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Biomedical subjects

M Klima

Publications and source records attributed to M Klima.

At least 37 records · Page 2Linked to original sources
PubMed1987

Malignant granular cell tumor.

A case of a granular cell tumor with a malignant behavior is described. Several repeated biopsy specimens, a resection specimen, and the metastatic lesions were compared with one another. Consecutive specimens showed increasing atypia. Electron microscopy of the metastatic lesions confirmed the granular cell nature of the tumor. The historic aspects of histogenesis are briefly discussed. The findings agree with a presently accepted origin from a primitive mesenchymal cell.

Humans↗
PubMed1986

Culture-negative endocarditis with purpura and arterial emboli.

We have presented a case of culture-negative endocarditis in which purpura and arterial emboli were the major findings, and in which echocardiograms were normal, but angiograms revealed vegetations and unsuspected severe aortic valve insufficiency.

Aortic Valve Insufficiency↗
PubMed1986

[Morphogenesis of the highly specialized nasal skull in the sperm whale (Physeter macrocephalus). I].

Investigated the morphogenesis of the nasal structures of the chondrocranium and determatocranium in 15 embryos and foetuses of the sperm whale (Physeter macrocephalus). In the very early stages of the morphogenesis, the nasal capsule of Physeter shows a conspicuous similarity with that of all other odontocetes. In the following stages there are some important differences. Most peculiar is the occurrence of the cartilaginous tectum nasi with the cupulae nasi anteriores, elements which are reduced in all other odontocetes. This cartilaginous complex as a slender band projects obliquely forward from the upper edge of the anterior septal margin. It is free, i.e. not accompanied by membraneous bones. The complex represents the most important factor in the morphogenesis and growth of the characteristic big forehead in Physeter, which contains the spermaceti organ unique within the odontocetes. Other important differences concern the changes in the orientation of the nasal passages and the adjacent skeletal structures. Nevertheless, these differences have to be taken as specializations related to the development of the far-advanced spermaceti organ. As a whole, the embryonic nasal structures in Physeter belong to the same general type of nasal capsule which is common to all odontocetes. The results presented here suggest a close phylogenetic relationship between Physeter and the other Odontoceti.

Animals↗
PubMed1985

Pacemaker associated infection due to a corynebacterium species.

Pacemaker associated infection (PAI) is a rare but often serious complication of permanent or temporary transvenous cardiac pacemakers. The major risk factor is recent or multiple pacemaker manipulations or surgical procedures. A PAI can occur at the time of insertion, from contiguous spread to the access site, or from transient bacteremia. We report a case of PAI of a retained pacemaker electrode from which a Corynebacterium species was isolated. Multiple preoperative cultures were sterile, but bacteria were isolated from tissue removed at surgery, and were seen around the wire deep inside a thrombus. The importance of cultures and special stains (including electron microscopy) of surgical materials is stressed, especially when dealing with microorganisms of ordinarily low virulence, or those that are commonly considered laboratory contaminants.

Journal Article↗
PubMed1985

[Additional skeletal elements in the nasal skull structure of Phocoena phocoena and the development of the nasal region in toothed whales].

Small nasal ossicles, occasionally occurring on the caudal border of the premaxillary bones in Phocoena and some other toothed whales (Odontoceti) up to now, were considered the remnants of maxilloturbinalia. The latter, however, originate from the cartilaginous lateral wall of the embryonal nasal capsule, whereas the ossicles mentioned are remnants of the nasal floor cartilages. These additional nasal structures are homologous with the lamina transversalis anterior, and also contain the material of the cartilago paraseptalis. In comparison with the quadrupedal terrestrial mammals, the skull of odontocetes shows some important differences in development. In the nasal region, the nasal tract is shifted backward from the top of the snout to the vertex of the head, while the bony rostrum projects far forward. These changes can already be observed during the early morphogenesis of skull. We have examined embryos of Phocoena, Lagenorhynchus, and Monodon, 16 different developmental stages altogether, representing the most complete material ever examined for this purpose. There is a marked developmental trend from a complicated nasal capsule, consisting of many isolated cartilages, to a simple reduced structure, being composed of some fused cartilages only. Whereas Monodon, Lagenorhynchus, and Globicephala still possess some of the original ancestral features, common to all mammals, Phocoena in this respect is the most advanced odontocete which has been investigated so far. In Phocoena, the tectum nasi and the lateral wall of the nasal capsule are widely reconstructed in embryonal life, turned upright and displaced caudally; thus it lies immediately in front of neurocranium. The floor of the original nasal capsule persists in 2 elements only, the lamina transversalis anterior and the paraseptal cartilage, both largely fusing with each other and losing their connection with the lateral nasal wall. During early morphogenesis they move to the top of the head, expanding along the upper border of the nasal septum. Together with the rostral part of the nasal septum, they join in the prolongation of the dolphin head and hold the space for the exoskeletal dermal bones which develop later. There is a direct connection between the lamina transversalis anterior and the premaxillary bone, as well as between the cartilago paraseptalis and the vomer. These topographical relationships persist until the adult stage of odontocetes.

