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Biomedical subjects

M Knoop

Publications and source records attributed to M Knoop.

At least 91 records · Page 5Linked to original sources
PubMed1991

[Technique of microvascular jejunum transfer for replacement of the cervical esophagus].

Technique and results of the first 10 free jejunal grafts after pharyngolaryngectomy are presented. End-to-side venous anastomosis and end-to-side pharyngojejunostomy instead of end-to-end techniques are proposed. Hospital mortality was 0 and as minor complications 1 uncomplicated fistula of the proximal and 1 stenosis of the distal anastomosis along with 1 wound infection were seen. There were no vascular complications and no graft loss. All patients were able to swallow and to eat thus an excellent quality of life was achieved.

Adult↗
PubMed1990

Staining of native and grafted exocrine rat pancreas by an interleukin-2 receptor specific monoclonal antibody.

Immunohistological studies of native and grafted rat pancreas tissue with mouse anti-rat monoclonal antibodies revealed an unexpected staining pattern of MRC Ox 39 which binds specifically to rat interleukin-2 (IL-2) receptors. While the cytoplasm of acinar cells of native pancreas was stained, the lumina of the acini remained uncoloured. In grafted exocrine tissue, the staining pattern was quite reverse. Only the apical cytoplasm of acinar cells was stained while the acinar lumina exhibited an intense stain. Common binding sites shared between the IL-2 receptor and a hypothetical exportable protein in acinar cytoplasm could explain these observations.

Animals↗
PubMed1989

Acute pancreatitis after experimental pancreatic transplantation.

We describe our serendipitous finding of a transplantation model of hemorrhagic pancreatic necrosis. The slow evolution, from edematous interstitial pancreatitis to hemorrhagic necrosis over the course of 8 days made the model amenable to therapeutic manipulation. The possible pathogenesis is discussed with reference to the published literature. From comparisons between the histologic and biochemical features of isografts and allografts, we suggest that ischemia-reperfusion injury initiates pancreatitis through oxygen-free radicals, and that the transformation to hemorrhagic pancreatic necrosis in allografts reflects the involvement of chemotactic immune factors and extracellular secretions from activated proteases.

Acute Disease↗
PubMed1987

[Maxon and PDS--evaluation and physical and biologic properties of monofilament absorbable suture materials].

The physical parameters of monofilament absorbable sutures (Maxon and PDS) were studied. Compared to PDS Maxon proved somewhat more unwieldy, however, it required less complicated knot combinations for a secure placement than PDS did. In vivo experiments on rats showed a slight tissue reaction and a dissolution time of 120-180 days for Maxon and 180-240 days for PDS. With Maxon, tensile strength was measurable for 42-49 days, while the period for PDS amounted to 65-80 days. New indications for these materials are discussed, two parameters, easy knot formation and atraumatic passage through the tissue, especially favor the use of Maxon for one-row all-layer sutures in the gastrointestinal tract.

Animals↗
PubMed1986

[Review of the physical and surgical technical properties of modern monofilament suture materials].

This paper documents the differences among 8 monofile sutures in important functions such as linear tensile strength, bending stiffness, knot security and irreversible elongation. The results show that two materials (Prolene and Gore-Tex) do not seem to be as suitable as the other materials for long-term tensile loads. The lowest bending stiffness was that of Seralon. The highest knot security can already be reached with three loops of Novafil. Novafil has also got the highest maximal elongation. The knowledge of the different applications of suture materials tested in important practical functions, is the supposition to the right and secure use of suture materials.

Elasticity↗