Biomedical subjects

M Kotler

Publications and source records attributed to M Kotler.

185 records · Page 11Linked to original sources

PubMedDate not supplied

Traumatic war experiences affect outcome in a case of Tourette's syndrome.

BACKGROUND: Stress has been associated with the course of Tourette's syndrome (TS). METHODS: The case report presented aims to emphasize the effect a severe traumatic experience has on the expression of TS. RESULTS: Following an intense traumatic experience, combat-related, a relatively mild case of TS became intractable. CONCLUSION: The combination of both of these severe, sometimes refractory, disorders is rare, and poses a therapeutic challenge.

Adult↗

PubMedDate not supplied

Seizures and the Dandy-Walker syndrome: a case of suspected pseudoseizures.

BACKGROUND: A major pitfall in the diagnosis of conversion disorder is the difficulty in ruling out organic causes. METHODS. A 19-year-old female was referred with seizures and the Dandy-Walker syndrome. We continued the medical workup and also treated the patient with psychotherapy. RESULTS: The patient's symptoms gradually abated, however, the headaches remained. No neurologic illness evolved during the follow-up. CONCLUSIONS: The diagnosis of pseudoseizures is suggested according to clinical evaluation and follow-up. A multidisciplinary approach is recommended in such cases for efficient diagnosis and treatment.

Adult↗

PubMedDate not supplied

Vitamin B6 in treatment of tardive dyskinesia: a preliminary case series study.

Tardive dyskinesia (TD) remains a significant problem for patients and physicians. Several reports have suggested that vitamin B6 (pyridoxine) can be helpful in the treatment of some neuroleptic-induced movement disorders, including parkinsonism and TD. This report presents the results of a preliminary study of five patients with TD who underwent a four week open-label clinical trial of vitamin B6 (100 mg/d) in addition to their regular medications. The severity of the involuntary movements was assessed using the Abnormal Involuntary Movement Scale (AIMS), Barnes Akathisia Rating Scale (BARS) and the Simpson-Angus Scale (SAS). The patients' clinical status was assessed with the Brief Psychiatric Rating Scale (BPRS). With the addition of vitamin B6 to their treatment, four patients had clinically significant (greater than 30%) improvement on the measures of involuntary movement and, in three cases, there was also clinically significant improvement on the BPRS. None of the patients had side effects attributable to vitamin B6. The results suggest that vitamin B6 may alleviate TD, but it will need to be further tested in controlled double-blind trials.

Adult↗

PubMedDate not supplied

Delirium associated with vitamin B12 deficiency after pneumonia.

A case is presented of a 65-year-old man with chronic schizophrenia who, after four years of remission, developed psychotic symptoms after pneumonia. The patient was found to be deficient in vitamin B12. His psychosis remitted within 5 days of administration of vitamin B12 and folic acid. This case emphasizes the need to measure vitamin B12 in psychogeriatric patients, especially when they present with a severe infection and organic mental symptoms.

Aged↗

PubMedDate not supplied

Lamotrigine in the treatment of resistant bipolar disorder.

Antiepileptic drugs, such as carbamazepine and sodium valproate, are integral to psychopharmacologic therapy over the last decades. Lamotrigine is a new antiepileptic drug that acts on amino acid neurotransmitters/neuromodulators, most prominently, glutamine, which has been reported to have potential mood-stabilizing effects. The reports on this effect are limited and sparse, and systematic investigations have not been published. Here we present two clinical cases representing atypical patient groups in which lamotrigine was successfully used as an add-on therapy for resistant bipolar depression.

Adult↗