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M Kornitzer

Publications and source records attributed to M Kornitzer.

At least 37 records · Page 2Linked to original sources
PubMed1999

Parental history of premature coronary heart disease mortality and signs of ischemia on the resting electrocardiogram.

OBJECTIVES: Here we explore the association between a family history of premature coronary heart disease (CHD) death and ischemic electrocardiogram (ECG) findings in the offspring. BACKGROUND: In the general population, signs of ischemia are found on the resting ECG in about 10% of middle-aged men and women. Their independent predictive value for CHD morbidity and mortality has been shown in several studies. METHODS: Our results are based on cross-sectional data from three large epidemiological studies performed in Belgium during the past two decades: the Belgian Heart Disease Prevention Project (n = 8,145), the Belgian Interuniversity Research on Nutrition and Health survey (n = 7,625) and the MONICA project (n = 3,193). A parental history of fatal CHD was considered premature if the father died from CHD before age 60 or the mother before age 70. Ischemic ECG findings were defined according to Minnesota Code criteria I(1-3), IV(1-3), V(1-3) or VII1. RESULTS: Subjects with a parental history of premature CHD death were found to have experienced significantly more frequently symptomatic CHD. After exclusion of symptomatic individuals, no major differences in lifestyle-related risk factors were found between the groups with and without a parental history of premature fatal CHD. After multivariate adjustment for age, smoking, body mass index and sex, the odds ratios (and 95% confidence interval [CI]) for ECG ischemia associated with a positive parental history of premature death were 1.42 (1.10-1.82), 1.47 (1.16-1.88) and 1.37 (0.78-2.41) in the three studies. Additional adjustment for systolic blood pressure, total cholesterol and, if available, lifestyle-related factors did not alter the magnitude of the odds ratios. Overall, in men aged 45 to 64 years, ECG ischemia was significantly more frequent (36% excess) in those with positive parental history. CONCLUSIONS: Subjects in whom one or both parents died prematurely from cardiac-related diseases have signs of ischemia more frequently on their electrocardiogram, and this is independent of other risk factors.

Adult↗
PubMed1999

Trends in coronary heart disease in two Belgian areas: results from the MONICA Ghent-Charleroi Study.

SETTING: As part of the WHO-MONICA study, acute coronary events have been registered from 1983 until 1992 in the general population aged 25-69 years in two Belgian cities--Ghent in the northern Dutch speaking part of Belgium and Charleroi in the southern French speaking part. Registration of events was done according to an international standard protocol. OBJECTIVE: To study trends in total, fatal and non-fatal event rates and trends in case fatality rates in these two cities. MAIN RESULTS: Incidence of CHD was on average 50% higher in Charleroi compared with Ghent in both men and women (attack rate ratio Charleroi/Ghent was 1.5 in both sexes). In both men and women, diverging trends were observed between the two cities for total and non-fatal event rates, while parallel declining trends were observed in fatal event rates and in case fatality rates. In both sexes, total attack rates showed a significant decrease in Ghent and a significant increase in Charleroi. Also in the two sexes, attack rates of non-fatal events increased significantly in Charleroi and remained stable in Ghent. Attack rates of fatal events decreased significantly in men and women in Ghent and in men in Charleroi. Both "total" and "in hospital" case fatality rates declined significantly in both sexes in the two cities. CONCLUSIONS: Important differences in coronary heart disease (CHD) incidence and CHD trends between Ghent and Charleroi were observed. These differences and trends are interpreted in the context of existing and still growing differences in the overall socioeconomic situation between the north and the south of the country. On the other hand, the efficacy of medical treatment of CHD is comparable in the two regions, as reflected by similar figures and trends for case fatality rates.

Adult↗
PubMed1999

Epidemiology of risk factors for hypertension: implications for prevention and therapy.

We review the present knowledge of risk factors for arterial hypertension. Both genetic and environmental factors as well as their interaction and biological plausibility are reviewed. Recent data confirm that the interaction of genetics with multiple environmental risk factors explains the high prevalence of hypertension in the industrialised countries. The most important modifiable environmental risk factors are high salt intake, alcohol intake, obesity and low physical activity. The role of stress in the aetiology of high blood pressure is still under investigation, but recent clinical experimental and epidemiological data have shed light on how stress could be related to hypertension. The implications for prevention and treatment are discussed both at the population and individual levels. The population approach involves a public health policy aiming at modification of the major risk factors. The individual approach involves nonpharmacological measures to prevent the development of hypertension and to treat high normal blood pressure and mild hypertension with no additional cardiovascular risk factors. Pharmacological treatment of hypertension in most individuals should use agents that have been proven to be effective in randomised controlled trials with 'hard' endpoints such as cardiovascular and cerebrovascular morbidity and mortality.

