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Biomedical subjects

M Korsić

Publications and source records attributed to M Korsić.

At least 37 records · Page 2Linked to original sources
PubMed1991

Effects of (DesGly9-Arg8) vasopressin on cognitive processes in alcoholic patients.

The effect of intranasally administered (DesGly9-Arg8) vasopressin (DGAVP) on certain aspects of cognitive functions of alcoholic patients was studied. The investigation was carried out in 103 chronic alcoholic patients. None of the patients suffered from Korsakoff's syndrome, portal encephalopathy or brain damage of other etiology. The trial was double-blind, placebo controlled. Psychological testing, which included certain aspects of attention, short-term and long-term memory and spatial orientation, was carried out on the day before (baseline measurements), on the last day (II), and seven days after the last administration of DGAVP (III). No treatment effect of DGAVP was observed. The results show that investigations with humans are infinitely more complex than those with animals, since a number of physiological and socio-psychological factors must be controlled. In this study of alcoholics two such factors: 1) duration of abstinence and 2) adaptation to test situation were identified.

Adult↗
PubMed1990

Some aspects of adrenocortical stress response following stroke.

Stress response measured as the cortisol secretion rate as well as urinary 17 oxogenic steroid (17 OGS) and 17 oxosteroid (17 OS) excretion was investigated in a group of 28 patients with stroke (11 with hypertensive intracerebral hemorrhage and 17 with ischemic cerebrovascular insult). Significantly higher cortisol secretion values were found in the group of patients who died (p less than 0.01). Similarly, the first day urinary 17 OGS excretion pointed to the greater adrenocortical response in patients who died (p less than 0.05). Urinary 17 OS excretion was normal or below normal in the majority of patients and no difference was found between either male or female patients who survived or died. Our findings indicate that adrenocortical changes which maximize the production of cortisol are operative soon after the onset of stroke. The cortisol secretion rate appeared to be a good indicator of the severity of the stress caused by stroke and may be useful in predicting the prognosis of the illness.

17-Hydroxycorticosteroids↗
PubMed1989

[Corrected Q-T interval in the electrocardiogram in patients with anorexia nervosa].

This paper examined the corrected Q-T interval in a group of 15 patients with anorexia nervosa and in 30 patients of a control group. Prolonged corrected Q-T interval was found in 2 of 15 patients with anorexia nervosa (13%) and in one of 30 patients of a control group (3%). The correlation between corrected Q-T interval and body mass index in patients with anorexia nervosa was not found (r = +0.13). Relative risk for prolonged corrected Q-T interval in patients with anorexia nervosa was high (4.5) compared with a control group. It is well known that prolonged corrected Q-T interval is connected with a high risk for sudden death because of a malignant ventricular arrhythmias.

Adolescent↗
PubMed1984

Infarction of FSH-secreting pituitary adenoma.

A patient with an FSH-producing adenoma is reported. Two hours after LRH administration (100 microgram iv) the clinical signs of tumour infarction developed. The patient followed a severe clinical course. FSH levels normalised but further deterioration of pituitary function was documented. Worsening of the vision without improvement after surgical resection of the adenoma was observed. The role of LRH testing in adenoma infarction is discussed.

Adenoma↗
PubMed1977

The effect of alternate-day prednisone therapy on cortisol secretion rate in corticosteroid-dependent asthmatics.

The effect of alternate-day prednisone regimen (nine-patients) on cortisol secretion rate was compared with daily therapeutic regimen (ten patients) in corticosteroid-dependent asthmatics. Only the alternate-day regimen did not suppress the adrenal function. The therapeutic efficacy of both regimens was equal. The advantages of alternate-day corticosteroid therapy are presented and the optimal way of starting this therapy discussed.

Adrenal Cortex Hormones↗
PubMed1977

Cortisol secretion rate during beclomethasone dipropionate aerosol therapy in bronchial asthma.

Beclomethasone dipropionate is a new synthetic corticosteroid for the inhalatory treatment of bronchial asthma. The effect of beclomethasone dipropionate aerosol (400 mug/day/j weeks) on the cortisol secretion rate in comparison with prednisone per os (10 mg/day/4 weeks) was investigated in 12 patients with allergic bronchial asthma. There was no suppression of the adrenal cortex in the course of beclomethasone dipropionate inhalation, while prednisone significantly suppressed adrenal cortex function.

Adrenal Cortex↗
PubMedDate not supplied

Glycosylated haemoglobin in clarification of the origin of hyperglycaemia in acute cerebrovascular accident.

