Biomedical subjects
Publications and source records attributed to M Kot.
The incidence of measles in New York City and Baltimore was studied using recently developed techniques in nonlinear dynamics. The data, monthly case reports for the years 1928-1963, suggest almost two dimensional, chaotic flows whose essential attributes are captured by one dimensional, unimodal maps. The effects of noise, inevitable in ecological and epidemiological systems are discussed.
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This report describes the case of an inflammatory pseudotumor of the liver in a 61 year-old female, diagnosed by an ultrasound scan (USG), computed tomography (CT) and needle biopsy. The right hemihepatectomy has been carried out. There were no complications in the post-operative course.
The results of the complex treatment of 125 patients with unilateral and bilateral lip and palate cleft, aged 3-5, 10-12 and 14-18 years, were evaluated by analysis of medical documentation. The study showed that the results of lip, vestibule and palate reconstruction and speech can be evaluated already at 12 years of age. However, final esthetic and functional assessment of the nose and maxillo-occlusional conditions is indicated after 14 years of age, best between 18-20 years.
The study concerned 230 patients (175 UCLP and 55 BCLP) aged 14-20, who had been treated in the years 1972-82 in accordance with the Centre for Congenital Defects programme, at the Department of Plastic Surgery, Medical University of Lódź. The follow-up comprised: aesthetic and functional assessment of the lip, upper vestibule and nose as well as evaluation of occlusion and speech abilities (intelligibility, articulation, nasality). The assessment of lip and vestibule gave good and acceptable results in 97% of UCLP patients and in 89% of BCLP. The external nose appeared aesthetically and functionally good in 67% of UCLP and in 94% of BCLP. The defects of occlusion, mainly various forms of cross-bite, were found in 48% of UCLP, who had undergone orthodontic treatment. The maxillo-occlusal defects with no prior orthodontics were found in 63% of UCLP. Alike the defects of occlusion in untreated BCLP were most frequent. The intelligibility and articulation of speech were significantly better in patients who had undertaken the postoperational speech therapy (95%:75%). The assessment in general presented better results in UCLP patients, who had been submitted not only to surgery but also took up orthodontic treatment and speech therapy.
The primary metabolic pathways of caffeine are 3-N-demethylation to paraxanthine (CYP1A2), 1-N-demethylation to theobromine and 7-N-demethylation to theophylline (CYP1A2 and other enzymes), and 8-hydroxylation to 1,3,7-trimethyluric acid (CYP3A). The aim of the present study was to investigate the influence of phenothiazine neuroleptics (chlorpromazine, levomepromazine, thioridazine, perazine) on cytochrome P-450 activity measured by caffeine oxidation in rat liver microsomes. The obtained results showed that all the investigated neuroleptics competitively inhibited caffeine oxidation in the rat liver, though their potency to inhibit particular metabolic pathways was not equal. Levomepromazine exerted the most potent inhibitory effect on caffeine oxidation pathways, the effect on 8-hydroxylation being the most pronounced. This indicates inhibition of CYP 1 A2 (inhibition of 3-N- and 1-N-demethylation; Ki = 36 and 32 microM, respectively), CYP3A2 (inhibition of 8-hydroxylations; Ki = 20 microM), and possibly other CYP isoenzymes (inhibition of 7-N-demethylation; Ki = 58 microM) by the neuroleptics. The potency of inhibition of caffeine oxidation by perazine was similar to levomepromazine. Thioridazine was a weaker inhibitor of caffeine 3-N- and 7-N-demethylation, while chlorpromazine was weaker in inhibiting caffeine 1-N- and 7-N-demethylation, compared to levomepromazine. In summary, the obtained results showed that all the investigated neuroleptics had a broad spectra of CYP inhibition in the rat liver. The isoenzymes CYP1A2 and CYP3A2 were distinctly inhibited by all the investigated neuroleptics, while other CYP isoenzymes (CYP2B and/or 2E1) by perazine and levomepromazine. The CYP3A2 inhibition was most pronounced. (Ki = 20-40 microM).
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