Female↗
PubMed1999

[The decision to treat based on epidemiological methodology: the paradigm of hypercholesterolemia].

The author reviews the epidemiological methods, both non experimental and experimental, founding evidence-based medicine. As an example, he reviews the evolution of the scientific knowledge about the relationship between hypercholesterolemia and coronary heart disease and about the determinants of the serum cholesterol concentration. Epidemiology studies the causal chain between exposure and event (sickness) and proposes, within the framework of primary and secondary prevention of coronary heart disease, interventions to interrupt the causal chain at a given level.

Causality↗
PubMed1998

Epidemiological aspects of high density lipoprotein cholesterol.

Most of the results from epidemiologic studies support the general idea that high density lipoproteins (HDL) cholesterol is inversely related to coronary heart disease (CHD) incidence. Results from the literature and from a large cohort study in Belgium (the BIRNH study) are used to describe the distribution and the major determinants of HDL cholesterol. HDL cholesterol is influenced by a variety of biologic, environmental and behavioral characteristics. Results of a 10-year mortality follow-up of the BIRNH study are presented and compared to those observed in other large cohort studies. The inverse relationship between HDL cholesterol and CHD is confirmed, although the strength of the association varies between studies and is weakened after adjustment for other coronary risk factors. The results from the BIRNH study also suggest that the relation between HDL cholesterol and CVD mortality is curvilinear. At present, only indirect evidence is available to support the idea that raising HDL cholesterol is useful in primary and secondary prevention of CHD.

Cholesterol, HDL↗
PubMed1998

Prognostic value of ischemic electrocardiographic findings for cardiovascular mortality in men and women.

OBJECTIVES: The aim of this study was to investigate the independent prognostic value of ischemic electrocardiographic (ECG) findings for cardiovascular mortality and to evaluate a possible sex-differential in this regard. BACKGROUND: In previous reports, ST segment and T wave changes on the resting ECG were described as independent risk factors for development of coronary heart disease. Although more prevalent in women, they are often given less clinical importance than in men. METHODS: Ten-year follow-up data from the Belgian Interuniversity Research on Nutrition and Health study were used. The results presented here are based on ECGs of the 4,797 men and 4,320 women, aged 25 to 74 years, who were free of angina pectoris at the start of follow-up, had no history of myocardial infarction (MI) and showed no Q wave evidence of an old MI on their ECG. RESULTS: At baseline, the age-standardized prevalence of an "ischemic ECG" (Minnesota codes I3, IV1-3, V1-3 or VII1) was 8.4% in men and 10.6% in women. Cardiovascular mortality rates in men and women with an ischemic ECG were respectively 7.7 and 2.6 per 1,000 person-years, compared with 2.3 and 1.0 in those with no such ECG findings. After correction for the potential confounding effects of established cardiovascular disease (CVD) risk factors, the multivariately adjusted risk ratios were 2.45 (95% confidence interval [CI]: 1.70 to 3.53) for men and 2.16 (95% CI: 1.30 to 3.58) for women. Testing the interaction between an ischemic ECG and sex on CVD mortality revealed that the risk ratios were not significantly changed (p=0.95). The etiologic fraction of CVD deaths attributable to an ischemic ECG was estimated as 19.3% for men and 22.4% for women. Both men and women with major ischemic findings in their baseline electrocardiogram (Minnesota codes IV1,2, V1,2 or VII1) had a fourfold increased risk of CVD death. CONCLUSION: These results support the hypothesis that women with ischemic ECG findings are at the same increased risk for CVD mortality as men.

Adult↗
PubMed1998

Prevalence, awareness, treatment and control of arterial hypertension in an elderly population in Belgium.