In 148 patients admitted to hospital with acute cerebrovascular accidents (CVA), the levels of glycosylated haemoglobin (HbA1c) and blood glucose were measured to evaluate the effect of the duration and severity of hyperglycaemia on stroke outcome. Eighty-eight (59%) patients had clearly normal blood glucose and HbA1c concentrations (blood glucose less than 5.5 mmol l-1, HbA1c less than 8.6%). The remaining 60 patients were defined as hyperglycaemic. Nineteen (13%) had known diabetes, whereas in 23 (16%) hyperglycaemia was probably due to unrecognized diabetes. In 18 (12%) patients transient hyperglycaemia was observed. Recovery after CVA was best among normoglycaemic patients (good 45%, moderate 29%, poor 14%, fatal 12%) and poorest among diabetic patients (moderate 21%, poor 37%, fatal 42%). Fatal outcome in patients from the normoglycaemic group differed significantly from patients belonging to known diabetic and unrecognized diabetic groups (p less than 0.05), but was not different from that in patients with transient hyperglycaemia, who did however differ from both diagnosed and unrecognized diabetic patients (p less than 0.05). No significant differences were found between CVA outcome in the known diabetic and unrecognized diabetic groups.

Adult↗
PubMedDate not supplied

[Low-renin hypertension and inherited mineralocorticoid diseases].

Liddle's syndrome, apparent mineralocorticoid excess (AME) and glucocorticoid remediable aldosteronism (GRA) are inherited diseases characterized by hypertension and low plasma renin activity. Constitutive activation of distal renal epithelial sodium channel (Liddle's syndrome), defect in 11 beta-hydroxysteroid dehydrogenase activity (AME) and unequal crossing over, fusing regulatory sequences of 11 beta-hydroxylase gene to coding sequences of aldosterone synthase gene and forming a new chimeric gene (GRA), cause apparent or real mineralocorticoid excess. This diseases are often being unrecognized and classified as essential hypertension, especially in patients with normal serum potassium level. Family history of hypertension and characteristic serum and urine++ steroid profile direct us to diagnosis, and genetic analysis will confirm it.

Humans↗
PubMedDate not supplied

[Importance of the CRH (corticotropin releasing hormone) test in the differential diagnosis of Cushing's syndrome].

In the group of 13 patients with Cushing's syndrome (CS) CRH test was performed by sampling the blood from peripheral vein and in eight patients also after inferior petrosal sinus catheterization (IPSC) to resolve the disease etiology. In the group of patients with Cushing's disease (CD, n = 11), which was proven by surgery and adenoma immunohistochemistry, 10/11 had in CRH test the significant increase of cortisol and ACTH in the peripheral blood. Among two patients with ectopic ACTH syndrome one had the significant increase of both hormones in CRH test. After IPSC the ratio of ACTH in the petrosal sinus and in the peripheral vein was significant in 4/8 patients before, and in 6/8 after CRH administration. The intersinus gradient was significant in 3/8 patients before, and in 4/8 after CRH test. According to our results we can conclude that the determination of ACTH in the blood from peripheral veins after CRH administration is a very sensitive method for differential diagnosis of CS, while the results after IPSC were less sensitive in our conditions than those described in the literature.

ACTH Syndrome, Ectopic↗
PubMedDate not supplied

[Tonometry in the diagnosis of subclinical ophthalmopathy in patients with Basedow's disease].

Ophthalmopathy in addition to hyperthyreosis with goitre and dermopathy is characteristic of Basedow's exophthalmos is frequently associated with elevated intraocular pressure (IOP) on upgaze. We wanted to examine whether these changes of IOP exist in patients with Basedow's disease without clinical manifestations of ophthalmopathy. We measured IOP with Goldmann's applanation tonometry in two positions: the primary position, when the patient looks straight ahead and then on upgaze. Forty-six patients with Basedow's disease were examined. The minority [5 (11%)] of the 46 patients had exophthalmos and 22 (47%) of them had abnormal IOP (delta IOP greater than or equal to 3 mmHg). The average interval between the onset of Basedow's disease and this study was 12.8 +/- 7.4 years for those patients who had exaggerated positional changes in IOP, as compared with 5.8 +/- 3.3 years for those with normal IOP, P less than 0.01. We conclude that Basedow's ophthalmopathy is more common than is recognized clinically and that ophthalmopathy is more frequent in patients suffering of Basedow's disease for a longer period. Measuring IOP in two positions is a very simple method which could help us in early diagnosis of ophthalmopathy in patients with Basedow's disease.

Adult↗