Liver changes in Down's syndrome.
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Autopsy↗
Biomedical subjects
M Koike
Publications and source records attributed to M Koike.
Application of reconstruction computed tomography in a case of tuber cinereum hamartoma.
A case of a 2-year-old girl with tuber cinereum hamartoma is evaluated by computed tomography (CT). Special reference is made to the application of CT image reconstruction, which has not yet been reported in the literature. The location, extent, shape and size of the mass lesion and also the anatomical relationship to adjacent structures are clearly demonstrated in sagittal and coronal CT images reconstructed from serial thin-section CT images in conjunction with target imaging and a review program.
Child, Preschool↗
The increase of CD5LOW+NK cells in patients with multiple myeloma and plasmacytoma.
CD5 antigen is present on all normal alpha beta T cells and some B cells. Human NK cells do not usually express CD5 antigen, but we found a novel subset of CD5LOW (low density of CD5) positive (CD5LOW+) natural killer cells (NK cells) in patients with multiple myeloma (MM) and plasmacytoma. To detect CD5LOW+NK cells, we examined the lymphocytes of 23 patients with MM and plasmacytoma by flow cytometry. Five out of 23 patients had CD5LOW+NK populations. These patients had many more NK cells than the other patients in the peripheral blood and bone marrow. The CD5LOW+NK cells had CD2, low density of CD8, CD16 and CD56, but no CD3, CD19, or CD20. Most of the CD5LOW+NK cells had HLA-DR, unlike the CD5-NK cells. Sorted CD5LOW+CD16+ populations were large granular lymphocytes (LGL). The CD5LOW+NK cells had some lytic activity on K562 cells in a 4-hour 51Cr release assay. Our results indicate that there is a novel subset of NK cells in some patients with MM and plasmacytoma and that CD5LOW+NK cells may be associated with NK cell activation.
Adult↗
A case of hepatocellular carcinoma in HIV-infected patient.
Persistent human immunodeficiency virus (HIV) infection induces an immuno-suppressive state and therefore malignant tumors are a very common complication. Hepatocellular carcinoma is very rare, however, because it is associated with chronic liver disease by the persistent infection of hepatitis B or C virus (HBV or HCV). We reported a case of HCC with HIV infection who had no evidence of HBV or HCV infection, and that had a rapid growth and active pulmonary metastases. Pathological findings of the resected liver showed moderately differentiated HCC and no chronic liver disease. Despite efforts to find potential HBV integration in tumor and non-tumor tissue, none was observed. To our knowledge, this is the first report of HCC in HIV-infected patient with no evidence of hepatitis virus infection.
Carcinoma, Hepatocellular↗
A case of hepatocellular carcinoma in normal liver with no evidence of HBV or HCV infection.
We reported a very rare case of hepatocellular carcinoma (HCC) developed in a normal liver without persistent hepatitis B or C virus (HBV or HCV) infection. A 39-year-old woman was admitted to our hospital for epigastralgia. Laboratory data demonstrated normal liver function and she had no evidence of past and persistent HBV or HCV infection. Abdominal ultrasonography and abdominal CT scan demonstrated liver tumor of about 40 mm in maximal diameter in the lateral segment. This tumor was moderately differentiated hepatocellular carcinoma (HCC) from the result of operative sample, and the non-tumor area surrounding the HCC was normal pathological finding. The potential integration of HBV DNA into tumor or non tumor cells was not observed. This is a very rare case of hepatocellular carcinoma developed in a normal liver without HBV and HCV infection.
Adult↗
A splenic-inferior mesenteric venous anastomosis prevents gastric congestion following pylorus preserving pancreatoduodenectomy with extensive portal vein resection for cancer of the head of the pancreas.
BACKGROUND: In order to prevent gastric congestion after both of the splenic and coronary veins were taken as part of extensive portal vein resection in pylorus preserving (PP) pancreatoduodenectomy (PD), we made a splenic-inferior mesenteric venous (SpIMV) anastomosis. MATERIALS AND METHODS: Four patients underwent PP subtotal PD with such extensive portal vein resection under the diagnosis of pancreas head cancer. The portal vein was reconstructed by end-to-end anastomosis, and the coronary vein was ligated. Since the stump of the splenic vein could not be approximated to the portal or superior mesenteric vein, shunting the splenic venous flow to the inferior mesenteric vein was attempted by making a SpIMV anastomosis in 3 patients and by preserving the SpIMV confluence in a patient. Postoperative celiac angiography showed that venous outflow from the stomach, spleen and remnant pancreas collected into the splenic vein and passed through the SpIMV anastomosis or confluence, and finally drained into the portal vein by inferior mesenteric to superior mesenteric collateral. RESULTS: No remarkable congestion of the stomach was observed. CONCLUSIONS: In conclusion making a SpIMV anastomosis or preserving the SKpIMV confluence is beneficial for preventing gastric congestion following PP PD with extensive portal vein resection for cancer of the head of the pancreas.
Aged↗
Minute mixed hepatoma with two components: hepatocellular and cholangiocarcinoma, which developed on liver cirrhosis with HCV.
Mixed type hepatoma with two components, hepatocellular and cholangiocellular carcinoma, is very rare. We encountered a case of a single and minute mixed type hepatoma developing on liver cirrhosis in a patient with persistent hepatitis C viral infection. Histologically, the two-type cancer tissue existed in a nodule with a maximal diameter of approximately 20 mm, and the cholangiocellular carcinoma occupied about 70% of the tumor. The original cell of the mixed type hepatoma is unknown, but this case suggests that a bipotential cell developing into hepatocellular and cholangiocellular carcinoma may be the origin.
Carcinoma, Hepatocellular↗