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Biomedical subjects

M Klett

Publications and source records attributed to M Klett.

25 records · Page 2Linked to original sources
PubMed1978

[Adrenal function after long term treatment with beclomethasone dipropionate in childhood asthma (author's transl)].

Evaluating plasma levels of cortisol and corticosterone after ACTH-stimulation, and the urinary metabolites tetrahydrocortisone and tetrahydrocortisol in asthmatic children it could be demonstrated, that in most cases there was no suppression of adrenal function following treatment over 6 to 18 months with a daily dose of 200 to 300 microgram beclomethasone dipropionate. Since in a few patients suppression was found, an ACTH stimulation after a six months treatment is recommended.

Adolescent↗
PubMed1978

[Neonatal screening for hypothyroidism. Preliminary results from different methods (author's transl)].

In a regional study 2062 newborns were screened for congenital hypothyroidism by determination of TSH in plasma or dried blood spots on the fifth day of life. Three newborns with congenital hypothyroidism were detected. All of them showed high TSH-levels between 462 and 2192 micromicron/ml. One newborn with a congenital goiter had a TSH-level of 143 micromicron/ml. Additionally, in a follow-up study of 50 newborns with jaundice TSH, T4, T3 and reverse T3 during the first 120 h of life were measured. Efficiency of the different methods concerning their applicability to mass screening is discussed.

Congenital Hypothyroidism↗
PubMedDate not supplied

PCB-blood levels in teachers, working in PCB-contaminated schools.

In order to get more information about potential health hazards due to indoor air PCBs the present study investigated the PCB indoor concentration in schools as well as the blood levels of 6 PCB-indicator congeners in teachers from these schools. 151 teachers (78 male and 73 female; mean age 48 years) from 3 contaminated and 2 control schools participated in the study. Maximal indoor air values for total PCBs (6 PCB-indicator congeners times 5) in schools ranged from 1587 to 10655 ng/m3. Blood analyses indicated an increase in mean PCB 28 level from 0.036 (control group) to 0.098 microg/l in teachers from a school with heavy contamination of low chlorinated PCB. But there was no significant increase of PCB 138, 153 and 180 in blood above the normal background concentrations in any of the contaminated schools (mean values of all groups: PCB 138 = 0.66, 153 = 0.95, 180 = 0.70 microg/l blood). The results of blood analyses and additional toxicokinetic calculations suggested that inhalative PCB-uptake in the most contaminated schools caused a minor increase above mean background-PCB concentrations in blood. In conclusion, despite high PCB indoor air levels in schools, there was only a moderate increase in blood concentrations of teachers, mainly due to congeners with low chlorination (PCB 28 to PCB 101).

Adult↗
PubMedDate not supplied

[Evaluation of the toxicity of particle-bound dioxins and furans in the environment of a metal plant].

During the last years increased PCDD/PCDF-levels were found in soil, dust and vegetables in a living area close to a metal reclamation plant in Southern Germany. 450 volunteers participated in a clinical and laboratory trial. In a randomised group of 22 persons PCDD/PCDF concentrations have been investigated from blood samples. The range of PCDD/PCDF between 16-80 (mean 31) did not vary substantially from values in non-exposed national samples. Results of clinical history and clinical and laboratory testing did not correlate with emission, time of exposure or PCDD/PCDF concentrations of blood samples. It is suggested that PCDD/PCDF of pyrolytic origin may be incorporated to a lesser extent in humans.

Adolescent↗