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Biomedical subjects

M Kraus-Filarska

Publications and source records attributed to M Kraus-Filarska.

At least 37 records · Page 2Linked to original sources
PubMed1982

The behavior of T and B lymphocyte subpopulations in infectious and atopic bronchial asthma.

In 40 patients with infectious bronchial asthma and in 40 patients with atopic form of the disease, the behavior of T and B lymphocyte populations was studied by the E and EAC rosette tests. The control group consisted of 20 students unaffected by allergic diseases. A significant decrease in the percentage of E rosette forming T lymphocytes was found in the group of patients with atopic bronchial asthma, as compared with the control and infectious bronchial asthma groups (p less than 0.001). The proportions of EAC forming B lymphocytes showed no significant differences in all groups under examination.

Adolescent↗
PubMed1980

Effect of histamine on the spontaneous rosette formation.

Eight persons with clinically diagnosed hay fever were examined. The control group consisted of ten subjects without any signs of allergy. T lymphocyte subpopulation was evaluated by E rosette test. The effect of histamine was studied adding various concentrations of histamine (from 10(-9) to 10(-4) M) to the suspension of lymphocytes. A proportional drop in the percentage of the formed E rosettes could be seen at histamine concentrations ranging between 2 x 10(-9) and 2 x 10(-6) M. At 10(-6) up to 10(-4) M there was both an increase and further reduction in the percentage of the E rosette formation. A question arises whether there exists any correlation between the decreased number of T lymphocytes and elevated content of histamine in atopic persons?

Adult↗
PubMed1980

Effect of histamine on the spontaneous E rosette formation after blockade of histamine H2 receptors with cimetidine.

Thirteen patients with clinical diagnosis of hay fever, were examined. T lymphocytes subpopulation was determined by the E rosette test. The present study is concerned with the effect of histamine on the ability of T lymphocytes for E rosette formation after blockade of the histamine H2 receptor with its inhibitor cimetidine. It has been found that histamine effect is expressed by the histamine H2 receptor, as its blockade with cimetidine leads to the failure of histamine to inhibit rosette formation by T lymphocytes.

Adolescent↗
PubMed1980

T and B lymphocytes in patients with hay fever.

In 20 patients with hay fever and 19 control subjects the rosette formation test was carried out to determine T and B lymphocyte subpopulations. T and B lymphocyte subpopulations are expressed by the percentage of E, EA and EAC rosettes, respectively. Statistical analysis revealed a significant reduction in the number of E rosettes (p < 0.001), and a slight, but statistically significant decrease in the number of EAC rosettes (p < 0.05) in hay fever patients.

Adolescent↗
PubMed1980

Sorption of cholesterol and other bile components on ion-exchangers in vitro, and their influence on the cholesterol level in human serum in vivo.

The sorption of bile acids, bilirubin, bilirubin glucuronates and cholesterol on ion-exchange resin is described. After some successful attempts of sorption of these substances from human and animal bile in vitro, this exchanger has been used in human therapy. Positive results obtained showed the usefulness of the method. The purpose of the experiments was to study the usefulness of ion-exchangers for sorption of bile components of bile acids, bilirubin, bilirubin glucuronates and cholesterol. First sorption was carried out on human and animal bile, on Zerolit-FS-ip, in cycles (OH-) and (Cl-), by passing through glass columns downwards and some of them by mixing the bile with ion-exchange resin. Zerolit FS-ip is an organic sorbent, a scavenger, a strongly basic macroporous, anion exchanger. Positive results of these sorptions indicated the possibility of using this method in therapy of disturbed lipid conditions.

Adult↗
PubMedDate not supplied

Modulation of adhesion and chemotaxis of human neutrophils by cortisol, transforming growth factor-beta and antiinflammatory drugs.

Neutrophils are the first cells that accumulate in response to stimuli from the arising inflammation site. We have studied the influence of commonly used antiinflammatory (acetylsalicylic acid) and immunosuppressive (cyclosporin A, methotrexate) drugs and endogenous substances of antiinflammatory activity (cortisol, transforming growth factor-beta; TGF-beta) on the interdependent phenomena of cell motility and adhesion. Neutrophils from healthy subjects were preincubated with various concentrations of these substances and adhesion to plastic-bound monoclonal antibodies to CD11a/CD18, CD11c/ CD18 and CD44 was determined. We have found that the studied drugs significantly lowered adhesion (by 40%) of neutrophils to the ligands. Simultaneously, cell motility was investigated according to the Boyden method. We found a significant dose-dependent increase in the motility of this cells in a range comparable to conventional chemoattractants for neutrophils. These data indicate that simultaneous enhancement of motility and reduction of adhesion might be a common pathway for the mechanisms of action of the most common anti-inflammatory drugs.

Adult↗