Animals↗
PubMed1984

Hairy cell leukemia associated with focal vascular damage.

In a patient with hairy cell leukemia, segmental vascular alterations developed in many of the larger visceral arteries. In previously reported instances of this association, the vasculitis resembled polyarteritis nodosa. In contrast, in the present case the vessels did not show the typical necroses, polymorphonuclear infiltrates, and aneurysmal changes. Instead, vascular alterations consisted of edema, fibrosis, and infiltration by tumor cells. A possible pathogenetic mechanism for these findings may be a local immunologic interaction of tumor cells and vessels, suggesting a direct relation between hairy cell leukemia and vascular damage.

Coronary Vessels↗
PubMed1983

Sarcomatous type of malignant mesothelioma.

Thirteen malignant mesotheliomas of a sarcomatous type were studied by light microscopy and ten were studied by electron microscopy. The histologic patterns varied from tumor to tumor, often resembling other soft tissue sarcomas. Electron microscopic observation showed most of the tumors to be composed of primitive cells. Despite their mesenchymal character, many tumors contained foci of rudimentary epithelial differentiation. It is concluded that both histologic types of malignant mesothelioma, the epithelial as well as the sarcomatous, originate from the same precursor cell at various points of its differentiation and reflect the range of maturation from the mesenchymal reserve cell to the epithelial mesothelial cell.

Adult↗
PubMed1983

Osteomyelitis beneath pressure sores.

Twenty-eight pressure sores were evaluated prospectively. Osteomyelitis was reported histologically in nine of 28 bones and pressure-related changes were reported in 14 bones. Roentgenograms suggested the presence of osteomyelitis in four instances of histologically proved osteomyelitis. Technetium Tc 99m medronate bone scans were highly sensitive, showing increased uptake in all cases of osteomyelitis; however, increased uptake also occurred commonly in uninfected bones due to pressure-related changes or other noninfectious causes. Cultures of bone biopsy samples usually disclosed anaerobic bacteria, gram-negative bacilli, or both. The diagnosis of osteomyelitis must be considered if a pressure sore does not respond to local therapy. If the technetium Tc 99m medronate uptake is increased in the involved area, or roentgenographic findings are abnormal, the diagnosis can only be made with certainty by histologic examination of bone. Antibacterial treatment should be selected based on the results of bone culture.

Adult↗
PubMed1982

Sweat gland tumors of the head and neck.

Surgeons performing soft-tissue surgery in the head and neck area occasionally will encounter other varieties of neoplasms, such as skin-appendage tumors, in addition to basal cell carcinoma and squamous cell carcinoma. Sweat gland tumors are the most common variety of the skin-appendage tumors and the most easily confused with basal cell carcinoma and squamous cell carcinoma. We report this case to illustrate this fact. The classification of sweat gland tumors and their suggested management are reviewed.

Adenoma, Sweat Gland↗
PubMed1982

Transepithelial elimination in cutaneous sarcoidosis.

A patient known to have sarcoidosis exhibited cutaneous lesions. Microscopic examination of serial sections showed histologic evidence of transepithelial elimination of the sarcoidal granuloma. The concept and possible mechanisms of transepithelial elimination are discussed.

Adult↗
PubMed1980

Verrucous carcinoma of skin.

Five different cases of verrucous proliferative lesions of skin are described and discussed. One of each developed in a chronic ulcer on a heel, in a scar on a lower leg, and on the penis, and two appeared in the region of the buttock in relation to chronic inflammatory sinuses. All these lesions showed morphological and clinical features of verrucous carcinoma which are described. It has been concluded that the variously named verrucous lesions in the literature (epithelioma cuniculatum, florid papillomatosis, giant cutaneous papilloma and papillomatosis cutis carcinoides), as well as our five cases represent a verrucous carcinoma which is a particular type of squamous cell carcinoma. This tumor develops typically in moist areas which are frequently sites of chronic inflammation. Despite the favorable prognosis, it is a potentially invasive tumor.

Bacterial Infections↗
PubMed1978

Basal cell tumors of the parotid gland.

We present two patients with parotid tumors; one had a basal cell adenoma, and the other had a malignant tumor of uncommon morphologic features that was diagnosed as basal cell carcinoma. Both tumors showed morphologic similarities: peripheral, palisading, nests-like arrangements and organelle-poor cytoplasm. This suggests the same cell of origin.

Adenoma↗