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Biomedical subjects

M Krohn

Publications and source records attributed to M Krohn.

20 records · Page 2Linked to original sources
PubMedDate not supplied

Variation of HMGB1 expression in breast cancer.

The amount of steroid hormone receptor proteins does not always correlate with the response of breast cancers to endocrine therapy. This may partly be due to the fact that binding of the estrogen receptor (ER) to estrogen responsive elements (ERE) of its target genes is mediated by additional cellular proteins. One of these is the high mobility group protein HMGB1, known to interact with ER thus dramatically increasing its binding to ERE. This is the first report analysing the expression patterns of HMGB1 in breast cancer cells. Northern blot analyses of the 1.4 kb and the 2.4 kb transcripts of HMGB1 in 13 breast cancer samples revealed a strong intertumoural variation by a factor of 8.5 and 14.5, respectively. This variation may contribute to the different response, of estrogen receptor-positive breast tumours to endocrine therapy, making HMGB1 a marker of considerable clinical interest.

Adult↗
PubMedDate not supplied

[Diagnostic predictive value of C-reactive protein and expectant management of patients with premature rupture of the membranes].

To evaluate the predictive diagnostic value of CRP in a wait-and-see management of PROM 110 courses of labour and childbed with 114 babies were investigated with respect to both complications of mother and newborn. Complications during childbed could only be seen in 2.7%, 3.4% of the newborns suffered from septic disease. With regard to complications of newborns and mothers mediated by infection, CRP was demonstrated to have a prepartum sensitivity of 79% in combination with a specificity of 80%. The absolute highest sensitivity and specificity of CRP were found at a cut-off point of about 14 mg/l, which is clearly above the normal level of 6 mg/l serum. In almost 50% of the cases with maternal antepartum CRP levels up to 20 mg/l no pathogenic bacterial invasion could be revealed in the newborn. CRP therefore can be taken as an additional parameter in the management of PROM even in cases treated with corticosteroids due to its specificity and indicates better than WBC and polys when to terminate the wait-and-see attitude.

Adult↗