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Biomedical subjects

M Krukowski

Publications and source records attributed to M Krukowski.

28 records · Page 2Linked to original sources
PubMed1980

Normal osteoclast number and function in rat pups lacking parathyroid hormone.

In parathyroidectomized suckling rats, bone modeling and the number and activity of cells in the osteoclast population are normal. These findings are at variance with observations in older animals and suggest that factors other than parathyroid hormone influence osteoclast formation and function in the neonate.

Animals↗
PubMed1980

Intra-allantoic implantation: an alternative to the classical chorioallantoic membrane grafting technique.

A grafting method is described wherein donor tissue is partially inserted into a small slit cut into the proximal portion of the allantoic membrane of chick embryos aged 3.5-5.5 days. Cartilaginous bone rudiments handled in this manner readily vascularize, grow significantly, and begin osteogenesis within a 3-day incubation period. Compared to traditional chorioallantoic membrane grafting, usually done with hosts aged 9-12 days, the proposed intra-allantoic technique (1) greatly increased the period in which grafted materials are in residence (potentially up to 15 days) and (2) permits assessment of the host response of relatively young embryos.

Allantois↗
PubMed1976

pH and the level of calcium in the blood of fetal and neonatal albino rats.

Near-term rat fetuses in utero are acidotic and hypoxic, and have high levels of total serum calcium. In the first hour of postnatal life, pO2 and pH increase and pCO2 and calcium fall. Between 1 and 4 h following birth, respiratory gases vary little, whereas pH continues to rise and calcium further declines. By 4 h, newborns reach normal pH levels but are markedly hypocalcemic. It is suggested that the 'hypercalcemia' of intrauterine life is related to acidosis in utero, and that following birth, the initial fall in serum calcium is associated with the blowing off of CO2 and a concomitant rise in pH. The later decline in circulating calcium is independent of alterations in respiratory gases and relates directly to the final correction of neonatal acidosis.

Animals↗