OBJECTIVE: To study the prevalence, awareness, treatment and control of arterial hypertension in the elderly population in Belgium. STUDY GROUP: An age- and sex-stratified sample of 2212 Belgian subjects aged 65 years or more, selected from the original cohort of the Belgian Interuniversity Research on Nutrition and Health (BIRNH) study; participation in this follow-up study was 72.6%. METHODS: Blood pressure (BP) was measured at home by trained technicians using a standard protocol. Isolated systolic hypertension (ISH) was defined as a systolic BP > or =160 mm Hg and a diastolic BP <95 mm Hg. Diastolic hypertension was defined as a diastolic BP > or =95 mm Hg. The total hypertensive population was defined as all those with ISH, diastolic hypertension and with BPs <160-95 mm Hg but currently taking antihypertensive drugs. Awareness and treatment status were investigated through a structured interview. RESULTS: The prevalence of arterial hypertension was 43.9%, higher in women than in men and increasing with age in women; elevated BP was found in 22.3 to 28.6% of the participants varying by age and sex. In the >75-year-old subjects this elevation was in two-thirds of the cases due to ISH; 84% of all female hypertensives were aware of the condition compared to 68% in men. Treatment advice had been given in a majority of the aware subjects and two-thirds of all treated persons was under control. Among a variety of independent variables and besides the gender difference, awareness was only related to smoking and to depression while control differed by region of residence. CONCLUSION: Arterial hypertension is highly prevalent in this elderly population; awareness and BP control are within acceptable ranges but there is still room for improvement, particularly in elderly men.

Age Distribution↗
PubMed1998

Hormone and nonhormone therapy for the maintenance of postmenopausal health: the need for randomized controlled trials of estrogen and raloxifene.

Multiple health benefits have been postulated for the long-term use of hormone therapy in postmenopausal women, most notably for prevention of osteoporotic fractures and coronary heart disease, as well as several risks, including cancer of the breast and uterus and venous thromboembolism. Cardiovascular disease is the most common cause of death among postmenopausal women. If real, the reduction in risk of coronary heart disease by hormone use suggested by observational studies would likely outweigh the risks. The decision to initiate and maintain hormone therapy is complicated by uncertainties about estrogen's true benefits and risks. Raloxifene, a selective estrogen receptor modulator (SERM), appears to have many of the benefits of estrogen without the cancer risks. It is not known if SERMs can provide significant cardiovascular protection. This article reviews the relation of use of postmenopausal hormones and raloxifene to women's health and addresses the need for large randomized trials to quantify the effect of both postmenopausal estrogen and raloxifene on cardiovascular health.

Cardiovascular Diseases↗
PubMed1998

Trends in the prevalence, detection, treatment and control of arterial hypertension in the Belgian adult population.

OBJECTIVES: To discuss changes during the past decades in the prevalence and in the patterns of detection, treatment and control of arterial hypertension in the general Belgian population aged 25-64 years. DESIGN: Data from two cross-sectional cardiovascular disease risk factor surveys of the general population aged 25-64 years during the first and second halves of the 1980s (the Belgian Inter-university Research on Nutrition and Health study of 1980-1984 and the World Health Organization Multinational Monitoring of Trends and Determinants in Cardiovascular Diseases study of 1985-1992) are compared. PARTICIPANTS: Age-stratified and sex-stratified random samples from the general population yielded 9372 participants in the former study and 4904 participants in the latter. METHODS: In both studies, blood pressure measurements and other variables were collected in the same standardized way and by the same observers. RESULTS: For both sexes, overall age-standardized prevalences of hypertension (subjects with systolic blood pressure > or = 160 mmHg or diastolic blood pressure > or = 95 mmHg or currently being administered antihypertensive drug treatment) were found to be significantly (P< 0.001) higher in the former than they were in the latter study. A significant decline in population mean systolic blood pressure values was observed for both sexes on going from the former data to the latter (falls of 6.0 and 7.3 mmHg for men and women, respectively, P< 0.01). In log-linear models, adjusted for age, a highly significant (P< 0.0001) favourable shift in the population distribution over the various categories of detection, treatment and control of hypertension was observed. This trend exhibited a significant sex difference, however, there being a much more favourable trend for women. CONCLUSIONS: In Belgium, favourable trends in the prevalence and in the patterns of detection, treatment and control of arterial hypertension and in the levels of systolic blood pressure were observed. The so-called 'rule of halves' is no longer valid.

Adult↗
PubMed1998

Primary and secondary prevention of coronary artery disease: a follow-up on clinical controlled trials.

