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Biomedical subjects

M Kitamura

Publications and source records attributed to M Kitamura.

At least 613 records · Page 34Linked to original sources
PubMed1980

Assessment of brainstem damage by the auditory brainstem response in acute severe head injury.

In 64 cases suffering from severe head injury (Glasgow coma scale: less than seven- the auditory brainstem responses (FARs) recorded at the vertex, which are thought to be volumet conducted far-field potentials reflecting the sequential electrical activities of the auditory afferen) system in the brainstem, were recorded in the neurosurgical intensive care room immediately after admission. The alterations in the responses were compared with the types of primary injury, neurological signs., CT findings and outcome following treatment. Based on the results obtained, it is concluded that the FAR is a useful indicator for predicting the effects of treatment on brainstem damage in patients with severe head injury, and that it provides more reliable information about the function of the brainstem than the neurological signs or CT findings. Moreover, it also offers a diagnostic method for primary brainstem injury. Three cases or primary brainstem injury without lesions in the supratentorial region were diagnosed by means of combined CT and FAR recording.

Adult↗
PubMed1980

[Diagnostic value of the far field acoustic response (FAR) as an objective evaluating method for brainstem injury (author's transl)].

Far Field Acoustic Response (FAR) was repeatedly studied from acute stage to chronic stage of severe head injury in 64 patients for evaluation of the degree of brainstem injury. (1) In acute stage within 7 days after trauma, FAR abnormalities are found in 56% of the subjects with severe head injury. These abnormalities are as follows: (i) Prolongation of latency, disappearance of the 5th wave. (ii) Disappearance of the 1st-5th waves or 2nd-5th waves. The incidence of FAR abnormalities is not correlated to disease categories and age of the subjects. (2) FAR findings reveal more precisely the level of brainstem dysfunction than by clinical assessments of brainstem reflexes and posture, and by computerized tomography. (3) Evaluating results of the FAR recorded within 7 days after trauma are correlated to the outcome 3 or more months after injury in the subjects. Almost of them with alteration of only the 5th wave in FAR improve clinically and electrophysiologicaly at 2-3 weeks after trauma. However any patients with disappearance of the 1st-5th waves in FAR are fatal or fell into the state of vegetation. According to these results, it was concluded that FAR has a important diagnostic value as an objective evaluating method for brainstem dysfunction in patients with severe closed head injury.

Adolescent↗
PubMed1979

[Amylase].

Explore the source record for details and available documents.

Amylases↗
PubMed1979

Application of magnification radiography to the biliary system.

Magnification radiography was applied for the diagnosis of the biliary tract diseases including cancer. Our X-ray unit was consisting of HITACHI DR-155-23 U-6M-55P and 0.1 mm focal-spot tube, FFD 80 cm giving a magnification of x2 with the conditions of 60 kVp, 20 mA, 0.8 sec. Intensifying screens such as Kyokko LH II (for a standard sized subject) or DuPont Q II (for an obese subject) were used in combination with Fuji RX films. We confirmed a high diagnostic value in revealing early lesions of this sytem. The skin dose test indicated that this technique was routinely applicable with safety for clinical use.

Biliary Tract↗
PubMed1979

Binding of Clostridium botulinum neurotoxin to the presynaptic membrane in the central nervous system.

Large synaptosome fractions were isolated from the cerebellar and cerebral cortices of rats and were incubated with Clostridium botulinum type A neurotoxin in vitro. The binding of the neurotoxin to the synapses was observed by electron microscopy, using the double-sandwich immunocytochemical method. Botulinum neurotoxin was preferentially bound to the presynaptic membrane in the large synaptosome fraction. The binding regions for the neurotoxin were localized on both the extrajunctional and junctional areas of the presynaptic membranes and appeared as patches of various sizes. However, they did not exist on the postsynaptic membranes. Botulinum neurotoxin is proposed to be a useful analytical tool for understanding the characteristics of the presynaptic membranes in the central nervous system.

Animals↗
PubMed1979

Sex hormone binding globulin as a reliable indicator of hormone dependence in human breast cancer.

One hundred nine pre- and postmenopausal mammary carcinoma cases were studied to elucidate the role of sex hormone binding globulin (SHBG) in the hormone dependence of human breast cancer. Our findings indicate that there is a significant negative correlation between SHBG binding capacity and plasma testosterone concentration. All patients with high SHBG titers were found to be cytosol estrogen receptor (CER) positive and the plasma SHBG binding capacity of CER positive was significantly higher than that of CER negative patients. We also found that the level of pretherapy plasma SHBG concentration is a reliable indicator in predicting the efficacy of hormone therapy. Our findings also confirm that, for a tumor to be hormone dependent, high plasma SHBG concentration and estrogen receptors must be present simultaneously. The present pretherapy determination of SHBG titers is easier and more reliable than previous methods for determining the hormone dependence of human breast tumors.

Adult↗