Involvement of cytochrome P-450 in delta 22-desaturation in ergosterol biosynthesis of yeast.
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Biomedical subjects
Publications and source records attributed to M Komori.
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This paper describes the superiority of systolic pulsatile selective coronary perfusion as compared to diastolic pulsatile coronary perfusion in improving flow beyond ischemia-producing coronary artery obstructions in the working heart. The practical implications for use in coronary support perfusion systems are discussed.
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The effects of complete right bundle branch block (CRBBB) on the early postoperative course and long-term follow-up results of closure of ventricle septal defect (VSD) were investigated. (1) Postoperative change in cardiothoracic ratio (CTR); In patients whose ratio of total pulmonary resistance to total systemic resistance (Rp/Rs) was larger than or equal to 0.33, CTR of the group with CRBBB did not decrease significantly (p greater than 0.1) but CTR of the group without CRBBB was improved markedly (p less than 0.01). However, in patients whose Rp/Rs was less than 0.33, there was no significant difference in CTR reduction between the two groups. (2) Postoperative change in Rp/Rs in patients with preoperative Rp/Rs larger than or equal to 0.33: In the group with CRBBB the Rp/Rs decreased from a preoperative average of 36 to 27 percent; in the group without CRBBB, it decreased from 39 to 21 percent. There were significant differences in both the postoperative value of RP/Rs and the degree of postoperative decrease in Rp/Rs between the two groups (both p less than 0.05). (3) Change of pulse rate in the early postoperative period: In patients with Rp/Rs larger than or equal to 0.33, the postoperative increase in pulse rate of the group with CRBBB was significantly higher than that of the group without CRBBB (p less than 0.05). These results suggest that CRBBB has a strong deleterious effect on right ventricular function. The possibility that CRBBB has an ill effect on left ventricular function in patients with Rp/Rs larger than or equal to 0.33 is discussed.
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A pilot PACS project, named KIDS, has been running in Kyoto University Hospital. The purpose of the system is to establish a small PACS that includes all digital imaging modalities and to evaluate it. The project has been continued from the first phase (KIDS-1) to the second phase (KIDS-2). In the first phase, a small-scale PACS was developed. In the second phase, the expansion of coverage of modalities and completion of the image database was intended. At present, the database contains image data of 16264 patients amounting to 150 Gbytes. Simulation of the retrieval process to the database shows that 154.3 s per patient is required for retrieving his/her entire image data. This calculated value is close to the actual time.
A new eggshell color mutant was discovered in the Japanese quail. This trait was named "celadon" and was shown to be controlled by an autosomal recessive gene. Therefore, the gene symbol ce was proposed. This gene and an autosomal recessive gene we controlling a white eggshell trait were shown to be nonallelic. Also, ce was shown to be hypostatic to we. A spectrophotometric analysis revealed that the celadon eggshell pigments are protoporphyrin and biliverdin as in the wild-type eggshell, but the protoporphyrin content is much lower than that of the wild type. The biliverdin content was 44% of the wild type.
The effects of oxygen inhalation on peripheral hemodynamics were studied in vivo. We observed changes in the cutaneous microcirculation in the rabbit under various inspiratory oxygen concentrations. Blood vessel diameter, blood-flow velocity and blood-flow rate were gradually reduced as oxygen concentrations were increased from 30%. These results indicate that inspiration of more than 30% oxygen causes deterioration of the microcirculation.
This study aims to investigate the effects of ulinastatin, a human urinary trypsin inhibitor, on the cutaneous microcirculation during inhalation of 100% oxygen in the rabbit. Twenty-one rabbits having a rabbit ear chamber (REC), were divided into 2 groups: 11 rabbits without ulinastain treatment (Group C) and 10 rabbits with ulinastatin (Group U). After air inhalation, the inspired gas was changed to 100% oxygen. In Group U, 50,000 units of ulinastatin were administered before changing the concentration of inspired gas. The results suggests that ulinastatin may be useful for maintaining the cutaneous microcirculation during inhalation of 100% oxygen.