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Biomedical subjects

M Kraus

Publications and source records attributed to M Kraus.

186 records · Page 11Linked to original sources
PubMedDate not supplied

Conjunctivalization of Meibomian glands following cryosurgery for basal cell carcinoma of the eyelid.

Cryosurgery on the eyelids destroys the cellular elements in the frozen region, but preserves the collagenous supporting structures. Cells from the neighborhood colonize this framework during wound healing. The Authors describe a peculiar change in the Meibomian glands, which obviously developed by this mechanism in a lid treated by cryotherapy for a basal cell carcinoma. The collagenous lodges of the Meibomian glands, denuded of their sebaceous cells by the therapy, were epithelialized by ingrown conjunctival epithelium. This situation seems to promote the spread of and maintain acute and chronic exogenous inflammation in the tarsal plate.

Blepharitis↗
PubMedDate not supplied

Hepatopathy in 4 dogs treated with amiodarone.

Amiodarone is a class III antiarrhythmic drug used in dogs with dilated cardiomyopathy and ventricular tachyarrhythmias. Hepatopathy is one of the more commonly reported adverse effects of amiodarone use in people. We describe 4 dogs that developed hepatopathy associated with amiodarone administration; 2 dogs also developed neutropenia. Three dogs had clinical signs of anorexia and lethargy; 1 did not show signs until impaired liver function had developed. Clinical signs or biochemical abnormalities developed 1.5-8 months after amiodarone treatment was started. Clinical signs resolved within 2 weeks of discontinuing amiodarone, but biochemical abnormalities did not resolve for 6-8 weeks. The delay between onset of liver disease and overt clinical signs suggests that serial evaluation of liver enzyme activities following amiodarone use in does is important.

Amiodarone↗
PubMedDate not supplied

Relevance of microenvironmental pH for self-organized tumor growth and invasion.

The process of tumor cell growth, invasion and metastasis involves a self-organized cascade of multiple tumor-host and tumor-immune interactions. The prediction of cancer development based exclusively on molecular evidence is still impossible because of the complex and heterogeneous control mechanisms actually acting in cellular systems. In contrast, most tumor cell systems display a limited spectrum of macroscopically observable modes of action which emerge as a result of cellular self-organization. The stability of the dynamic modes is controlled by relatively few order parameters. Their number and characteristics are different in normal and neoplastic growth. A systems-oriented analysis utilizing our method of Structured Biological Modelling (SBM) suggests that microenvironmental pH (pHme) can function as an important order parameter for self-organized cancer development. In the scope of an integrated minimal model for the multistep development of invasive tumor growth, this finding will be discussed with respect to its evolution, diagnostic relevance and possible therapeutical implications. The study underlines the necessity of minimal invasive methods for the on-line in vitro and in vivo monitoring of pH, oxygen, signal transducing molecules and essential nutrients in the microenvironment of tumor cells.

Cell Division↗