Most probably the decennia of the 1990s will be called the 'statin decennia' in the history of coronary heart disease prevention. Statins are effective, both in primary and secondary prevention of coronary heart disease, in middle-aged and older (< 76 years) men and women, in both diabetics and non-diabetics with coronary heart disease. Statins used in secondary prevention of coronary heart disease significantly reduce the risk of stroke. They also reduce daily attacks of myocardial ischemia. Pathogenetic pathways leading to 'biological plausibilities' of the statins favourable effects are multiple, which explains their rapid (less than 1 year) influence on coronary events. Until the results from new event trials become available, fibrates have very few indications as first line drug therapy in dyslipidemia. They should be considered in combined therapy with statins. The scientific evidence with statins is overwhelming and the question is no longer 'who should we treat?' but 'who can society afford to treat?'. Health economics are indeed pivotal in the use of statins and public health authorities have to find answers according to their resources or innovative strategies, including new aspects in dietary advice (the 'Mediterranean diet'?).

Adult↗
PubMed1998

Prognostic value of ECG findings for total, cardiovascular disease, and coronary heart disease death in men and women.

OBJECTIVE: To study abnormalities in the resting ECG as independent predictors for all cause, cardiovascular disease (CVD), and coronary heart disease (CHD) mortality in a population based random sample of men and women, and to explore whether their prognostic value is different between sexes. DESIGN AND SUBJECTS: An age and sex stratified random sample was selected from the total Belgian population aged 25 to 74 years. Baseline data were gathered and resting ECGs were classified according to Minnesota code criteria. The sample was then followed for at least 10 years with respect to cause specific death. Results are based on observations from 5208 men and 4746 women free from prevalent CHD at the start of the follow up period. RESULTS: Although the prevalence of major abnormalities in general was comparable between sexes, women had more ischaemic findings, ST segment changes, and abnormal T waves on their baseline ECG, while men showed more arrhythmias, bundle branch blocks, and left ventricular hypertrophy. Fitting the multiplicative effect on subsequent mortality between all ECG classifications under study and sex indicated that the prognostic value of ECG changes was equal in women and men. Independently of other risk factors and other major ECG changes, almost all ECG classifications were significantly related to all cause, CVD, and CHD mortality. The most predictive ECG findings for CVD death were ST segment depression (risk ratio (RR) 4.71), major ECG findings (RR 3.26), left ventricular hypertrophy (RR 2.79), bundle branch blocks (RR 2.58), T wave flattening (RR 2.47), ischaemic ECG findings (RR 2.35), and arrhythmias (RR 2.15). The prognostic value of major ECG findings for CVD and CHD death was more powerful than well established cardiovascular risk factors. CONCLUSIONS: Abnormalities in the baseline ECG are strongly associated with subsequent all cause, CVD, and CHD mortality. Their predictive value was similar for men and women.

Adult↗
PubMed1998

Misclassification of coronary heart disease in mortality statistics. Evidence from the WHO-MONICA Ghent-Charleroi Study in Belgium.

STUDY OBJECTIVE: To validate the Belgian vital statistics for coronary heart disease (CHD) on the basis of an independent acute myocardial infarction (AMI) register, carried out as part of the WHO-MONICA project. DESIGN: Records of fatal cases of AMI in the WHO-MONICA register were individually linked to the corresponding death certificates. SETTING: Since 1983, the WHO-MONICA Collaborating Centre Ghent/Charleroi registers all fatal and non-fatal AMI in the age group 25-69 years in two geographical areas, Ghent in the northern Dutch speaking part and Charleroi in the southern French speaking part of Belgium. Registration is done according to the MONICA protocol. The official vital statistics in Belgium are published on a yearly basis. They are essentially a reflection of the "underlying" causes of death, coded according to the 9th revision of the International Classification of Diseases (ICD). The study was undertaken in the period 1983-1991. MAIN RESULTS: Out of a total of 741 (Ghent) and 934 (Charleroi) well documented MONICA fatal cases of AMI, 492 (66.4%) and 641 (68.6%), respectively, were officially labelled as CHD (ICD code 410-414); 438 (59.1%) and 385 (41.2%), respectively, were officially labelled as AMI (ICD code 410). A substantial fraction of the MONICA AMI cases--27.1% in Ghent and 38.2% in Charleroi--was coded as "other forms of CHD" (ICD 411-414) or as "other forms of heart disease" (ICD 420-429). The remaining MONICA AMI cases--13.8% in Ghent and 20.6% in Charleroi--were classified in either very aspecific (for example, atherosclerosis, ICD 440) or totally unrelated ICD codes (for example, neoplasm, ICD 140-239). CONCLUSIONS: It is concluded from the results in this paper that a substantial part of all deaths caused by CHD in Belgium are labelled with incorrect ICD codes and are therefore misclassified in the official mortality statistics for Belgium. This is partly caused by a "drainage" of cases towards less specific CHD related ICD categories. A considerable fraction, however, seems to be absolutely misclassified.

