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Biomedical subjects

M Krasnowska

Publications and source records attributed to M Krasnowska.

At least 19 recordsLinked to original sources
PubMed1995

[Bronchial reactivity after regular inhalation of salbutamol].

15 patients with mild bronchial asthma were selected for study. They inhaled salbutamol 2.5 mg three times daily for 8 days. Bronchodilator dose-response studies were performed by administering increasing doses of isuprel intravenously before and after treatment with salbutamol. Histamine provocation was done to estimate airway responsiveness. That was performed prior to and after salbutamol therapy. Regular inhaled salbutamol increased airway responsiveness to histamine--Pc20 was significantly reduced from 1.95 mg/ml--before treatment to 0.44 mg/ml--after salbutamol therapy. The bronchodilatory effect after isuprel was the same before and after treatment with salbutamol.

Administration, Inhalation↗
PubMed1994

[The effect of inhaling pirenzepine--selective M1 receptor antagonist and ipratropium bromide on lung ventilation in patients with bronchial asthma].

The study was carried out on 19 patients with moderate and severe bronchial asthma. During three days after the initial spirometric evaluation the patients received--on the first day 0.5 mg of pirenzepine in nebulization (P), on the second day 0.25 mg of ipratropium bromide (IB), on the third day both substances together. Ventilatory parameters were monitored on the 5th, 20th, 40th and 60th minute following nebulization. The observed parameters did not differ significantly between both groups. Pirenzepine given after ipratropium bromide increased FEV1 from 1.89 L to 2.37 L (p < 0.01). The observed results imply that pirenzepine given with ipratropium bromide induce a significant bronchodilating effect and could be added to therapy of bronchial asthma.

Administration, Inhalation↗
PubMed1994

[Bronchial hyperreactivity in patients with bronchial asthma treated with salbutamol and salbutamol combined with beclocort or nedocromil].

Salbutamol alone (400 micrograms per day) or salbutamol together with beclocort (1 mg per day) was used in 20 patients with mild asthma. 12 patients received during a month salbutamol combined with nedocromil (Tilade 8 mg per day). Prior starting treatment and after concluding a histamine provocation challenge was performed allowing to assess the bronchodilating properties of salbutamol. We conclude that: salbutamol alone produced a statistically nonsignificant increase of bronchial hyperactivity; a combination of salbutamol with beclocort or nedocromil did not increase the bronchial hyperactivity; during the three month trial with salbutamol alone or in a combination with a antiinflammatory agent the bronchodilatatory effect of salbutamol remained the same.

Adult↗
PubMed1992

[Effect of long term systemic steroid therapy on the cardiac muscle].

In asthmatic patients treated on a long term basis with steroids echocardiographic examination of the heart disclosed morphological and functional changes in the heart muscle. Such changes were not found in asthmatic treated occasionally with steroids. Differences between both groups depended on decreased contractibility of the heart muscle and concentric hypertrophy of the left ventricle present in asthmatic treated on a long term basis with systemic steroids.

Adrenal Cortex Hormones↗
PubMed1992

Inhaled natural human interferon alpha induces bronchospastic reactions in asthmatics.

There is a relationship between viral infection and aggravation of bronchial asthma symptoms. Viruses belong to the strongest and fast acting inducers of interferon (IFN), which, in turn, may enhance histamine release from effector cells. We have administered IFN intrabronchially to 49 patients suffering from bronchial asthma. The impairment of lung ventilation with significant decrease of forced expiratory volume in one second (FEV1) have been observed in majority of the patients who inhaled crude or purified IFN preparations.

Administration, Inhalation↗
PubMed1992

[Interferon as a bronchospastic factor in patients with bronchial asthma].

Twenty three asthmatics were examined during the symptoms free period. Each subject inhaled aerolised human interferon alpha (Hu IFN-alpha, Le) in increasing doses 4000 and 8000 units. IFN inhalation provoked significant decline in FEV1 (by 9.9% after the 1st dose and 6.6% after the 2nd dose on average). This results indicate that inhaled interferon induces bronchospastic reactions in asthmatics.

Adolescent↗
PubMed1990

[Acute myocardial infarction as a consequence of anaphylactic reaction after administration of urovision].

The case of 52-year old patient was presented who developed urticaria and strong anginal pain after intravenous administration of uropoline. On the basis of typical clinical picture, electrocardiographical and biochemical changes acute myocardial infarction was recognised. It is thought to have developed as the consequence of anaphylactic reaction following intravenous administration of x-rays contrast substance.

Anaphylaxis↗