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PubMedDate not supplied

Personal computer program for processing data from patients with colo-rectal cancer.

A personal computer has been used to save labour and time in handling the data of patients with colo-rectal cancer. The program was written in N-88 BASIC to run on PC-8800 series equipment (PC-8801 processor, PC-8881 floppy disk unit, PC-8822 printer and PC-8853 CRT) manufactured by NEC Co., Ltd. This program enables data on patients to be easily input and instantly expressed. Data input is done by the cursor method, making input very quick and straightforward. Changes, additions and deletions to the data are very easy and output can be made to both display and printer. Data searching is done according to the enquiry and a print out can be obtained at any time for ready-to-read information. The Japanese nation-wide protocol for colo-rectal cancer is used as the basis for the system, providing almost complete linking with the national registry for any statistical data.

Colonic Neoplasms↗

PubMedDate not supplied

Semiquantitative evaluation of hepatic fibrosis by measuring tissue hydroxyproline.

BACKGROUND/AIMS: It is important to evaluate the degree of hepatic fibrosis when diagnosing and treating hepatic cirrhosis. We focused on hydroxyproline, which is detected specifically in collagen, which plays a major role in hepatic fibrosis. The correlations between liver tissue hydroxyproline residue levels and the degree of hepatic fibrosis were examined in dogs with dimethylnitrosamine-induced fibrotic livers. METHODOLOGY: Dimethylnitrosamine was administered to dogs to establish experimental hepatic fibrosis. Paraffinized sections of liver specimens, stained with hematoxylin-eosin and azan, were examined and the degree of hepatic fibrosis was graded. About three-milligram samples of liver tissue were loaded onto a fully automated liquid chromatograph and the levels of hydroxyproline residues were measured. RESULTS: The liver tissue hydroxyproline appeared to reflect the degree of hepatic fibrosis. The liver tissue hydroxyproline levels and pathological hepatic fibrosis grades correlated significantly (p<0.05). CONCLUSIONS: Tissue hydroxyproline appears to be a more useful fibrosis marker, because hydroxyproline is influenced less by other factors. Furthermore, our results demonstrate that a very small amount of liver tissue (wet weight 3 mg) was enough to enable the levels of hydroxyproline residues to be measured by an automated amino acid analyzer (JLC-3000) and hepatic fibrosis is expressed as the numerical value by this analysis.

Animals↗