Adult↗
PubMed1998

Is low serum chloride level a risk factor for cardiovascular mortality?

BACKGROUND: Serum chloride level is routinely assayed in clinical laboratories in the management of patients with kidney disorders and with metabolic diseases. It is a biological parameter that is easily, precisely and relatively cheaply measured. The epidemiological features of serum chloride levels have not been studied before. METHODS: For the random sample of men and women from the Belgian Interuniversity Research on Nutrition and Health aged 25-74 years, free of symptomatic coronary heart disease at baseline, serum chloride concentrations were measured, among those of other electrolytes. The cohort was followed up for 10 years with respect to subsequent cause-specific mortality. RESULTS: The results are based on observations of 4793 men and 4313 women. According to Cox regression analysis serum chloride level was one of the strongest predictors of total, cardiovascular disease (CVD) and non-CVD mortalities independently of age, body mass index, sex, smoking, systolic blood pressure, levels of total and high-density lipoprotein cholesterol, uric acid, serum creatinine and serum total proteins and intake of diuretics. This relation was proved to be independent of levels of other serum electrolytes and similar for men and women. The estimated adjusted risk ratio for CVD death for subjects with a serum chloride level < or =100 mmol/l compared with those with levels above that limit was 1.65 (95% confidence interval 1.06-2.57) for men and 2.16 (95% confidence interval 1.11-4.22) for women. The study of adjusted risk ratios for four groups of subjects defined on the basis of their baseline serum chloride levels revealed a decreasing log-linear 'dose-response' relation to total and cardiovascular mortalities. CONCLUSION: This s the first report from a population-based study to indicate that there is an association between serum chloride level and the incidence of total, CVD and non-CVD mortalities. The risk ratio for CVD mortality associated with a low serum chloride level was comparable to or higher than those observed for well-established CVD risk factors.

Adult↗
PubMed1997

[Hypercholesterolemia in Belgium in 1996: an epidemiological viewpoint].

The authors review the epidemiological evidence linking causally the level of blood cholesterol to coronary heart disease. The evidence is based both on analytical and experimental epidemiology. They review also the two strategies of prevention: the strategy of screening for the detection of "high risk" subjects and the "population" or mass approach. The distribution of blood cholesterol in Belgium according to the Belgian Interuniversity Research on Nutrition and Health (BIRNH) data is presented. Finally, blood cholesterol is placed within a multifactorial prevention perspective using the Framingham equations. The multifactorial approach is now based on different instruments among which the graphs published by the European Society of Cardiology which are "user friendly".

Adult↗
PubMed1996

[20 years of cardiovascular epidemiology. The epidemiologist's viewpoint].

The author reviews the evolution of cardiovascular epidemiology during the twenty last years. The mortality from cardiovascular diseases with atherosclerosis as their pathological basis grew rapidly in the industrialised countries after World War II. This led to epidemiological research which started in 1950 with respectively the studies of Framingham in the United States and the Seven Countries Study, essentially in Europe. The concept of multifactorial origin of coronary heart disease was proposed during the 60s. Three major coronary risk factors besides age and gender, hypercholesterolemia, hypertension and cigarette smoking emerged systematically in epidemiological studies before 1975. The last twenty years have confirmed the importance of these three modifiable coronary risk factors which are long-term predictors in different ethnic groups, both in males and females. Other risk factors appeared in this period. Some polymorphisms of several genes as well as their phenotypic expression have been found to be related to an increased risk of coronary heart disease. Uni- and multifactorial primary and secondary prevention trials have confirmed the observations of analytical epidemiology. Moreover, the crucial role of nutrition within a metabolic hypothesis has been confirmed by experimental research. The concept of the strategy of prevention in higher risk subjects as well as in the whole population was proposed by international bodies following the publications by the English epidemiologist G. Rose. Both France and Belgium contributed to the development of cardiovascular epidemiology during the last twenty years. France is doing cutting-edge research on genetic predictors of cardiovascular diseases. Although the multifactorial causal model of cardiovascular diseases is robust, it is still a probabilistic one; it predicts however relative risks of about 15 to 1 according to the decile of the multilogistic function distribution. Environmental factors essentially related to lifestyles explain a great part of these differences. At the individual level, genetic factors most probably modulate these environmental influences and one can foresee in the future a more predictive model. In most medical schools, teaching of cardiovascular epidemiology and prevention has a low priority with clinicians putting the accent on the risk factors rather than on the risk profile of the individual. Secondary prevention is more in the realm of clinical medicine due to a large publicity given to the results of the large randomised trials. Consequently, in hospital mortality of acute myocardial infarction is decreasing as well as long-term mortality. Finally, prevention at the population level is connected to political decisions in public health which could have a major impact on the economy at the country level. Consequently, these political decisions are very slow to be taken both at the national and European Union level.

