptide may have a role in the regulatory mechanism of the insulin secretion.

Animals↗