Cardiovascular Diseases↗
PubMed1995

Combined use of nicotine patch and gum in smoking cessation: a placebo-controlled clinical trial.

BACKGROUND: Smoking is considered as an addiction to nicotine for most subjects consuming 10 cigarettes or more per day. Hence, nicotine replacement therapy by way of gum, patch, or spray has been advocated. The rationale of this study is to evaluate the possible beneficial effects of adding nicotine gum to the routine of subjects using the nicotine patch. The effect of the nicotine patch against the placebo, both groups receiving placebo nicotine gum, has also been assessed. METHODS: Healthy subjects (374) were randomized at their work-setting in a 1-year double-blind placebo-controlled trial: 149 subjects to active nicotine patch + active gum (group 1), 150 to active nicotine patch + placebo gum (group 2), and 75 to placebo patch + gum (group 3). Treatment duration was 12 weeks with a 16-hr transdermal patch of 15 mg, followed by a 6 + 6-weeks weaning period on respectively 10 and 5 mg patches. Gum use was not restricted during the first 6 months, with recommendations to use at least four pieces a day. A strict definition of smoking abstinence was used in this study, which did not allow smoking any cigarette after Week 1. Nonsmoking status at each visit, as reported by the subjects, was verified by CO below 10 ppm in expired air. RESULTS: Abstinence rates in group 1 against group 2 were 34.2 and 22.7% (P = 0.027) at 12 weeks, 27.5 and 15.3% (P = 0.010) at 24 weeks, and 18.1 and 12.7% (P = 0.191) at 52 weeks. In group 3, abstinence rates were 17.3, 14.7, and 13.3% respectively at 12, 24, and 52 weeks. Using logistic regression with adjustment for six baseline covariates, odds ratios for abstinence (with 95% CI) were computed. For group 1/group 2, OR at 12, 24, and 52 weeks were 1.72 (1.03-2.94) (P = 0.039), 2.04 (1.14-3.57) (P = 0.018), and 1.47 (0.76-2.76) (P = 0.125). No significant differences in OR were observed when comparing groups 2 and 3. Time to relapse is significantly longer in group 1 as compared to that of group 2 (P = 0.041), whereas no significant differences between groups 2 and 3 were observed. No significant differences between the three groups in systemic and local adverse drug events were observed. CONCLUSION: Adding active gum use to active patch use in subjects smoking 10 cigarettes or more a day increased abstinence rates, which are statistically significant up to 24 weeks.

Administration, Cutaneous↗
PubMed1995

Prevalences and correlates of ECG abnormalities in the adult Belgian population.

Data from 5,817 men and 5,215 women (age range, 25-74 years) who participated in the Belgian Interuniversity Research on Nutrition and Health were used to determine prevalences and associated variables of different abnormalities on the resting electrocardiogram. Electrocardiographic abnormalities were coded according to the Minnesota classification system. About one third of the subjects showed one or more abnormalities on their electrocardiogram. Major abnormalities occurred in 7.3% of the men and in 4.6% of the women. The prevalence of minor abnormalities was twice as high. Minnesota codes 4 (ST abnormalities) and 5 (T wave changes) were found to be the most prevalent in both sexes (9.6 and 10.5% respectively in women and 8.4 and 9.1% respectively in men), while code 2 (QRS axis deviation, 7.9%) and code 7 (ventricular conduction defect, 8.7%) were quite common in men. Most prevalences were rather log-linearly related with age, except codes 6 (atrioventricular conduction defect) and 9 (miscellaneous items). In the asymptomatic subjects, blood pressure showed the strongest positive correlation with minor ST-T abnormalities in both men and women independent of other factors. Other correlates identified by multivariate analyses were serum potassium, serum phosphor, and serum uric acid levels, as well as the intake of diuretics. However, any major, minor, and ST-T abnormalities were, according to sex, differently related to those correlates.

Adult↗